Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3649-3655

  Zhang, Han Zhong ^a   Drewe, John ^a   Tseng, Ben ^a   Kasibhatla, Shailaja ^a   Cai, Sui Xiong ^a  

^a Maxim Pharmaceuticals Inc   (United States)

Author keywords

Anticancer drugs; Apoptosis inducers

Indexed keywords

5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(2 METHYLBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(3 METHYLBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(3 NITROBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(4 CHLOROBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(4 DIMETHYLAMINOBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(4 METHYLBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 METHYLINDOLE 2 CARBOXYLIC ACID(4 NITROBENZYLIDENE)HYDRAZIDE; 5 CHLORO 3 PHENYLINDOLE 2 CARBOXYLIC ACID(4 NITROBENZYLIDENE)HYDRAZIDE; 5 CHLOROINDOLE 2 CARBOXYLIC ACID(4 NITROBENZYLIDENE)HYDRAZIDE; 5 METHYL 3 PHENYLINDOLE 2 CARBOXYLIC ACID(4 METHYLBENZYLIDENE)HYDRAZIDE; ANTINEOPLASTIC AGENT; BENZENE; BENZYLIDENE DERIVATIVE; CASPASE; INDOLE; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PROTEIN POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; HYDRAZINES; INDOLES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

STAPHYLOCOCCUS PHAGE 3A;

EID: 2942573512     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.017     Document Type: Article

References (17)

1. Thompson C.B. Science. 267:1995;1456-1462
2. Reed J.C., Tomaselli K.J. Curr. Opin. Biotechnol. 11:2000;586-592
3. Tolomeo M., Simoni D. Curr. Med. Chem. AntiCancer Agents. 2:2002;387-401
4. Hayakawa Y., Kim J.W., Adachi H., Shin-ya K., Fujita K.-I., Seto H. J. Am. Chem. Soc. 120:1998;3524-3525
5. Wang H., Yeo S.L., Xu J., Xu X., He H., Ronca F., Ting A.E., Wang Y., Yu V.C., Sim M.M. J. Nat. Prod. 65:2002;721-724
6. Jakobsen C.M., Denmeade S.R., Isaacs J.T., Gady A., Olsen C.E., Christensen S.B. J. Med. Chem. 44:2001;4696-4703
7. Simoni D., Roberti M., Invidiata F.P., Rondanin R., Baruchello R., Malagutti C., Mazzali A., Rossi M., Grimaudo S., Capone F., Dusonchet L., Meli M., Raimondi M.V., Landino M., D'Alessandro N., Tolomeo M., Arindam D., Lu S., Benbrook D.M. J. Med. Chem. 44:2001;2308-2318
8. Thornberry N.A. Chem. Biol. 5:1998;R97-R103
9. Cai S.X., Zhang H.Z., Guastella J., Drewe J., Yang W., Weber E. Bioorg. Med. Chem. Lett. 11:2001;39-42
10. (b) Cai, S. X.; Keana, J. F. W.; Drewe, J. A.; Zhang, H. Z. U.S. Patent 6,335,429, column 116, example 25, column 117, example 30 and 31, 2002
11. Cai S.X., Nguyen B., Jia S., Guastella J., Reddy S., Tseng B., Drewe J., Kasibhatla S. J. Med. Chem. 46:2003;2474-2481
12. Zhang H.Z., Kasibhatla S., Wang Y., Herich J., Guastella J., Tseng B., Drewe J., Cai S.X. Bioorg. Med. Chem. 12:2004;309-317
13. Liu R., Zhang P., Gan T., Cook J. J. Org. Chem. 62:1997;7447-7456
14. Morton S. J. Biol. Chem. 179:1949;259-264
15. Green D.R., Reed J.C. Science. 281:1998;1309-1312
16. Jordan M.A. Curr. Med. Chem. Anticancer Agents. 2:2002;1-17
17. Barron D.M., Chatterjee S.K., Ravindra R., Roof R., Baloglu E., Kingston D.G.I. Anal. Biochem. 315:2003;49-56