Enzymatic Mechanism of Low-Activity Mouse Alcohol Dehydrogenase 2

Biochemistry

Volumn 43, Issue 5, 2004, Pages 1323-1328

  Strömberg, Patrik ^a,c   Svensson, Stefan ^a,d   Berst, Kristine B ^b   Plapp, Bryce V ^b   Höög, Jan Olov ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF IOWA   (United States)

^c ASTRAZENECA R AND D   (Sweden)

^d BIOVITRUM AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOCHEMISTRY; CATALYST ACTIVITY; HYDRIDES; IONIZATION; OXIDATION; PH EFFECTS;

DEPROTONATION; LIGANDS;

ENZYMES;

ALANINE; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 2; ALCOHOL DERIVATIVE; BENZYL ALCOHOL DERIVATIVE; GLUTAMINE; HISTIDINE; LIGAND; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROLINE; UNCLASSIFIED DRUG; WATER; ZINC;

ALCOHOL OXIDATION; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; IONIZATION; MOUSE; NONHUMAN; PARAMETER; PH; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; STEADY STATE; STRUCTURE ANALYSIS; WILD TYPE;

ALANINE; ALCOHOL DEHYDROGENASE; AMINO ACID SUBSTITUTION; ANIMALS; BENZYL ALCOHOL; CATALYSIS; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME ACTIVATION; GLUTAMINE; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; PROLINE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

MAMMALIA; RODENTIA;

EID: 0842347937     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0354482     Document Type: Article

References (37)

1. Edenberg, H. J., and Bosron, W. F. (1997) in Comprehensive Toxicology (Guengerich, F. P., Ed.) pp 119-131, Pergamon Press, New York.
2. Höög, J.-O., Hedberg, J. J., Strömberg, P., and Svensson, S. (2001) J. Biomed. Sci. 8, 71-76.
3. Duester, G., Farrés, J., Felder, M. R., Holmes, R. S., Höög, J.-O., Parés, X., Plapp, B. V., Yin, S. J., and Jörnvall, H. (1999) Biochem. Pharmacol. 58, 389-395.
4. Theorell, H., and Chance, B. (1951) Acta Chem. Scand. 5, 1127-1144.
5. Wratten, C. C., and Cleland, W. W. (1963) Biochemistry 2, 935-941.
6. Brändén, C.-I., Jörnvall, H., Eklund, H., and Furugren, B. (1975) in The Enzymes (Boyer, P. D., Ed.) pp 103-190, Academic Press, New York.
7. Bosron, W. F., Li, T.-K., Lange, L. G., Dafeldecker, W. P., and Vallee, B. L. (1977) Biochem. Biophys. Res. Commun. 74, 85-91.
8. Li, T.-K., Bosron, W. F., Dafeldecker, W. P., Lange, L. G., and Vallee, B. L. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 4378-4381.
9. Estonius, M., Svensson, S., and Höög, J.-O. (1996) FEBS Lett. 397, 338-342.
10. Mårdh, G., Dingley, A. L., Auld, D. S., and Vallee, B. L. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8908-8912.
11. Consalvi, V., Mårdh, G., and Vallee, B. L. (1986) Biochem. Biophys. Res. Commun. 139, 1009-1016.
12. Sellin, S., Holmquist, B., Mannervik, B., and Vallee, B. L. (1991) Biochemistry 30, 2514-2518.
13. Ditlow, C. C., Holmquist, B., Morelock, M. M., and Vallee, B. L. (1984) Biochemistry 23, 6363-6368.
14. Höög, J.-O. (1995) FEBS Lett. 368, 445-448.
15. Svensson, S., Strömberg, P., and Höög, J.-O. (1999) J. Biol. Chem. 274, 29712-29719.
16. Eklund, H., Nordström, B., Zeppezauer, E., Söderlund, G., Ohlsson, I., Boiwe, T., Söderberg, B. O., Tapia, O., Brändén, C.-I., and Åkeson, Å. (1976) J. Mol. Biol. 102, 27-59.
17. Gould, R. M., and Plapp, B. V. (1990) Biochemistry 29, 5463-5468.
18. Hurley, T. D., Edenberg, H. J., and Bosron, W. F. (1990) J. Biol. Chem. 265, 16366-16372.
19. Stone, C. L., Bosron, W. F., and Dunn, M. F. (1993) J. Biol. Chem. 268, 892-899.
20. Light, D. R., Dennis, M. S., Forsythe, I. J., Liu, C.-C., Green, D. W., Kratzer, D. A., and Plapp, B. V. (1992) J. Biol. Chem. 267, 12592-12599.
21. Svensson, S., Höög, J.-O., Schneider, G., and Sandalova, T. (2000) J. Mol. Biol. 302, 441-453.
22. Deng, W. P., and Nickoloff, J. A. (1992) Anal. Biochem. 200, 81-88.
23. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
24. Frieden, C. (1994) Methods Enzymol. 240, 311-322.
25. Bosron, W. F., Li, T. K., Dafeldecker, W. P., and Vallee, B. L. (1979) Biochemistry 18, 1101-1105.
26. Sekhar, V. C., and Plapp, B. V. (1990) Biochemistry 29, 4289-4295.
27. Jörnvall, H., Hempel, J., Vallee, B. L., Bosron, W. F., and Li, T.-K. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 3024-3028.
28. Kvassman, J., and Pettersson, G. (1978) Eur. J. Biochem. 87, 417-427.
29. Kvassman, J., and Pettersson, G. (1980) Eur. J. Biochem. 103, 557-564.
30. Kvassman, J., Larsson, A., and Pettersson, G. (1981) Eur. J. Biochem. 114, 555-563.
31. Eklund, H., Plapp, B. V., Samama, J.-P., and Brändén, C.-I. (1982) J. Biol. Chem. 257, 14349-14358.
32. Ehrig, T., Hurley, T. D., Edenberg, H. J., and Bosron, W. F. (1991) Biochemistry 30, 1062-1068.
33. Davis, G. J., Carr, L. G., Hurley, T. D., Li, T.-K., and Bosron, W. F. (1994) Arch. Biochem. Biophys. 311, 307-312.
34. Ramaswamy, S., el Ahmad, M., Danielsson, O., Jörnvall, H., and Eklund, H. (1996) Protein Sci. 5, 663-671.
35. Yang, Z. N., Bosron, W. F., and Hurley, T. D. (1997) J. Mol. Biol. 265, 330-343.
36. Ramaswamy, S., Park, D.-H., and Plapp, B. V. (1999) Biochemistry 38, 13951-13959.
37. Jones, T. A., Zou, J., Cowan, S., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.