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Volumn 23, Issue 1, 2000, Pages 179-201

Genetic polymorphisms in ethanol metabolism: Issues and goals for physiologically based pharmacokinetic modeling

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE;

EID: 0034009163     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-100100110     Document Type: Conference Paper
Times cited : (35)

References (35)
  • 2
    • 0019418683 scopus 로고
    • Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons
    • Sato, A., Nakajima, T. and Koyama, Y., Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons, Tox. Appl. Pharm., 60:8-15, 1981.
    • (1981) Tox. Appl. Pharm. , vol.60 , pp. 8-15
    • Sato, A.1    Nakajima, T.2    Koyama, Y.3
  • 3
    • 0016861504 scopus 로고
    • Cirrhosis in the alcoholic and its relation to volume of alcohol abuse
    • Lelbach, W.K., Cirrhosis in the alcoholic and its relation to volume of alcohol abuse, N.Y. Acad. Sci., 252:85-105, 1975.
    • (1975) N.Y. Acad. Sci. , vol.252 , pp. 85-105
    • Lelbach, W.K.1
  • 4
    • 0029084684 scopus 로고
    • An update on the incidence of FAS: FAS is not an equal opportunity birth defect
    • Abel, E.L., An update on the incidence of FAS: FAS is not an equal opportunity birth defect, Neurotox. Teratol., 17(4):437-443, 1995.
    • (1995) Neurotox. Teratol. , vol.17 , Issue.4 , pp. 437-443
    • Abel, E.L.1
  • 5
    • 0028589974 scopus 로고
    • Alcohol dehydrogenase from human stomach: Variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region
    • Morena, A., Pares, A., Ortiz, J., Enriquez, J. and Pares, X., Alcohol dehydrogenase from human stomach: Variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region, Alcoho. Alcoholism, 29(6):663-671, 1995.
    • (1995) Alcoho. Alcoholism , vol.29 , Issue.6 , pp. 663-671
    • Morena, A.1    Pares, A.2    Ortiz, J.3    Enriquez, J.4    Pares, X.5
  • 6
    • 0025105234 scopus 로고
    • High blood alcohol levels in women: Role of decreased gastric alcohol dehydrogenase activity and first pass metabolism of ethanol
    • Frezza, A., DiPadova, C., Pozzato, G., Terpin, M., Baraona, E. and Lieber, C.S., High blood alcohol levels in women: role of decreased gastric alcohol dehydrogenase activity and first pass metabolism of ethanol, New Eng. Journ. Med., 322:95-99, 1990.
    • (1990) New Eng. Journ. Med. , vol.322 , pp. 95-99
    • Frezza, A.1    DiPadova, C.2    Pozzato, G.3    Terpin, M.4    Baraona, E.5    Lieber, C.S.6
  • 7
    • 0003478294 scopus 로고
    • Male and female intoxication levies for three alcohol doses or do women really get higher than men
    • Jones, B.M. and Jones, M.R., Male and female intoxication levies for three alcohol doses or do women really get higher than men?, Alcohol Tech. Report, 5:11-14, 1976.
    • (1976) Alcohol Tech. Report , vol.5 , pp. 11-14
    • Jones, B.M.1    Jones, M.R.2
  • 8
    • 0031012252 scopus 로고    scopus 로고
    • Alcohol and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients
    • Chao, Y.C., Young, T.H., Tang, H.S. and Hsu, C.T., Alcohol and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients, Hepatol, 25(1): 112-117, 1997.
    • (1997) Hepatol , vol.25 , Issue.1 , pp. 112-117
    • Chao, Y.C.1    Young, T.H.2    Tang, H.S.3    Hsu, C.T.4
  • 9
    • 0019858441 scopus 로고
    • Racial differences in biological sensitivity to ethanol: The role of alcohol dehydrogenase and aldehyde dehydrogenase
    • Agarwal, D.P., Harada, S. and Goedde, H.W., Racial differences in biological sensitivity to ethanol: The role of alcohol dehydrogenase and aldehyde dehydrogenase, Alcohol.: CLin. Exper. Res., 5(1):12-16, 1981.
    • (1981) Alcohol.: Clin. Exper. Res. , vol.5 , Issue.1 , pp. 12-16
    • Agarwal, D.P.1    Harada, S.2    Goedde, H.W.3
  • 11
    • 0022543084 scopus 로고
    • Genetic polymorphisms of human alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism
    • Bosron, W. and Li, T.K., Genetic polymorphisms of human alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism, Hepat., 6(3): 502-510, 1986.
    • (1986) Hepat. , vol.6 , Issue.3 , pp. 502-510
    • Bosron, W.1    Li, T.K.2
  • 12
    • 0025060396 scopus 로고
    • Pharmacogenetics of alcohol dehydrogenase
    • Agarwal, D. and Goedde, H., Pharmacogenetics of alcohol dehydrogenase, Pharm. Ther., 45:69-83, 1990.
    • (1990) Pharm. Ther. , vol.45 , pp. 69-83
    • Agarwal, D.1    Goedde, H.2
  • 15
    • 0021715188 scopus 로고
    • Human liver alcohol dehyrogenase: Purification and kinetic characterization of the β2β2, β2β1 αβ2 and β2γ1 "Oriental Isoenzymes
    • Yin, S.J., Bosron, W., Magnes, L. and Li, T.K., Human liver alcohol dehyrogenase: Purification and kinetic characterization of the β2β2, β2β1 αβ2 and β2γ1 "Oriental Isoenzymes, Biochem., 23:5847-5853, 1984a.
    • (1984) Biochem. , vol.23 , pp. 5847-5853
    • Yin, S.J.1    Bosron, W.2    Magnes, L.3    Li, T.K.4
  • 16
    • 0025793694 scopus 로고
    • Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51
    • H. Weiner, Editor. Plenum Press: New York.
    • Hurley, T., Ehrig, T., Edenberg, H. and Bosron, W., Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51, in Enzymol Mol. Bio. of Carbonyl Metabolism 3, H. Weiner, Editor. 1990, Plenum Press: New York. p. 271-274.
    • (1990) Enzymol Mol. Bio. of Carbonyl Metabolism , vol.3 , pp. 271-274
    • Hurley, T.1    Ehrig, T.2    Edenberg, H.3    Bosron, W.4
  • 17
    • 0023772630 scopus 로고
    • Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-s locus
    • Ikuta, T., Shibuya, A. and Yoshida, A., Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-s locus, Biochem. Genet., 26(7/8):519-525, 1988.
    • (1988) Biochem. Genet. , vol.26 , Issue.7-8 , pp. 519-525
    • Ikuta, T.1    Shibuya, A.2    Yoshida, A.3
  • 18
    • 0022362003 scopus 로고
    • Human liver alcohol dehydrogenase: The unique properties of the "atypical" isoenzyme β22 can be explained by a single base pair mutation
    • Buhler, R., Hempel, J., Wartburg, J.P.v. and Jornvall, H., Human liver alcohol dehydrogenase: the unique properties of the "atypical" isoenzyme β22 can be explained by a single base pair mutation, Alcohol, 2:47-51, 1985.
    • (1985) Alcohol , vol.2 , pp. 47-51
    • Buhler, R.1    Hempel, J.2    Wartburg, J.P.V.3    Jornvall, H.4
  • 19
    • 0024451123 scopus 로고
    • Purification and steady state kinetic characterization of human b3b3 alcohol dehydrogenase
    • Burnell, J., Li, T.K. and Bosron, W., Purification and steady state kinetic characterization of human b3b3 alcohol dehydrogenase, Biochem., 28:6810-6815, 1989.
    • (1989) Biochem. , vol.28 , pp. 6810-6815
    • Burnell, J.1    Li, T.K.2    Bosron, W.3
  • 20
    • 0015009635 scopus 로고
    • Developmetnal changes and polymorphism in human alcohol dehydrogenase
    • Smith, M., Hopkinson, D.A. and Harris, H., Developmetnal changes and polymorphism in human alcohol dehydrogenase, Amer. Jour. Genet. Lond., 34:251-271, 1971.
    • (1971) Amer. Jour. Genet. Lond. , vol.34 , pp. 251-271
    • Smith, M.1    Hopkinson, D.A.2    Harris, H.3
  • 21
    • 0031051848 scopus 로고    scopus 로고
    • Human stomach alcohol and aldehyde dehydrogenase: Comparison of of expression pattern and activities in alimentary tract
    • Yin, S.J., Liao, C.S., Wu, C.W., Li, T.T., Chen, L.L., Lai, C.L. and Tsao, T.Y., Human stomach alcohol and aldehyde dehydrogenase: comparison of of expression pattern and activities in alimentary tract, Gastroenterol., 112:766-775, 1997.
    • (1997) Gastroenterol. , vol.112 , pp. 766-775
    • Yin, S.J.1    Liao, C.S.2    Wu, C.W.3    Li, T.T.4    Chen, L.L.5    Lai, C.L.6    Tsao, T.Y.7
  • 23
    • 0345240594 scopus 로고
    • Human liver alcohol dehydrogenase: Amino acid substitution in the β2β2 Oriental enzyme explains functional propeties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme
    • Jornvall, H., Hempel, J., Vallee, B.L., Bosron, W. and Li, T.K., Human liver alcohol dehydrogenase: Amino acid substitution in the β2β2 Oriental enzyme explains functional propeties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme, Proc. Natl. Acad. Scie., 81:3024-3028, 1984.
    • (1984) Proc. Natl. Acad. Scie. , vol.81 , pp. 3024-3028
    • Jornvall, H.1    Hempel, J.2    Vallee, B.L.3    Bosron, W.4    Li, T.K.5
  • 24
    • 0015025833 scopus 로고
    • Genetic and environmental factors affecting ethanol metabolism in man
    • Vesell, E., Page, J. and Passananti, G., Genetic and environmental factors affecting ethanol metabolism in man. Clin. Pharm. Ther., 12:192-201, 1971.
    • (1971) Clin. Pharm. Ther. , vol.12 , pp. 192-201
    • Vesell, E.1    Page, J.2    Passananti, G.3
  • 25
    • 0023626928 scopus 로고
    • Clincal pharmacokinetics of ethanol
    • Holford, N.H., Clincal pharmacokinetics of ethanol, Clin. Pharmacokin., 13:273-292, 1987.
    • (1987) Clin. Pharmacokin. , vol.13 , pp. 273-292
    • Holford, N.H.1
  • 26
    • 0031194870 scopus 로고    scopus 로고
    • Comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats and humans
    • Pastino, G., Asgharian, B., Roberts, K., Medinsky, M. and Bond, J., Comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats and humans, Tox. Appl. Pharm., 145:147-157, 1997.
    • (1997) Tox. Appl. Pharm. , vol.145 , pp. 147-157
    • Pastino, G.1    Asgharian, B.2    Roberts, K.3    Medinsky, M.4    Bond, J.5
  • 28
    • 0028256204 scopus 로고
    • Partition Coefficients of some acetate esters and alcohols in water, blood, olive oil and rat tissues
    • Kaneko, T., Wang, P. and Sato, A., Partition Coefficients of some acetate esters and alcohols in water, blood, olive oil and rat tissues, Occup. Environ. Med., 51:68-72, 1994.
    • (1994) Occup. Environ. Med. , vol.51 , pp. 68-72
    • Kaneko, T.1    Wang, P.2    Sato, A.3
  • 29
    • 0030694692 scopus 로고    scopus 로고
    • A physiolgically based pharmacokinetic model for trichlorethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice,
    • Abbas, R. and Fisher, J.W., A physiolgically based pharmacokinetic model for trichlorethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice, Tox. Appl. Pharm., 147:15-30, 1997.
    • (1997) Tox. Appl. Pharm. , vol.147 , pp. 15-30
    • Abbas, R.1    Fisher, J.W.2
  • 30
    • 0027365787 scopus 로고
    • Simulation studies on ethanol metabolism in different human populations with a physiologic pharmacokinetic model
    • Derr, R., Simulation studies on ethanol metabolism in different human populations with a physiologic pharmacokinetic model, Jour. Pharm. Scie., 82(7):677-682, 1993.
    • (1993) Jour. Pharm. Scie. , vol.82 , Issue.7 , pp. 677-682
    • Derr, R.1
  • 31
    • 0343076571 scopus 로고    scopus 로고
    • Application of a physiologically based pharmacokinetic model for ethanol to quantify the bioavailability in male rats
    • Pastino, G. and Conolly, R., Application of a physiologically based pharmacokinetic model for ethanol to quantify the bioavailability in male rats, The Toxicologist, ,1998.
    • (1998) The Toxicologist
    • Pastino, G.1    Conolly, R.2
  • 33
    • 0029587495 scopus 로고
    • ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics
    • Thomason, H., Beard, J. and Li, T.K., ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics, Alcohol.: Clin. Exper. Res., 19(6):1494-1495, 1995.
    • (1995) Alcohol.: Clin. Exper. Res. , vol.19 , Issue.6 , pp. 1494-1495
    • Thomason, H.1    Beard, J.2    Li, T.K.3
  • 34
    • 0023129425 scopus 로고
    • Catalytic properties of human liver alcohol dehydrogenase isozymes
    • Bosron, W. and Li, T.K., Catalytic properties of human liver alcohol dehydrogenase isozymes, Enzyme, 37:19-28, 1987.
    • (1987) Enzyme , vol.37 , pp. 19-28
    • Bosron, W.1    Li, T.K.2
  • 35
    • 0343076570 scopus 로고    scopus 로고
    • Ethanol metabolism in the gastrointestinal tract and its possible consequences
    • J.B. Saunders and J.B. Whitfield, Eds. Pergamon Press: New York.
    • Seitz, H.K., Gartner, U., Egerer, G. and Simanowski, U.A., Ethanol metabolism in the gastrointestinal tract and its possible consequences., in Biology of alcohol related problems., J.B. Saunders and J.B. Whitfield, Eds. 1996, Pergamon Press: New York. p. 157-162.
    • (1996) Biology of Alcohol Related Problems , pp. 157-162
    • Seitz, H.K.1    Gartner, U.2    Egerer, G.3    Simanowski, U.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.