Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians

American Journal of Psychiatry

Volumn 160, Issue 1, 2003, Pages 41-46

  Wall, Tamara L ^a,b,c,d   Carr, Lucinda G ^a,b,c,d   Ehlers, Cindy L ^a,b,c,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ISOENZYME;

ADULT; AGED; ALCOHOLISM; ALLELE; AMERICAN INDIAN; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ALLELES; CALIFORNIA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIANS, NORTH AMERICAN; MALE; MIDDLE AGED; MISSIONS AND MISSIONARIES; PHENOTYPE; POLYMORPHISM, GENETIC; RISK FACTORS; VARIATION (GENETICS);

EID: 0037225850     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.1.41     Document Type: Article

References (59)

1. Bosron WF, Ehrig T, Li T-K: Genetic factors in alcohol metabolism and alcoholism. Semin Liver Dis 1993; 13:126-135
2. Crabb DW, Dipple KM, Thomasson HR: Alcohol sensitivity, alcohol metabolism, risk for alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes. J Lab Clin Med 1993; 122:234-240
3. Chen Y-C, Lu R-B, Peng G-S, Wang M-F, Wang H-K, Ko H-C, Chang Y-C, Lu J-J, Li T-K, Yin S-J: Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. Alcohol Clin Exp Res 1999; 23:1853-1860
4. Chen C-C, Lu R-B, Chen Y-C, Wang M-F, Chang Y-C, Li T-K, Yin S-J: Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am J Hum Genet 1999; 65:795-807
5. Higuchi S, Matsushita S, Murayama M, Takagi S, Hayashida M: Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 1995; 152:1219-1221
6. Thomasson HR, Edenberg HJ, Crabb DW, Mai X-L, Jerome RE, Li T-K, Wang S-P, Lin Y-T, Lu R-B, Yin S-J: Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991; 48:667-681
7. Chen WJ, Loh EW, Hsu Y-PP, Chen C-C, Yu J-M, Cheng ATA: Alcohol-metabolizing genes and alcoholism among Taiwanese Han men: Independent effect of ADH2, ADH3, and ALDH2. Br J Psychiatry 1996; 168:762-767
8. Iwahashi K: Heterozygous for ALDH2 in alcohol dependence: Relationship between the ALDH2 genotype and personality disorder in alcohol-dependent patients with the flushing syndrome (letter). Biol Psychiatry 1995; 37:137
9. Maezawa Y, Yamauchi M, Toda G, Suzuki H, Sakurai S: Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res 1995; 19:951-954
10. Muramatsu T, Wang Z-C, Fang Y-R, Hu K-B, Hequin Y, Yamada K, Higuchi S, Harada S, Kono H: Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Chinese living in Shanghai. Hum Genet 1995; 96:151-154
11. Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, Ichikawa Y, Suwaki H: Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2: A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res 1996; 20:52-55
12. Shen Y-C, Fan J-H, Edenberg HJ, Li T-K, Cui Y-H, Wang Y-F, Tian C-H, Zhou C-G, Zhou R-L, Wang J, Zhao Z-L, Xia G-Y: Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 1997; 21:1272-1277
13. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M: High incidence of ADH2*1/ALDH2*1 genes among Japanese dependents and patients with alcoholic liver disease. Hepatology 1996; 23:234-239
14. Enomoto N, Takase S, Yasuhara M, Takada A: Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 1991; 15:141-144
15. Mizoi Y, Yamamoto K, Ueno Y, Fukunaga T, Harada S: Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 1994; 29:707-710
16. Peng G-S, Wang M-F, Chen CY, Luu S-Y, Chau H-C, Li T-K, Yin S-J: Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics 1999; 9:463-476
17. Takeshita T, Morimoto K: Accumulation of hemoglobin-associated acetaldehyde with habitual drinking in the atypical ALDH2 genotype. Alcohol Clin Exp Res 2000; 24:1-7
18. Wall TL, Peterson CM, Peterson KP, Johnson ML, Thomasson HR, Cole M, Ehlers CL: Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med 1997; 127:376-379
19. Yoshihara E, Ameno K, Nakamura K, Ameno M, Itoh S, Ijiri I, Iwahasi K: The effects of the ALDH2*1/2, CYP2E2E1 C1/C2 and C/D genotypes on blood ethanol elimination. Drug Chem Toxicol 2000; 23:371-379
20. Wall TL, Thomasson HR, Schuckit MA, Ehlers CL: Subjective feelings of alcohol intoxication in Asians with genetic variations of ALDH2 alleles. Alcohol Clin Exp Res 1992; 16:991-995
21. Luczak SE, Elvine-Kreis B, Shea SH, Carr LG, Wall TL: Genetic risk for alcoholism relates to level of response to alcohol in Asian American men and women. J Stud Alcohol 2002; 63:74-82
22. Higuchi S, Matsushita S, Muramatsu T, Murayama M, Hayashida M: Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. Alcohol Clin Exp Res 1996; 20:493-497
23. Sun F, Tsuritani I, Honda R, Ma Z-M, Yamada Y: Association of genetic polymorphisms of alcohol metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum Genet 1999; 105:295-300
24. Takeshita T, Morimoto K: Self-reported alcohol-associated symptoms and drinking behavior in three ALDH2 genotypes among Japanese university students. Alcohol Clin Exp Res 1999; 23:1065-1069
25. Takeshita T, Morimoto K, Mao XQ, Hashimoto T, Furuyama J: Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. Hum Genet 1994; 94:217-223
26. Chen WJ, Loh EW, Hsu Y-PP, Cheng ATA: Alcohol dehydrogenase and aldehyde dehydrogenase and alcoholism among Taiwanese aborigines. Biol Psychiatry 1997; 41:703-709
27. Thomasson HR, Crabb DW, Edenberg HJ, Li T-K, Hwu H-G, Chen C-C, Yeh E-K, Yin S-J: Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 1994; 18:640-643
28. Borras E, Coutelle C, Rosell A, Fernandez-Muixi F, Broch M, Crosas B, Hjelmqvist L, Lorenzo A, Gutierrez C, Santos M, Szczepanek M, Heilig M, Quattrocchi P, Farres J, Vidal F, Richart C, Mach T, Bogdal J, Jornvall H, Seitz HK, Couzigou P, Pares X: Genetic polymorphisms of alcohol dehydrogenase in Europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 2000; 31:984-989
29. Whitfield JB, Nightingale BN, Bucholz KK, Madden PAF, Heath AC, Martin NG: ADH genotypes and alcohol use and dependence in Europeans. Alcohol Clin Exp Res 1998; 22:1463-1469
30. Neumark YD, Friedlander Y, Thomasson HR, Li T-K: Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel. J Stud Alcohol 1998; 59:133-139
31. Shea SH, Wall TL, Carr LG, Li T-K: ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. Behav Genet 2001; 31:231-239
32. Whitfield JB: Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence. Alcohol Alcohol 1997; 32:613-619
33. Thomasson HR, Beard JD, Li T-K: ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol Clin Exp Res 1995; 19:1494-1499
34. McCarver DG, Thomasson HR, Martier SS, Sokol RJ, Li T-K: Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans. J Pharmacol Exp Ther 1997; 283:1095-1101
35. Viljoen DL, Carr LG, Foroud TM, Brooke L, Ramsay M, Li T-K: Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. Alcohol Clin Exp Res 2001; 25:1719-1722
36. Wall TL, Garcia-Andrade C, Thomasson HR, Carr LG, Ehlers CL: Alcohol dehydrogenase polymorphisms in Native Americans: Identification of the ADH2*3 allele. Alcohol Alcohol 1997; 32:129-132
37. Ehlers CL, Gilder DA, Harris L, Carr L: Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. Alcohol Clin Exp Res 2001; 25:1773-1777
38. Osier M, Pakstis AJ, Kidd JR, Lee J-F, Yin S-J, Ko H-C, Edenberg HJ, Lu R-B, Kidd KK: Linkage disequilibrium at the ADH2 and ADH3 loci and risk for alcoholism. Am J Hum Genet 1999; 64:1147-1157
39. Tsukahara M, Yoshida A: Chromosomal assignment of the alcohol dehydrogenase cluster to human chromosome 4q21-23 by in situ hybridization. Genomics 1989; 4:218-220
40. Yasunami M, Kikuchi I, Sarapata D, Yoshida A: The human class I alcohol dehydrogenase gene cluster: Three genes are tandemly organized in an 80-kb-long segment of the genome. Genomics 1990; 7:152-158
41. Thomasson HR, Crabb DW, Edenberg HJ, Li T-K: Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 1993; 23:131-136
42. Wall TL, Garcia-Andrade C, Thomasson HR, Cole M, Ehlers CL: Alcohol elimination in Native American Mission Indians: An investigation of interindividual variation. Alcohol Clin Exp Res 1996; 20:1438-1442
43. Jacobson SW, Chiodo L, Jester J, Carr L, Sokol R, Jacobson J, Li T-K: Protective effects of ADH2*3 in African American infants exposed to prenatally to alcohol (abstract). Alcohol Clin Exp Res 2000; 24(suppl 5):28A
44. Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, Li T-K, Begleiter H, Reich T, Rice JP: A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet 2000; 96:632-637
45. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI, Reich T, Schmidt I, Schuckit MA: A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. J Stud Alcohol 1994; 55:149-158
46. Bucholz KK, Hesselbrock VM, Shayka JJ, Nurnberger JI, Schuckit MA, Reich T: Reliability of individual diagnostic criterion for psychoactive substance dependence and the impact on diagnosis. J Stud Alcohol 1995; 56:500-505
47. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V: A validity study of the SSAGA: A comparison with the SCAN. Addiction 1999; 94:1361-1370
48. Crabb DW, Edenberg HJ, Bosron WF, Li T-K: Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity: The inactive ALDH2(2) allele is dominant. J Clin Invest 1989; 83:314-316
49. Xu Y, Carr LG, Bosron WF, Li T-K, Edenberg HJ: Genotyping of human alcohol dehydrogenase at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 1988; 2:209-214
50. Waldman IW, Robinson BF, Rhee SH: A logistic regression extension of the transmission disequilibrium test for continuous traits: Application to linkage disequilibrium between alcoholism and candidate genes DRD2 and ADH3. Genet Epidemiol 1999; 17:S379-S384
51. Gill K, Elk ME, Deitrich RA: A description of alcohol/drug use and family history of alcoholism among urban American Indians. Am Indian Alsk Native Ment Health Res 1997; 8:41-52
52. Kunitz SJ, Gabriel KR, Levy JE, Henderson E, Lampert K, McCloskey J, Quintero G, Russell S, Vince A: Alcohol dependence and conduct disorder among Navajo Indians. J Stud Alcohol 1999; 60:159-167
53. Robin RW, Long JC, Rasmussen JK, Albaugh B, Goldman D: Relationship of binge drinking to alcohol dependence, other psychiatric disorders, and behavioral problems in an American Indian tribe. Alcohol Clin Exp Res 1998; 22:518-523
54. Wall TL, Shea SH, Chan KK, Carr LG: A genetic association with the development of alcohol and other substance use behavior in Asian Americans. J Abnorm Psychol 2001; 110:173-178
55. Reich T, Edenberg HJ, Goate A, William JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li T-K, Conneally PM, Nurnberger JI, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H: Genome-wide search for genes affecting risk for alcohol dependence. Am J Med Genet Neuropsychiatr Genet 1998; 81:206-215
56. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D: Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet Neuropsychiatr Genet 1998; 81:216-221
57. McCarver DG: ADH2 and CYP2E1 genetic polymorphisms: Risk factors for alcohol-related birth defects. Drug Metab Dispos 2001; 29:562-565
58. Whitfield JB, Zhu G, Duffy DL, Birley AJ, Madden PAF, Heath AC, Martin NG: Variation in alcohol pharmacokinetics as a risk factor for alcohol dependence. Alcohol Clin Exp Res 2001; 25:1257-1263
59. Heath AC, Madden PAF, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Rohrbaugh JW, Statham DJ, Dunne MP, Whitfield JB, Martin NG: Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 1999; 29:1069-1081