Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts

Biological Psychiatry

Volumn 54, Issue 12, 2003, Pages 1422-1426

  Schumann, Gunter ^a   Rujescu, Dan ^b   Kissling, Christian ^a   Soyka, Michael ^b   Dahmen, Norbert ^c   Preuss, Ullrich W ^b   Wieman, Stefan ^d   Depner, Martin ^a   Wellek, Stefan ^a   Lascorz, Jesús ^a   Bondy, Brigitta ^b   Giegling, Ina ^b   Anghelescu, Ion ^e   Cowen, Michael S ^a   Poustka, Annemarie ^d   Spanagel, Rainer ^a   Mann, Karl ^a   Henn, Fritz A ^a   Szegedi, Armin ^c  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alcohol dependence; Alcohol intake; Association; Early onset; Linkage disequilibrium; Protein tyrosine kinase fyn; Withdrawal

Indexed keywords

PROTEIN KINASE FYN;

5' UNTRANSLATED REGION; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SAMPLING; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 10744234007     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00635-8     Document Type: Article

References (17)

1. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics. 11:1955;375-386.
2. Boyle J.M., Hey Y., Myers K., Stern P.L., Grzeschik F.H., Ikehara Y., et al. Regional localization of a trophoblast antigen-related sequence and 16 other sequences to human chromosomes 6q using somatic cell hybrids. Genomics. 12:1992;693-698.
3. Brookes A.J., Lehvaslaiho H., Siegfried M., Boehm J.G., Yuan Y.P., Sarkar C.M., et al. HGBASE A database of SNPs and other variations in and around human genes . Nucleic Acids Res. 28:2000;356-360.
4. Bucholz K.K., Cadoret R., Cloninger C.R., Dinwiddie S.H., Hesselbrock V.M., Nurnberger J.I. Jr, et al. A new, semi-structured psychiatric interview for use in genetic linkage studies A report on the reliability of the SSAGA . J Stud Alcohol. 55:1994;149-158.
5. Cantor R.M., Lanning C.D. Comparison of evidence supporting a chromosome 6 alcoholism gene. Genet Epidemiol. 17:(suppl 1):1999;S91-S96.
6. Devlin B., Roeder K. Genomic control for association studies. Biometrics. 55:1999;997-1004.
7. Fadda F., Rossetti Z.L. Chronic ethanol consumption From neuroadaptation to neurodegeneration . Prog Neurobiol. 56:1998;385-431.
8. Fink K., Gothert M. Both ethanol and ifenprodil inhibit NMDA-evoked release of various neurotransmitters at different, yet proportional potency Potential relation to NMDA receptor subunit composition . Naunyn Schmiedebergs Arch Pharmacol. 354:1996;312-319.
9. Ishiguro H., Saito T., Shibuya H., Toru M., Arinami T. Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. Am J Med Genet. 96:2000;716-720.
10. Masood K., Wu C., Brauneis U., Weight F.F. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol. 45:1994;324-329.
11. Miyakawa T., Yagi T., Kitazawa H., Yasuda M., Kawai N., Tsuboi K., et al. Fyn-kinase as a determinant of ethanol sensitivity Relation to NMDA-receptor function . Science. 278:1997;698-701.
12. Schuckit M.A., Smith T.L. An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry. 53:1996;202-210.
13. Selzer M.L. Michigan Alcoholism Screening Test The quest for a new diagnostic instrument . Am J Psychiatry. 127:1971;1653-1658.
14. Spanagel R, Bienkowski P (2002): Alcohol dependence and addiction. In: Lodge D, Danysz W, Parsons CG, editors. Ionotropic Glutamate Receptors as Therapeutic Targets. Johnson City, TN: F.P. Graham Publishing Co., 375-403.
15. Tezuka T., Umemori H., Akiyama T., Nakanishi S., Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D- aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 96:1999;435-440.
16. Tsai G., Coyle J.T. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med. 49:1998;173-184.
17. Wittchen H.U. Reliability and validity studies of the WHO Composite International Diagnostic Interview (CIDI) A critical review . J Psychiatr Res. 28:1994;57-84.