Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice

Trends in Neurosciences

Volumn 29, Issue 4, 2006, Pages 233-240

  Vitaterna, Martha Hotz ^a   Pinto, Lawrence H ^a   Takahashi, Joseph S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL BEHAVIOR; COMPARATIVE STUDY; DNA POLYMORPHISM; DROSOPHILA; EXPERIMENTAL MOUSE; GENETIC SCREENING; GENOME ANALYSIS; MAMMAL; MOLECULAR CLONING; MOUSE MUTANT; NERVOUS SYSTEM; NEUROSCIENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; REVIEW; SITE DIRECTED MUTAGENESIS;

ANIMALS; BEHAVIOR, ANIMAL; CHROMOSOME MAPPING; GENETICS, BEHAVIORAL; GENOMICS; INTERINSTITUTIONAL RELATIONS; MICE; MICE, MUTANT STRAINS; MUTAGENESIS; NATIONAL INSTITUTES OF HEALTH (U.S.); PHENOTYPE; QUANTITATIVE TRAIT LOCI; RESEARCH DESIGN; UNITED STATES;

EID: 33645961290     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2006.02.006     Document Type: Review

References (71)

1. Collins F.S., et al. New goals for the U.S. Human Genome Project: 1998-2003. Science 282 (1998) 682-689
2. Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
3. Waterston R.H., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420 (2002) 520-562
4. Gibbs R.A., et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428 (2004) 493-521
5. Wheeler D.L., et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 33 Database issue (2005) D39-D45
6. Benson D.A., et al. GenBank. Nucleic Acids Res. 33 Database issue (2005) D34-D38
7. Hubbard T., et al. Ensembl 2005. Nucleic Acids Res. 33 Database issue (2005) D447-D453
8. Frazer K.A., et al. Cross-species sequence comparisons: a review of methods and available resources. Genome Res. 13 (2003) 1-12
9. Ureta-Vidal A., et al. Comparative genomics: genome-wide analysis in metazoan eukaryotes. Nat. Rev. Genet. 4 (2003) 251-262
10. Bradley A. Mining the mouse genome. Nature 420 (2002) 512-514
11. Dietrich W.F., et al. A comprehensive genetic map of the mouse genome. Nature 380 (1996) 149-152
12. Lindblad-Toh K., et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat. Genet. 24 (2000) 381-386
13. Gregory S.G., et al. A physical map of the mouse genome. Nature 418 (2002) 743-750
14. Okazaki Y., et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420 (2002) 563-573
15. Brown P.O., and Botstein D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21 (1999) 33-37
16. Lipshutz R.J., et al. High density synthetic oligonucleotide arrays. Nat. Genet. 21 (1999) 20-24
17. Merikangas K.R., et al. Future of genetics of mood disorders research. Biol. Psychiatry 52 (2002) 457-477
18. Santangelo S.L., and Tsatsanis K. What is known about autism: genes, brain, and behavior. Am. J. Pharmacogenomics 5 (2005) 71-92
19. Kreek M.J., et al. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev. 57 (2005) 1-26
20. Pinto L.H., et al. Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus. Vision Res. 44 (2004) 3335-3345
21. Takahashi J.S., et al. Forward and reverse genetic approaches to behavior in the mouse. Science 264 (1994) 1724-1733
22. Paigen K. A miracle enough: the power of mice. Nat. Med. 1 (1995) 215-220
23. Nadeau J.H., et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science 291 (2001) 1251-1255
24. Brown S.D., and Peters J. Combining mutagenesis and genomics in the mouse - closing the phenotype gap. Trends Genet. 12 (1996) 433-435
25. Bullard D.C. Mind the phenotype gap. Trends Mol. Med. 7 (2001) 537-538
26. Pinto L.H., and Takahashi J.S. Functional identification of neural genes. In: Chin H.R., and Moldin S.O. (Eds). Methods in Genomic Neuroscience (2001), CRC Press 65-90
27. Tarantino L.M., and Bucan M. Dissection of behavior and psychiatric disorders using the mouse as a model. Hum. Mol. Genet. 9 (2000) 953-965
28. Bucan M., and Abel T. The mouse: genetics meets behaviour. Nat. Rev. Genet. 3 (2002) 114-123
29. Matynia A., et al. Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory. Annu. Rev. Genet. 36 (2002) 687-720
30. Tronche F., et al. When reverse genetics meets physiology: the use of site-specific recombinases in mice. FEBS Lett. 529 (2002) 116-121
31. Hotta Y., and Benzer S. Abnormal electroretinograms in visual mutants of Drosophila. Nature 222 (1969) 354-356
32. Konopka R.J., and Benzer S. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. U. S. A. 68 (1971) 2112-2116
33. Nusslein-Volhard C., and Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 287 (1980) 795-801
34. Zipursky S.L., and Rubin G.M. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17 (1994) 373-397
35. Pak W.L. Drosophila in vision research. The Friedenwald Lecture. Invest. Ophthalmol. Vis. Sci. 36 (1995) 2340-2357
36. Collins F.S. Positional cloning moves from perditional to traditional. Nat. Genet. 9 (1995) 347-350
37. Rajan R.S., and Kopito R.R. Suppression of wild-type rhodopsin maturation by mutants linked to autosomal dominant retinitis pigmentosa. J. Biol. Chem. 280 (2005) 1284-1291
38. + channel GIRK2. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 923-927
39. Jensen P., et al. Rescue of cerebellar granule cells from death in weaver NR1 double mutants. J. Neurosci. 19 (1999) 7991-7998
40. Patrucco E., et al. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118 (2004) 375-387
41. Halaas J.L., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
42. Antoch M.P., et al. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89 (1997) 655-667
43. King D.P., et al. Positional cloning of the mouse circadian Clock gene. Cell 89 (1997) 641-653
44. Vitaterna M.H., et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264 (1994) 719-725
45. Austin C.P., et al. The knockout mouse project. Nat. Genet. 36 (2004) 921-924
46. Flint J., et al. Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6 (2005) 271-286
47. Wade C.M., et al. The mosaic structure of variation in the laboratory mouse genome. Nature 420 (2002) 574-578
48. Wiltshire T., et al. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 3380-3385
49. Pletcher M.T., et al. Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol. 2 (2004) e393
50. Shimomura K., et al. Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res. 11 (2001) 959-980
51. Chesler E.J., et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37 (2005) 233-242
52. Churchill G.A., et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat. Genet. 36 (2004) 1133-1137
53. Silva A.J., et al. Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. Neuron 19 (1997) 755-759
54. Wolfer D.P., et al. Knockout mice: simple solutions to the problems of genetic background and flanking genes. Trends Neurosci. 25 (2002) 336-340
55. Dietrich W.F., et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75 (1993) 631-639
56. Hrabe de Angelis M.H., et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat. Genet. 25 (2000) 444-447
57. Nolan P.M., et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 25 (2000) 440-443
58. Rogers D.C., et al. Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm. Genome 8 (1997) 711-713
59. Moldin S.O., et al. Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis. Mamm. Genome 12 (2001) 575-581
60. Shedlovsky A., et al. Induction of recessive lethal mutations in the T/t-H-2 region of the mouse genome by a point mutagen. Genet. Res. 47 (1986) 135-142
61. Pittendrigh C.S. Temporal organization: reflections of a Darwinian clock-watcher. Annu. Rev. Physiol. 55 (1993) 16-54
62. Pinto L.H., et al. Generation, characterization and molecular cloning of the Noerg-1 mutation in the mouse. Vis. Neurosci. 22 (2005) 619-629
63. 19H deletion, distal of Kit. Genetics 146 (1997) 1049-1060
64. Stenson P.D., et al. Human Gene Mutation Database (HGMD): 2003 update. Hum. Mutat. 21 (2003) 577-581
65. Naylor E., et al. The circadian Clock mutation alters sleep homeostasis in the mouse. J. Neurosci. 20 (2000) 8138-8143
66. Gorbacheva V.Y., et al. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 3407-3412
67. Easton A., et al. The circadian Clock mutation increases exploratory activity and escape-seeking behavior. Genes Brain Behav. 2 (2003) 11-19
68. McClung C.A., et al. Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 9377-9381
69. Turek F.W., et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308 (2005) 1043-1045
70. Siepka S.M., and Takahashi J.S. Methods to record circadian rhythm wheel running activity in mice. Methods Enzymol. 393 (2005) 230-239
71. Siepka S.M., and Takahashi J.S. Forward genetic screens to identify circadian rhythm mutants in mice. Methods Enzymol. 393 (2005) 219-229