Role of 16S rRNA helix 44 in ribosomal resistance to hygromycin B

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 5, 2003, Pages 1496-1502

  Pfister, P ^a   Risch, M ^a   Brodersen, D E ^b   Bottger E C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; HYGROMYCIN B; RECA PROTEIN; RNA 16S;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG BINDING SITE; DRUG STRUCTURE; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RIBOSOME;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; HYGROMYCIN B; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; POINT MUTATION; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S;

EID: 0038674297     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.5.1496-1502.2003     Document Type: Article

References (39)

1. Anderson, R. M. 1999. The pandemic of antibiotic resistance. Nat. Med. 5:147-149.
2. Bakker, E. P. 1992. Aminoglycoside and aminocyclitol antibiotics: hygromycin B is an atypical bactericidal compound that exerts effects on cells of Escherichia coli characteristic for bacteriostatic aminocyditols. J. Gen. Microbiol. 138:563-569.
3. Böttger E. C., B. Springer, T. Prammananan, Y. Kidan, and P. Sander. 2001. Structural basis for selectivity and toxicity of ribosomal antibiotics. EMBO Rep. 2:318-323.
4. Brodersen, D. E., W. M. Clemons, Jr., A. P. Carter, R. J. Morgan-Warren, B. T. Wimberly, and V. Ramakrishnan. 2000. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-1154.
5. Cabanas, M. J., D. Vasquez, and J. Modolell. 1978. Dual interference of hygromycin B with ribosomal translocation and with aminoacyl-tRNA recognition. Eur. J. Biochem. 87:21-27.
6. Canino, R., P. Contursi, M. Rossi, and S. Bartolucci. 1998. An autonomously replicating transforming vector for Sulfolobus solfataricus. J. Bacteriol. 180:3237-3240.
7. Carson, M. 1991. Ribbons 2.0. J. Appl. Crystallogr. 24:958-961.
8. Carter, A. P., W. M. Clemons, Jr., D. E. Brodersen, R. J. Morgan-Warren, B. T. Wimberly, and V. Ramakrishnan. 2000. Functional insights from the structure of the 30S subunit and its interactions with antibiotics. Nature 407:340-348.
9. Davies, J., L. Gorini, and B. D. Davis. 1965. Misreading of RNA codewords induced by aminoglycoside antibiotics. Mol. Pharmacol. 1:93-106.
10. De Stasio, E. A., D. Moazed, H. F. Noller, and A. E. Dahlberg. 1989. Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions. EMBO J. 8:1213-1216.
11. Eustice, D. C., and J. M. Wilhelm. 1984. Fidelity of the eukaryotic codonanticodon interaction: interference by aminoglycoside antibiotics. Biochemistry 23:1462-1467.
12. Fourmy, D., M. I. Recht, S. C. Blanchard, and J. D. Puglisi. 1996. Structure of the A site of E. coli 16S rRNA complexed with an aminoglycoside antibiotic. Science 274:1367-1371.
13. Frank, J., and R. K. Agrawal. 2000. A ratchet-like intersubunit reorganization of the ribosome during translocation. Nature 408:318-322.
14. Gale, E. F., E. Cundliffe, P. E. Reynolds, M. H. Richmond, and J. M. Waring (ed.). 1981. The molecular basis of antibiotic action. John Wiley & Sons, Inc., New York, N.Y.
15. Ganoza, M. C., and M. C. Kiel. 2001. A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes. Antimicrob. Agents Chemother. 45:2813-2819.
16. Gonzales, A., A. Jimenez, D. Vasquez, J. E. Davies, and D. Schindler. 1978. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochem. Biophys. Acta 521:459-469.
17. Hansen, J. L., J. A. Ippolito, N. Ban, P. Nissen, P. B. Moore, and T. A. Steitz. 2002. The structure of four macrolide antibiotics bound to the large ribosomal subunit. Mol. Cell 10:117-128.
18. Kojic, M., N. Milojevic, and B. Vasiljevic. 1999. Gentamicin-resistance determinants confer background-dependent hygromycin B resistance. Microb. Drug Resist 5:177-182.
19. Moazed, D., and H. F. Noller. 1987. Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature 327:389-394.
20. Noller, H. F. 1991. Ribosomal RNA and translation. Annu. Rev. Biochem. 60:191-227.
21. Ogle, J. M., D. E. Brodersen, W. M. Clemons Jr., M. J. Tarry, A. P. Carter, and V. Ramakrishnan. 2001. Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science 292:897-902.
22. Pardo, J. M., F. Malpartida, M. Rico, and A. Jimenez. 1985. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism. J. Gen. Microbiol. 131:1289-1298.
23. Prammananan, T., P. Sander, B. A. Brown, K. Frischkorn, G. O. Onyi, Y. Zhang, E. C. Böttger, and R. J. Wallace. 1998. A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae. J. Infect. Dis. 177:1573-1581.
24. mut strains. Antimicrob. Agents Chemother. 43:447-453.
25. Rao, R. N., N. E. Allen, J. N. Hobbs, Jr., W. E. Alborn, Jr., H. A. Kirst, and J. W. Paschall. 1983. Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli. Antimicrob. Agents Chemother. 24:689-695.
26. Recht, M. I., S. Douthwaite, and J. D. Puglisi. 1999. Basis for prokaryotic specificity of action of aminoglycoside antibiotics. EMBO J. 18:3133-3138.
27. nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. +: a dominant selectable marker for gene replacement in mycobacteria. Mol. Microbiol. 16:991-1000.
29. Sander, P., T. Prammananan, and E. C. Böttger. 1996. Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon. Mol. Microbiol. 22:841-848.
30. Sander, P., T. Prammananan, A. Meier, K. Fischkorn, and E. C. Böttger. 1997. The role of ribosomal RNAs in macrolide resistance. Mol. Microbiol. 26:469-480.
31. Schlünzen, F., R. Zarivach, J. Harms, A. Bashan, R. Albrecht, A. Yonath, and F. Franceschi. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413:814-821.
32. Spangler, E. A., and E. H. Blackburn. 1985. The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to antibiotics the paramomycin and hygromycin. J. Biol. Chem. 260:6334-6340.
33. Springer, B., Y. G. Kidan, T. Prammananan, K. Ellrott, E. C. Böttger, and P. Sander. 2001. Mechanisms of streptomycin resistance: forcing drug resistance conferring mutations into the 16S rRNA. Antimicrob. Agents Chemother. 45:2877-2884.
34. Springer, B., P. Sander, L. Sedlacek, K. Ellrott, and E. C. Böttger. 2001. Instability and site-specific excision of intergration-proficient mycobacteriophage L5 plasmids: development of stably maintained integrative vectors. Int. J. Med. Microbiol. 290:669-675.
35. Stover, C. K., V. F. de la Cruz, T. R. Fuerst, J. E. Burlein, L. A. Benson, L. T. Bennett, G. P. Bansal, J. F. Young, M. H. Lee, G. F. Hatfull, S. B. Snapper, R. G. Barletta, W. R. Jacobs, and B. R. Bloom. 1991. New use of BCG for recombinant vaccines. Nature 351:456-460.
36. Umezawa, H., and I. R. Hooper (ed.). 1982. Aminoglycoside antibiotics. Springer-Verlag, New York, N.Y.
37. Vicens, Q., and E. Westhof. 2001. Crystal structure of paramomycin docked into the eubacterial ribosomal decoding A site. Structure 9:647-658.
38. Williams, R. J., and D. L. Heymann. 1998. Containment of antibiotic resistance. Science 279:1153-1154.
39. Zierhut, G., W. Piepersberg, and A. Böck. 1979. Comparative analysis of the effect of aminoglycosides on bacterial protein synthesis in vitro. Eur. J. Biochem. 98:577-583.