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Volumn 41, Issue 11, 2005, Pages 684-693

Cell therapy and other neuroregenerative strategies in Parkinson's disease (II);Terapia celular y otras estrategias neurorregenerativas en la enfermedad de Parkinson (II)

Author keywords

Cell therapy; GDNF; Neuroregeneration; Neurorestoration; Neurotrophic factors; Parkinson's disease; Transplantation

Indexed keywords

CYCLOSPORIN A; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PLACEBO; DOPAMINE; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT;

EID: 33644842451     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.4111.2005276     Document Type: Review
Times cited : (6)

References (104)
  • 1
    • 33644827324 scopus 로고    scopus 로고
    • Terapia celular y otras estrategias neurorregenerativas en la enfermedad de Parkinson (I)
    • Mínguez A, Escamilla F. Terapia celular y otras estrategias neurorregenerativas en la enfermedad de Parkinson (I). Rev Neurol 2005; 41: 604-14.
    • (2005) Rev Neurol , vol.41 , pp. 604-614
    • Mínguez, A.1    Escamilla, F.2
  • 3
    • 0028868574 scopus 로고
    • Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
    • Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nat Med 1995; 11: 1189-94.
    • (1995) Nat Med , vol.11 , pp. 1189-1194
    • Isacson, O.1    Deacon, T.W.2    Pakzaban, P.3    Galpern, W.R.4    Dinsmore, J.5    Burns, L.H.6
  • 4
    • 0030198586 scopus 로고    scopus 로고
    • Xenotransplantation of porcine embryonic ventral mesencephalon in a rat model of Parkinson's disease: Functional recovery and graft morphology
    • Galpern WR, Burns LH, Deacon TW, Dinsmore J, Isacson O. Xenotransplantation of porcine embryonic ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology. Exp Neurol 1996; 140: 1-13.
    • (1996) Exp Neurol , vol.140 , pp. 1-13
    • Galpern, W.R.1    Burns, L.H.2    Deacon, T.W.3    Dinsmore, J.4    Isacson, O.5
  • 5
    • 17544400499 scopus 로고    scopus 로고
    • Transplantation of embryonic porcine mesencephalic tissue in patients with Parkinson's disease
    • Schumacher JM, Ellias SA, Palmer EP, Kott HS, Dinsmore J, Dempsey PK, et al. Transplantation of embryonic porcine mesencephalic tissue in patients with Parkinson's disease. Neurology 2000: 54; 1042-9.
    • (2000) Neurology , vol.54 , pp. 1042-1049
    • Schumacher, J.M.1    Ellias, S.A.2    Palmer, E.P.3    Kott, H.S.4    Dinsmore, J.5    Dempsey, P.K.6
  • 6
    • 16944366484 scopus 로고    scopus 로고
    • Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease
    • Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med 1997; 3: 350-3.
    • (1997) Nat Med , vol.3 , pp. 350-353
    • Deacon, T.1    Schumacher, J.2    Dinsmore, J.3    Thomas, C.4    Palmer, P.5    Kott, S.6
  • 7
    • 0037378740 scopus 로고    scopus 로고
    • Neuroprotection in Parkinson's disease: Clinical trials
    • Stocchi F, Olanow CW. Neuroprotection in Parkinson's disease: clinical trials. Ann Neurol 2003; 53 (Suppl 3): S87-99.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Stocchi, F.1    Olanow, C.W.2
  • 8
    • 0035998724 scopus 로고    scopus 로고
    • Striatal xenotransplantation of human retinal pigment epithelial cells atthached to microcarriers in hemiparkinsonian rats ameliorates behavioural deficits without provoking a host immune response
    • Subramanian T, Marchionini D, Potter EM, Cornfeldt ML. Striatal xenotransplantation of human retinal pigment epithelial cells atthached to microcarriers in hemiparkinsonian rats ameliorates behavioural deficits without provoking a host immune response. Cell Transplant 2002; 11: 207-14.
    • (2002) Cell Transplant , vol.11 , pp. 207-214
    • Subramanian, T.1    Marchionini, D.2    Potter, E.M.3    Cornfeldt, M.L.4
  • 9
    • 0141940594 scopus 로고    scopus 로고
    • Stereotaxic intraestriatal implantation of human retinal pigment epithelial cells attached to gelatine microcarriers: A potential new cell therapy for Parkinson's disease
    • Watts RL, Raiser CD, Stover NP, Cornfeldt ML, Schweikert AW, Allen RC, et al. Stereotaxic intraestriatal implantation of human retinal pigment epithelial cells attached to gelatine microcarriers: a potential new cell therapy for Parkinson's disease. J Neural Transm Suppl 2003; 65: 215-27.
    • (2003) J Neural Transm Suppl , vol.65 , pp. 215-227
    • Watts, R.L.1    Raiser, C.D.2    Stover, N.P.3    Cornfeldt, M.L.4    Schweikert, A.W.5    Allen, R.C.6
  • 10
    • 0023783451 scopus 로고    scopus 로고
    • 2 in type I chemoreceptor cells. Science 1988; 241: 580-2.
    • 2 in type I chemoreceptor cells. Science 1988; 241: 580-2.
  • 12
    • 0024156714 scopus 로고
    • Comparison of adrenal medullary, carotid body and PC12 cell grafts in 6-OHDA lesioned rats
    • Bing GY, Notter MF, Hansen JT, Gash DM. Comparison of adrenal medullary, carotid body and PC12 cell grafts in 6-OHDA lesioned rats. Brain Res Bull 1988; 20: 399-406.
    • (1988) Brain Res Bull , vol.20 , pp. 399-406
    • Bing, G.Y.1    Notter, M.F.2    Hansen, J.T.3    Gash, D.M.4
  • 13
    • 0032005461 scopus 로고    scopus 로고
    • Cellular and functional recovery of parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates
    • Espejo E, Montoro RJ, Armengol JA, López-Barneo J. Cellular and functional recovery of parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron 1998; 20: 197-206.
    • (1998) Neuron , vol.20 , pp. 197-206
    • Espejo, E.1    Montoro, R.J.2    Armengol, J.A.3    López-Barneo, J.4
  • 14
    • 0036097063 scopus 로고    scopus 로고
    • Dopaminergic cells of the carotid body: Physiological significance and possible therapeutic applications in Parkinson's disease
    • Toledo-Aral JJ, Méndez-Ferrer S, Pardal R, López-Barneo J. Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease. Brain Res Bull 2002; 57: 847-53.
    • (2002) Brain Res Bull , vol.57 , pp. 847-853
    • Toledo-Aral, J.J.1    Méndez-Ferrer, S.2    Pardal, R.3    López-Barneo, J.4
  • 15
    • 0037221429 scopus 로고    scopus 로고
    • Throfic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body grafted parkinsonian rats
    • Toledo-Aral JJ, Méndez-Ferrer S, Pardal R, Echevarría M, López-Barneo J. Throfic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body grafted parkinsonian rats. J Neurosci 2003; 23: 141-8.
    • (2003) J Neurosci , vol.23 , pp. 141-148
    • Toledo-Aral, J.J.1    Méndez-Ferrer, S.2    Pardal, R.3    Echevarría, M.4    López-Barneo, J.5
  • 16
    • 0021751184 scopus 로고
    • A morphometric study of the carotid body in chronically hypoxic rats
    • McGregor KH, Gil J, Lahiri S. A morphometric study of the carotid body in chronically hypoxic rats. J Appl Physiol 1984; 57: 1430-8.
    • (1984) J Appl Physiol , vol.57 , pp. 1430-1438
    • McGregor, K.H.1    Gil, J.2    Lahiri, S.3
  • 17
    • 0026577610 scopus 로고
    • Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia
    • Czyzyk-Krzeska MF, Bayliss DA, Lawson EE, Millhorn DE. Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia. J Neurochem 1992; 58: 1538-56.
    • (1992) J Neurochem , vol.58 , pp. 1538-1556
    • Czyzyk-Krzeska, M.F.1    Bayliss, D.A.2    Lawson, E.E.3    Millhorn, D.E.4
  • 18
    • 0029801527 scopus 로고    scopus 로고
    • Cellular expression of GDNF mRNA suggest multiple functions inside and outside the nervous system
    • Nosrat CA, Tomac A, Lindqvist E, Lindskog S, Humpel C, Stromberg I, et al. Cellular expression of GDNF mRNA suggest multiple functions inside and outside the nervous system. Cell Tissue Res 1996; 286: 191-207.
    • (1996) Cell Tissue Res , vol.286 , pp. 191-207
    • Nosrat, C.A.1    Tomac, A.2    Lindqvist, E.3    Lindskog, S.4    Humpel, C.5    Stromberg, I.6
  • 20
    • 17644392790 scopus 로고    scopus 로고
    • Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation
    • Villadiego J, Méndez-Ferrer S, Valdés-Sánchez T, Silos-Santiago I, Fariñas I, López-Barneo J, et al. Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J Neurosci 2005 25: 4091-8.
    • (2005) J Neurosci , vol.25 , pp. 4091-4098
    • Villadiego, J.1    Méndez-Ferrer, S.2    Valdés-Sánchez, T.3    Silos-Santiago, I.4    Fariñas, I.5    López-Barneo, J.6
  • 21
    • 0026653917 scopus 로고
    • Respiratory and circulatory activities in carotid body ressected humans
    • Honda Y. Respiratory and circulatory activities in carotid body ressected humans. J Appl Physiol 1992; 73: 1-8.
    • (1992) J Appl Physiol , vol.73 , pp. 1-8
    • Honda, Y.1
  • 22
    • 0342308802 scopus 로고    scopus 로고
    • Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen
    • Luquin MR, Montoro RJ, Guillen J, Saldise L, Insausti R, Del Río J, et al. Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron 1999; 22: 743-50.
    • (1999) Neuron , vol.22 , pp. 743-750
    • Luquin, M.R.1    Montoro, R.J.2    Guillen, J.3    Saldise, L.4    Insausti, R.5    Del Río, J.6
  • 23
    • 0036955707 scopus 로고    scopus 로고
    • Intraestriatal grafting of glomus cells ameliorates behavioural defects of parkinsonian rats
    • Hao G, Yao Y, Wang J, Zhang L, Viroonchatapan N, Wang ZZ. Intraestriatal grafting of glomus cells ameliorates behavioural defects of parkinsonian rats. Physiol Behav 2002; 77: 519-25.
    • (2002) Physiol Behav , vol.77 , pp. 519-525
    • Hao, G.1    Yao, Y.2    Wang, J.3    Zhang, L.4    Viroonchatapan, N.5    Wang, Z.Z.6
  • 24
    • 5444276658 scopus 로고    scopus 로고
    • Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine- lesioned rats: Implications for Parkinson's disease
    • Shukla S, Agrawal AK, Chaturvedi RK, Seth K, Srivastava N, Sinha C, et al. Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine- lesioned rats: implications for Parkinson's disease. J Neurochem 2004; 91: 274-84.
    • (2004) J Neurochem , vol.91 , pp. 274-284
    • Shukla, S.1    Agrawal, A.K.2    Chaturvedi, R.K.3    Seth, K.4    Srivastava, N.5    Sinha, C.6
  • 26
    • 34548017112 scopus 로고    scopus 로고
    • Mínguez-Castellanos A. Trasplante de agregados celulares del cuerpo carotídeo en pacientes con enfermedad de Parkinson [tesis doctoral]. Granada: Universidad de Granada; 2005.
    • Mínguez-Castellanos A. Trasplante de agregados celulares del cuerpo carotídeo en pacientes con enfermedad de Parkinson [tesis doctoral]. Granada: Universidad de Granada; 2005.
  • 27
    • 34548019893 scopus 로고    scopus 로고
    • Grupo de Trasplantes Neurales de la Clínica Puerta de Hierro. Trasplantes neurales en la enfermedad de Parkinson: Experiencia de la Clínica Puerta de Hierro y estado actual
    • López-Lozano JJ, Mata M, Bravo G, Grupo de Trasplantes Neurales de la Clínica Puerta de Hierro. Trasplantes neurales en la enfermedad de Parkinson: experiencia de la Clínica Puerta de Hierro y estado actual. Neurología 2000; 15 (Supl 5): 62-79.
    • (2000) Neurología , vol.15 , Issue.SUPL 5 , pp. 62-79
    • López-Lozano, J.J.1    Mata, M.2    Bravo, G.3
  • 28
    • 0025020959 scopus 로고
    • Autolo gous transplantation of the superior cervical ganglion into the brain of parkinsonian monkeys
    • Nakai M, Itakura T, Kamei I, Nakai K, Naka Y, Imai H, et al. Autolo gous transplantation of the superior cervical ganglion into the brain of parkinsonian monkeys. J Neurosurg 1990; 72: 91-5.
    • (1990) J Neurosurg , vol.72 , pp. 91-95
    • Nakai, M.1    Itakura, T.2    Kamei, I.3    Nakai, K.4    Naka, Y.5    Imai, H.6
  • 29
    • 0031392319 scopus 로고    scopus 로고
    • Transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease: Long-term follow-up of 35 cases
    • Itakura T, Uematsu Y, Nakao N, Nakai E, Nakai K. Transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease: long-term follow-up of 35 cases. Stereotact Funct Neurosurg 1997; 69: 112-5.
    • (1997) Stereotact Funct Neurosurg , vol.69 , pp. 112-115
    • Itakura, T.1    Uematsu, Y.2    Nakao, N.3    Nakai, E.4    Nakai, K.5
  • 30
    • 0025310035 scopus 로고
    • Autotransplantation of superior cervical ganglion to the caudate nucleus in three patients with Parkinson's disease (preliminary report)
    • Hovarth M, Pasztor E, Palkovits M, Solyom A, Tarczy M, Lekka N, et al. Autotransplantation of superior cervical ganglion to the caudate nucleus in three patients with Parkinson's disease (preliminary report). Neuorosurg Rev 1990; 13: 119-22.
    • (1990) Neuorosurg Rev , vol.13 , pp. 119-122
    • Hovarth, M.1    Pasztor, E.2    Palkovits, M.3    Solyom, A.4    Tarczy, M.5    Lekka, N.6
  • 31
    • 0034872738 scopus 로고    scopus 로고
    • Enhancement of the response to levodopa therapy after intrastriatal transplantation of autologous sympathetic neurons in patients with Parkinson disease
    • Nakao N, Kakishita K, Uematsu Y, Yoshimasu T, Bessho T, Nakai K, et al. Enhancement of the response to levodopa therapy after intrastriatal transplantation of autologous sympathetic neurons in patients with Parkinson disease. J Neurosurg 2001; 95: 275-84.
    • (2001) J Neurosurg , vol.95 , pp. 275-284
    • Nakao, N.1    Kakishita, K.2    Uematsu, Y.3    Yoshimasu, T.4    Bessho, T.5    Nakai, K.6
  • 32
    • 2942513693 scopus 로고    scopus 로고
    • The ability of grafted human sympathetic neurons to synthesize and store dopamine: A potential mechanism for the clinical effect of sympathetic neuron autografts in patients with Parkinson's disease
    • Nakao N, Shintani-Mizushima A, Kakishita K, Itakura T. The ability of grafted human sympathetic neurons to synthesize and store dopamine: a potential mechanism for the clinical effect of sympathetic neuron autografts in patients with Parkinson's disease. Exp Neurol 2004; 188: 65-73.
    • (2004) Exp Neurol , vol.188 , pp. 65-73
    • Nakao, N.1    Shintani-Mizushima, A.2    Kakishita, K.3    Itakura, T.4
  • 34
    • 0031265954 scopus 로고    scopus 로고
    • Intracerebral transplantation of testis-derived Sertoli cells promotes functional reocovery in female reats with 6-hidroxydopamine-induced hemiparkinsonism
    • Borlongan CV, Cameron DF, Saporta S, Sanberg PR. Intracerebral transplantation of testis-derived Sertoli cells promotes functional reocovery in female reats with 6-hidroxydopamine-induced hemiparkinsonism. Exp Neurol 1997; 148: 388-99.
    • (1997) Exp Neurol , vol.148 , pp. 388-399
    • Borlongan, C.V.1    Cameron, D.F.2    Saporta, S.3    Sanberg, P.R.4
  • 35
    • 0033554227 scopus 로고    scopus 로고
    • Intrastriatal transplantation of Sertoli cells may improve amphetamine-induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats
    • Liu HW, Kuang YJ, Wu JC, Ma KH, Wang SD, Liu JC. Intrastriatal transplantation of Sertoli cells may improve amphetamine-induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats. Brain Res 1999; 838: 22-233.
    • (1999) Brain Res , vol.838 , pp. 22-233
    • Liu, H.W.1    Kuang, Y.J.2    Wu, J.C.3    Ma, K.H.4    Wang, S.D.5    Liu, J.C.6
  • 36
    • 0031918809 scopus 로고    scopus 로고
    • Trophic effect of porcine Sertoli cells on rat and human ventral mesencephalic cells and hNT neurons in vitro
    • Othberg AI, Willing AE, Cameron DF, Anton A, Saporta S, Freeman TB, et al. Trophic effect of porcine Sertoli cells on rat and human ventral mesencephalic cells and hNT neurons in vitro. Cell Transplant 1998; 7: 157-64.
    • (1998) Cell Transplant , vol.7 , pp. 157-164
    • Othberg, A.I.1    Willing, A.E.2    Cameron, D.F.3    Anton, A.4    Saporta, S.5    Freeman, T.B.6
  • 37
    • 0030762745 scopus 로고    scopus 로고
    • Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats
    • Sanberg PR, Borlongan CV, Othberg AI, Saporta S, Freeman TB, Cameron DF. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Nat Med 1997; 3: 1129-32.
    • (1997) Nat Med , vol.3 , pp. 1129-1132
    • Sanberg, P.R.1    Borlongan, C.V.2    Othberg, A.I.3    Saporta, S.4    Freeman, T.B.5    Cameron, D.F.6
  • 38
    • 12644289287 scopus 로고    scopus 로고
    • Polymer-encapsulated PC-12 cells demonstrate highaffinity uptake of dopamine in vitro and 18F-dopa uptake and metabolism after intracerebral implantation in nonhuman primates
    • Subramanian T, Emerich DF, Bakay RA, Hoffman JM, Goodman MM, Shoup TM, et al. Polymer-encapsulated PC-12 cells demonstrate highaffinity uptake of dopamine in vitro and 18F-dopa uptake and metabolism after intracerebral implantation in nonhuman primates. Cell Transplant 1997; 6: 469-77.
    • (1997) Cell Transplant , vol.6 , pp. 469-477
    • Subramanian, T.1    Emerich, D.F.2    Bakay, R.A.3    Hoffman, J.M.4    Goodman, M.M.5    Shoup, T.M.6
  • 39
    • 0034533051 scopus 로고    scopus 로고
    • Grafting of encapsulated dopamine-secreting cells in Parkinson's disease: Long-term primate study
    • Date I, Shingo T, Yoshida H, Fujiwara K, Kobayashi K, Ohmoto T. Grafting of encapsulated dopamine-secreting cells in Parkinson's disease: long-term primate study. Cell Transplant 2000; 9: 705-9.
    • (2000) Cell Transplant , vol.9 , pp. 705-709
    • Date, I.1    Shingo, T.2    Yoshida, H.3    Fujiwara, K.4    Kobayashi, K.5    Ohmoto, T.6
  • 40
    • 0037385053 scopus 로고    scopus 로고
    • Stereotactic transplantation of a dopamine-producing capsule into the striatum for treatment of Parkinson disease: A preclinical primate study
    • Yoshida H, Date I, Shingo T, Fujiwara K, Kobayashi K, Miyoshi Y, et al. Stereotactic transplantation of a dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study. J Neurosurg 2003; 98: 874-81.
    • (2003) J Neurosurg , vol.98 , pp. 874-881
    • Yoshida, H.1    Date, I.2    Shingo, T.3    Fujiwara, K.4    Kobayashi, K.5    Miyoshi, Y.6
  • 41
    • 0030006065 scopus 로고    scopus 로고
    • Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts
    • Bencsics C, Wachtel SR, Milstien S, Hatakeyama K, Becker JB, Kang UJ. Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. J Neurosci 1996;16: 4449-56.
    • (1996) J Neurosci , vol.16 , pp. 4449-4456
    • Bencsics, C.1    Wachtel, S.R.2    Milstien, S.3    Hatakeyama, K.4    Becker, J.B.5    Kang, U.J.6
  • 42
    • 0032102936 scopus 로고    scopus 로고
    • In vivo LDOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase
    • Leff SE, Rendahl KG, Spratt SK, Kang UJ, Mandel RJ. In vivo LDOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. Exp Neurol 1998; 151: 249-64.
    • (1998) Exp Neurol , vol.151 , pp. 249-264
    • Leff, S.E.1    Rendahl, K.G.2    Spratt, S.K.3    Kang, U.J.4    Mandel, R.J.5
  • 43
    • 0042123935 scopus 로고    scopus 로고
    • Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes
    • Chen S, Xianwen C, Dehua X, Zhenguo L, Lingfei X, Smith SW, et al. Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes. Parkinsonism Relat Disord 2003; 9 (Suppl 2): S91-7.
    • (2003) Parkinsonism Relat Disord , vol.9 , Issue.SUPPL. 2
    • Chen, S.1    Xianwen, C.2    Dehua, X.3    Zhenguo, L.4    Lingfei, X.5    Smith, S.W.6
  • 44
    • 0028276809 scopus 로고
    • Implanted fibroblasts genetically engineered to produce brainderived neurotrophic factor prevent MPTP toxicity to dopaminergic neurons in the rat
    • Frim DM, Uhler TA, Galpern WR, Beal MF, Breakefield XO, Isacson O. Implanted fibroblasts genetically engineered to produce brainderived neurotrophic factor prevent MPTP toxicity to dopaminergic neurons in the rat. Proc Natl Acad Sci USA 1994; 91: 5104-8.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5104-5108
    • Frim, D.M.1    Uhler, T.A.2    Galpern, W.R.3    Beal, M.F.4    Breakefield, X.O.5    Isacson, O.6
  • 45
    • 0029610630 scopus 로고
    • Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
    • Levivier M, Przedborski S, Bencsics C, Kang UJ. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 1995; 15: 7810-20.
    • (1995) J Neurosci , vol.15 , pp. 7810-7820
    • Levivier, M.1    Przedborski, S.2    Bencsics, C.3    Kang, U.J.4
  • 46
    • 15044349743 scopus 로고    scopus 로고
    • Long-term restoration of nigrostriatal system function by implanting GDNF genetically modified fibroblasts in a rat model of Parkinson's disease
    • Duan D, Yang H, Zhang J, Zhang J, Xu Q. Long-term restoration of nigrostriatal system function by implanting GDNF genetically modified fibroblasts in a rat model of Parkinson's disease. Exp Brain Res 2005; 161: 316-24.
    • (2005) Exp Brain Res , vol.161 , pp. 316-324
    • Duan, D.1    Yang, H.2    Zhang, J.3    Zhang, J.4    Xu, Q.5
  • 47
    • 0033959027 scopus 로고    scopus 로고
    • Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioral recovery in experimental parkinsonism
    • Cortez N, Trejo F, Vergara P, Segovia J. Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioral recovery in experimental parkinsonism. J Neurosci Res 2000; 59: 39-46.
    • (2000) J Neurosci Res , vol.59 , pp. 39-46
    • Cortez, N.1    Trejo, F.2    Vergara, P.3    Segovia, J.4
  • 48
    • 0032722089 scopus 로고    scopus 로고
    • Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: In vitro study and transplantation to hemiparkinsonian model rats
    • Hida H, Hashimoto M, Fujimoto I, Nakajima K, Shimano Y, Nagatsu T, et al. Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats. Neurosci Res 1999; 35: 101-12.
    • (1999) Neurosci Res , vol.35 , pp. 101-112
    • Hida, H.1    Hashimoto, M.2    Fujimoto, I.3    Nakajima, K.4    Shimano, Y.5    Nagatsu, T.6
  • 49
    • 0034895752 scopus 로고    scopus 로고
    • Protection of nigral neurons by GDNF-engineered marrow cell transplantation
    • Park KW, Eglitis MA, Mouradian MM. Protection of nigral neurons by GDNF-engineered marrow cell transplantation. Neurosci Res 2001; 40: 315-23.
    • (2001) Neurosci Res , vol.40 , pp. 315-323
    • Park, K.W.1    Eglitis, M.A.2    Mouradian, M.M.3
  • 50
    • 0029981428 scopus 로고    scopus 로고
    • Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene
    • Hoshimaru M, Ray J, Sah DW, Gage FH. Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proc Natl Acad Sci USA 1996; 93: 1518-23.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1518-1523
    • Hoshimaru, M.1    Ray, J.2    Sah, D.W.3    Gage, F.H.4
  • 51
    • 0034109787 scopus 로고    scopus 로고
    • Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor
    • Nakao N, Yokote H, Nakai K, Itakura T. Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor. J Neurosurg 2000; 92: 659-70.
    • (2000) J Neurosurg , vol.92 , pp. 659-670
    • Nakao, N.1    Yokote, H.2    Nakai, K.3    Itakura, T.4
  • 52
    • 13844280470 scopus 로고    scopus 로고
    • Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease
    • Yasuhara T, Shingo T, Muraoka K, Kobayashi K, Takeuchi A, Yano A, et al. Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease. J Neurosurg 2005; 102: 80-9.
    • (2005) J Neurosurg , vol.102 , pp. 80-89
    • Yasuhara, T.1    Shingo, T.2    Muraoka, K.3    Kobayashi, K.4    Takeuchi, A.5    Yano, A.6
  • 53
    • 0032980340 scopus 로고    scopus 로고
    • Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes
    • Wagner J, Akerud P, Castro DS, Holm PC, Canals JM, Snyder EY, et al. Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes. Nat Biotechnol 1999; 17: 653-9.
    • (1999) Nat Biotechnol , vol.17 , pp. 653-659
    • Wagner, J.1    Akerud, P.2    Castro, D.S.3    Holm, P.C.4    Canals, J.M.5    Snyder, E.Y.6
  • 54
    • 0035887595 scopus 로고    scopus 로고
    • Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    • Akerud P, Canals JM, Snyder EY, Arenas E. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. J Neurosci 2001; 21: 8108-18.
    • (2001) J Neurosci , vol.21 , pp. 8108-8118
    • Akerud, P.1    Canals, J.M.2    Snyder, E.Y.3    Arenas, E.4
  • 55
    • 0031936039 scopus 로고    scopus 로고
    • Blastuladerived stem cells can differentiate into dopaminergic and serotoninergic neurons after transplantation
    • Deacon T, Dinsmore J, Costantini LC, Ratliff J, Isacson O. Blastuladerived stem cells can differentiate into dopaminergic and serotoninergic neurons after transplantation. Exp Neurol 1998; 149: 28-41.
    • (1998) Exp Neurol , vol.149 , pp. 28-41
    • Deacon, T.1    Dinsmore, J.2    Costantini, L.C.3    Ratliff, J.4    Isacson, O.5
  • 57
    • 0036096908 scopus 로고    scopus 로고
    • Stem cells in the treatment of Parkinson's disease
    • Arenas E. Stem cells in the treatment of Parkinson's disease. Brain Res Bull 2002; 57: 795-808.
    • (2002) Brain Res Bull , vol.57 , pp. 795-808
    • Arenas, E.1
  • 58
    • 0037019332 scopus 로고    scopus 로고
    • Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    • Kim JH, Auerbach JM, Rodríguez-Gómez JA, Velasco I, Gavin D, Lumelsky N, et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002; 418: 50-6.
    • (2002) Nature , vol.418 , pp. 50-56
    • Kim, J.H.1    Auerbach, J.M.2    Rodríguez-Gómez, J.A.3    Velasco, I.4    Gavin, D.5    Lumelsky, N.6
  • 59
    • 0037022299 scopus 로고    scopus 로고
    • Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
    • Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, et al. Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci USA 2002; 99: 1580-5.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1580-1585
    • Kawasaki, H.1    Suemori, H.2    Mizuseki, K.3    Watanabe, K.4    Urano, F.5    Ichinose, H.6
  • 60
    • 85047689727 scopus 로고    scopus 로고
    • Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
    • Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest 2005; 115: 102-9.
    • (2005) J Clin Invest , vol.115 , pp. 102-109
    • Takagi, Y.1    Takahashi, J.2    Saiki, H.3    Morizane, A.4    Hayashi, T.5    Kishi, Y.6
  • 61
    • 0035957754 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer
    • Wakayama T, Tabar V, Rodríguez I, Perry AC, Studer L, Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 2001; 292: 740-3.
    • (2001) Science , vol.292 , pp. 740-743
    • Wakayama, T.1    Tabar, V.2    Rodríguez, I.3    Perry, A.C.4    Studer, L.5    Mombaerts, P.6
  • 62
    • 10744229091 scopus 로고    scopus 로고
    • Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    • Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, et al. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 2003; 21: 1200-7.
    • (2003) Nat Biotechnol , vol.21 , pp. 1200-1207
    • Barberi, T.1    Klivenyi, P.2    Calingasan, N.Y.3    Lee, H.4    Kawamata, H.5    Loonam, K.6
  • 63
    • 33644684826 scopus 로고    scopus 로고
    • Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats
    • Studer L, Tabar V, McKay RDG. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat Neurosci 1998; 1: 290-5.
    • (1998) Nat Neurosci , vol.1 , pp. 290-295
    • Studer, L.1    Tabar, V.2    McKay, R.D.G.3
  • 64
    • 0034845508 scopus 로고    scopus 로고
    • A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: A source of cells for transplantation in Parkinson's disease
    • Carvey PM, Ling ZD, Sortwell CE, Pitzer MR, McGuire SO, Storch A, et al. A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease. Exp Neurol 2001; 171: 98-108.
    • (2001) Exp Neurol , vol.171 , pp. 98-108
    • Carvey, P.M.1    Ling, Z.D.2    Sortwell, C.E.3    Pitzer, M.R.4    McGuire, S.O.5    Storch, A.6
  • 65
    • 0034871846 scopus 로고    scopus 로고
    • Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    • Storch A, Paul G, Csete M, Boehm BO, Carvey PM, Kupsh A, et al. Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Exp Neurol 2001; 170: 317-25.
    • (2001) Exp Neurol , vol.170 , pp. 317-325
    • Storch, A.1    Paul, G.2    Csete, M.3    Boehm, B.O.4    Carvey, P.M.5    Kupsh, A.6
  • 68
    • 11144355842 scopus 로고    scopus 로고
    • Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors?
    • Walczak P, Chen N, Hudson JE, Willing AE, Garbuzova-Davis SN, Song S, et al. Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors? J Neurosci Res 2004; 76: 244-54.
    • (2004) J Neurosci Res , vol.76 , pp. 244-254
    • Walczak, P.1    Chen, N.2    Hudson, J.E.3    Willing, A.E.4    Garbuzova-Davis, S.N.5    Song, S.6
  • 69
    • 0037183884 scopus 로고    scopus 로고
    • Little evidence for developmental plasticity of adult hematopoietic stem cells
    • Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297: 2256-9.
    • (2002) Science , vol.297 , pp. 2256-2259
    • Wagers, A.J.1    Sherwood, R.I.2    Christensen, J.L.3    Weissman, I.L.4
  • 70
    • 0035909960 scopus 로고    scopus 로고
    • Li Y, Chen J, Wang L, Zhang L, Lu M, Chopp M. Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine mouse model of Parkinson's disease. Neurosci Lett 2001; 316: 67-70.
    • Li Y, Chen J, Wang L, Zhang L, Lu M, Chopp M. Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine mouse model of Parkinson's disease. Neurosci Lett 2001; 316: 67-70.
  • 71
    • 0035998728 scopus 로고    scopus 로고
    • Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain
    • Zigova T, Song S, Willing AE, Hudson JE, Newman MB, Saporta S, et al. Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell Transplant 2002; 11: 265-74.
    • (2002) Cell Transplant , vol.11 , pp. 265-274
    • Zigova, T.1    Song, S.2    Willing, A.E.3    Hudson, J.E.4    Newman, M.B.5    Saporta, S.6
  • 73
    • 1242341960 scopus 로고    scopus 로고
    • Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
    • Maslov AY, Barone TA, Plunkett RJ, Pruitt SC. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 2004; 24: 1726-33.
    • (2004) J Neurosci , vol.24 , pp. 1726-1733
    • Maslov, A.Y.1    Barone, T.A.2    Plunkett, R.J.3    Pruitt, S.C.4
  • 75
    • 0036094144 scopus 로고    scopus 로고
    • Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies
    • Lim DA, Flames N, Collado L, Herrera DG. Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies. Brain Res Bull 2002; 57: 759-64.
    • (2002) Brain Res Bull , vol.57 , pp. 759-764
    • Lim, D.A.1    Flames, N.2    Collado, L.3    Herrera, D.G.4
  • 76
    • 0036469278 scopus 로고    scopus 로고
    • Adult neurogenesis in mammals: An identity crisis
    • Rakic P. Adult neurogenesis in mammals: an identity crisis. J Neurosci 2002; 22: 614-8.
    • (2002) J Neurosci , vol.22 , pp. 614-618
    • Rakic, P.1
  • 77
    • 17144469657 scopus 로고    scopus 로고
    • Factores neurotróficos: Fundamentos para su aplicación clínica
    • Moris G, Vega JA. Factores neurotróficos: fundamentos para su aplicación clínica. Neurología 2003; 18: 18-28.
    • (2003) Neurología , vol.18 , pp. 18-28
    • Moris, G.1    Vega, J.A.2
  • 78
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993; 260: 1130-2.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 79
    • 0028109526 scopus 로고
    • Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
    • Hoffer BJ, Hoffman A, Bowenkamp K, Huettl P, Hudson J, Martin D, et al. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 1994; 182: 107-11.
    • (1994) Neurosci Lett , vol.182 , pp. 107-111
    • Hoffer, B.J.1    Hoffman, A.2    Bowenkamp, K.3    Huettl, P.4    Hudson, J.5    Martin, D.6
  • 80
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A, Lindqvist E, Lin LF, Ogren SO, Young D, Hoffer BJ, et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 1995; 373: 335-9.
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.3    Ogren, S.O.4    Young, D.5    Hoffer, B.J.6
  • 81
    • 0029803454 scopus 로고    scopus 로고
    • Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
    • Winkler C, Sauer H, Lee CS, Bjorklund A. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 1996; 16: 7206-15.
    • (1996) J Neurosci , vol.16 , pp. 7206-7215
    • Winkler, C.1    Sauer, H.2    Lee, C.S.3    Bjorklund, A.4
  • 82
    • 13344277993 scopus 로고    scopus 로고
    • Functional recovery in parkinsonian monkeys treated with GDNF
    • Gash DM, Zhang Z, Ovadia A, Cass WA, Yi A, Simmerman L, et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996; 380: 252-5.
    • (1996) Nature , vol.380 , pp. 252-255
    • Gash, D.M.1    Zhang, Z.2    Ovadia, A.3    Cass, W.A.4    Yi, A.5    Simmerman, L.6
  • 83
    • 0034959811 scopus 로고    scopus 로고
    • Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain
    • Chauhan NB, Siegel GJ, Lee JM. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J Chem Neuroanat 2001; 21: 277-88.
    • (2001) J Chem Neuroanat , vol.21 , pp. 277-288
    • Chauhan, N.B.1    Siegel, G.J.2    Lee, J.M.3
  • 84
    • 0036787532 scopus 로고    scopus 로고
    • Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
    • Grondin R, Zhang Z, Yi A, Cass WA, Maswood N, Andersen AH, et al. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain 2002; 125: 2191-201.
    • (2002) Brain , vol.125 , pp. 2191-2201
    • Grondin, R.1    Zhang, Z.2    Yi, A.3    Cass, W.A.4    Maswood, N.5    Andersen, A.H.6
  • 85
    • 0036788442 scopus 로고    scopus 로고
    • GDNF treatment in Parkinson's disease: Time for controlled clinical trials?
    • Brundin P. GDNF treatment in Parkinson's disease: time for controlled clinical trials? Brain 2002; 125: 2149-51.
    • (2002) Brain , vol.125 , pp. 2149-2151
    • Brundin, P.1
  • 86
    • 0037435511 scopus 로고    scopus 로고
    • Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER, et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 2003; 60: 69-73.
    • (2003) Neurology , vol.60 , pp. 69-73
    • Nutt, J.G.1    Burchiel, K.J.2    Comella, C.L.3    Jankovic, J.4    Lang, A.E.5    Laws, E.R.6
  • 87
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in Parkinson's disease
    • Kordower JH, Palfi SP, Chen EY, Ma SY, Sendera T, Cochran EJ, et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in Parkinson's disease. Ann Neurol 1999; 46: 419-24.
    • (1999) Ann Neurol , vol.46 , pp. 419-424
    • Kordower, J.H.1    Palfi, S.P.2    Chen, E.Y.3    Ma, S.Y.4    Sendera, T.5    Cochran, E.J.6
  • 88
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003; 9: 589-95.
    • (2003) Nat Med , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3    O'Sullivan, K.4    McCarter, R.5    Bunnage, M.6
  • 89
    • 0242573187 scopus 로고    scopus 로고
    • Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease
    • Jollivet C, Aubert-Pouessel A, Clavreul A, Venier-Julienne MC, Remy S, Montero-Menei CN, et al. Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease. Biomaterials 2004; 25: 933-42.
    • (2004) Biomaterials , vol.25 , pp. 933-942
    • Jollivet, C.1    Aubert-Pouessel, A.2    Clavreul, A.3    Venier-Julienne, M.C.4    Remy, S.5    Montero-Menei, C.N.6
  • 91
    • 0028559601 scopus 로고
    • Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • During MJ, Naegele JR, O'Malley KL. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 1994; 266: 1399-403.
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    O'Malley, K.L.3
  • 92
    • 0032101756 scopus 로고    scopus 로고
    • Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease
    • Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK, Leff SE. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. J Neurosci 1998; 18: 4271-84.
    • (1998) J Neurosci , vol.18 , pp. 4271-4284
    • Mandel, R.J.1    Rendahl, K.G.2    Spratt, S.K.3    Snyder, R.O.4    Cohen, L.K.5    Leff, S.E.6
  • 93
    • 0034720297 scopus 로고    scopus 로고
    • Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats
    • Leone P, McPhee WJ, Janson CG, Davidson BL, Freese A, During MJ. Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats. Neuroreport 2000; 11: 1145-51.
    • (2000) Neuroreport , vol.11 , pp. 1145-1151
    • Leone, P.1    McPhee, W.J.2    Janson, C.G.3    Davidson, B.L.4    Freese, A.5    During, M.J.6
  • 94
    • 0034691506 scopus 로고    scopus 로고
    • Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease
    • Shen Y, Muramatsu SI, Ikeguchi K, Fujimoto KI, Fan DS, Ogawa M, et al. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Hum Gene Ther 2000; 11: 1509-19.
    • (2000) Hum Gene Ther , vol.11 , pp. 1509-1519
    • Shen, Y.1    Muramatsu, S.I.2    Ikeguchi, K.3    Fujimoto, K.I.4    Fan, D.S.5    Ogawa, M.6
  • 95
    • 0033942230 scopus 로고    scopus 로고
    • Convection-enhanced delivery of AAV vector in parkinsonian monkeys: In vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
    • Bankiewicz KS, Eberling JL, Kohutnicka M, Jagust W, Pivirotto P, Bringas J, et al. Convection-enhanced delivery of AAV vector in parkinsonian monkeys: in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 2000; 164: 2-14.
    • (2000) Exp Neurol , vol.164 , pp. 2-14
    • Bankiewicz, K.S.1    Eberling, J.L.2    Kohutnicka, M.3    Jagust, W.4    Pivirotto, P.5    Bringas, J.6
  • 96
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial-cell- linederived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease
    • Bilang-Bleuel A, Revah F, Colin P, Locquet I, Robert JJ, Mallet J, et al. Intrastriatal injection of an adenoviral vector expressing glial-cell- linederived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci USA 1997; 94: 8818-23.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3    Locquet, I.4    Robert, J.J.5    Mallet, J.6
  • 97
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • Kirik D, Rosenblad C, Bjorklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci 2000; 20: 4686-700.
    • (2000) J Neurosci , vol.20 , pp. 4686-4700
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3    Mandel, R.J.4
  • 98
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 2000; 290: 767-73.
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3    Ma, S.Y.4    Chu, Y.5    Leventhal, L.6
  • 99
    • 0037096359 scopus 로고    scopus 로고
    • Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
    • Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, et al. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci 2002; 22: 4942-54.
    • (2002) J Neurosci , vol.22 , pp. 4942-4954
    • Palfi, S.1    Leventhal, L.2    Chu, Y.3    Ma, S.Y.4    Emborg, M.5    Bakay, R.6
  • 100
    • 0141940624 scopus 로고    scopus 로고
    • Gene therapy for Parkinson's disease
    • Mochizuki H, Mizuno Y. Gene therapy for Parkinson's disease. J Neural Transm Suppl 2003; 65: 205-13.
    • (2003) J Neural Transm Suppl , vol.65 , pp. 205-213
    • Mochizuki, H.1    Mizuno, Y.2
  • 102
    • 0035839562 scopus 로고    scopus 로고
    • Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation
    • During MJ, Kaplitt MG, Stern MB, Eidelberg D. Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum Gene Ther 2001; 12: 1589-91.
    • (2001) Hum Gene Ther , vol.12 , pp. 1589-1591
    • During, M.J.1    Kaplitt, M.G.2    Stern, M.B.3    Eidelberg, D.4
  • 104
    • 0037249449 scopus 로고    scopus 로고
    • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism
    • Zhang Y, Calon F, Zhu C, Boado RJ, Pardridge WM. Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism. Hum Gene Ther 2003; 14: 1-12.
    • (2003) Hum Gene Ther , vol.14 , pp. 1-12
    • Zhang, Y.1    Calon, F.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.