메뉴 건너뛰기




Volumn 36, Issue 11, 2003, Pages 1073-1077

Ex vivo gene therapy in the treatment of Parkinson's disease;Terapia génica ex vivo en el tratamiento de la enfermedad de Parkinson

Author keywords

AADC; GDNF; Gene therapy; GTP cyclohydrolase I; Parkinson's disease; TH; Viral vectors

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 0042306139     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3611.2002262     Document Type: Review
Times cited : (5)

References (30)
  • 1
    • 0034200627 scopus 로고    scopus 로고
    • Parkinson's disease: A neurodegenerative disease particularly amenable to gene therapy
    • Bohn M. Parkinson's disease: a neurodegenerative disease particularly amenable to gene therapy. Mol Ther 2001; 1: 494-6.
    • (2001) Mol Ther , vol.1 , pp. 494-496
    • Bohn, M.1
  • 2
    • 0029928170 scopus 로고    scopus 로고
    • Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF
    • Poduslo JF, Curran GL. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Mol Brain Res 1996; 36: 280-6.
    • (1996) Mol Brain Res , vol.36 , pp. 280-286
    • Poduslo, J.F.1    Curran, G.L.2
  • 3
    • 0343517507 scopus 로고    scopus 로고
    • Lentiviral vectors as a gene delivery system in the mouse midbrain: Cellular and behavioural improvements in a 6-OHDA model of Parkinson's disease using GDNF
    • Bensadoun JC, Déglon N, Tseng JL, Ridet JL, Zurn AD, Aebischer P. Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioural improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp Neurol 2000; 164: 15-24.
    • (2000) Exp Neurol , vol.164 , pp. 15-24
    • Bensadoun, J.C.1    Déglon, N.2    Tseng, J.L.3    Ridet, J.L.4    Zurn, A.D.5    Aebischer, P.6
  • 4
    • 0025833294 scopus 로고
    • Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
    • Renfranz PJ, Cunningham MG, McKay DG. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Cell 1991; 66: 713-29.
    • (1991) Cell , vol.66 , pp. 713-729
    • Renfranz, P.J.1    Cunningham, M.G.2    McKay, D.G.3
  • 5
    • 0029981428 scopus 로고    scopus 로고
    • Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogen
    • Hoshimaru M, Ray J, Sah D, Gage FH. Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogen. Proc Natl Acad Sci 1996; 93: 1518-23.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 1518-1523
    • Hoshimaru, M.1    Ray, J.2    Sah, D.3    Gage, F.H.4
  • 8
    • 0031945063 scopus 로고    scopus 로고
    • Potencial of gene therapy for Parkinson's disease: Neurobiologic issues and new developments in gene transfer methodologies
    • Kang UJ. Potencial of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies. Mov Disord 1998; 13 (Suppl 1): 59-72.
    • (1998) Mov Disord , vol.13 , Issue.SUPPL. 1 , pp. 59-72
    • Kang, U.J.1
  • 9
    • 0030006065 scopus 로고    scopus 로고
    • Double transduction with GTP cyclohydrolase I and Tyrosine hydroxylase is necessary for spontaneous synthesis of L-Dopa by primary fibroblasts
    • Bencsics C, Wachtel SR, Milstien S, Hatakeyama K, Becker JB, Kang UJ. Double transduction with GTP cyclohydrolase I and Tyrosine hydroxylase is necessary for spontaneous synthesis of L-Dopa by primary fibroblasts. J Neurosci 1996; 16: 4449-56.
    • (1996) J Neurosci , vol.16 , pp. 4449-4456
    • Bencsics, C.1    Wachtel, S.R.2    Milstien, S.3    Hatakeyama, K.4    Becker, J.B.5    Kang, U.J.6
  • 10
    • 0029885565 scopus 로고    scopus 로고
    • Central nervous system cell transplantation: A novel therapy for storage diseases?
    • Snyder EY, Wolf JH. Central nervous system cell transplantation: a novel therapy for storage diseases? Curr Opin Neurol 1996; 9: 126-36.
    • (1996) Curr Opin Neurol , vol.9 , pp. 126-136
    • Snyder, E.Y.1    Wolf, J.H.2
  • 11
    • 0033959027 scopus 로고    scopus 로고
    • Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioural recovery in experimental parkisonism
    • Cortez N, Trejo F, Vergara P, Segovia J. Primary astrocytes retrovirally transduced with a tyrosine hydroxylase transgene driven by a glial-specific promoter elicit behavioural recovery in experimental parkisonism. J Neurosci Res 2000; 59: 39-46.
    • (2000) J Neurosci Res , vol.59 , pp. 39-46
    • Cortez, N.1    Trejo, F.2    Vergara, P.3    Segovia, J.4
  • 12
    • 0032416077 scopus 로고    scopus 로고
    • Astrocyte-specific expresion of tyrosine hydroxylase after intracerebral gene transfer induces behavioural recovery in experimental parkisonism
    • Segovia J, Vergara P, Brenner M. Astrocyte-specific expresion of tyrosine hydroxylase after intracerebral gene transfer induces behavioural recovery in experimental parkisonism. Gene Ther 1998; 5: 1650-5.
    • (1998) Gene Ther , vol.5 , pp. 1650-1655
    • Segovia, J.1    Vergara, P.2    Brenner, M.3
  • 14
    • 0034720297 scopus 로고    scopus 로고
    • Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats
    • Leone P, McPhee WJ, Janson CG, Davidson BL, Freese A, During MJ. Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats. Neuroreport 2000; 11: 1145-51.
    • (2000) Neuroreport , vol.11 , pp. 1145-1151
    • Leone, P.1    McPhee, W.J.2    Janson, C.G.3    Davidson, B.L.4    Freese, A.5    During, M.J.6
  • 15
    • 0034981133 scopus 로고    scopus 로고
    • Quantitative analisis of transgene protein, mRNA, and vector DNA following injection of an adenoviral vector harbouring glial cell line-derived neurotrophic factor into the primate caudate nucleus
    • Kozlowski DA, Bremer E, Redmond DE, George D, Larson B, Bohn M. Quantitative analisis of transgene protein, mRNA, and vector DNA following injection of an adenoviral vector harbouring glial cell line-derived neurotrophic factor into the primate caudate nucleus. Mol Ther 2000; 3: 256-61.
    • (2000) Mol Ther , vol.3 , pp. 256-261
    • Kozlowski, D.A.1    Bremer, E.2    Redmond, D.E.3    George, D.4    Larson, B.5    Bohn, M.6
  • 16
    • 0034691506 scopus 로고    scopus 로고
    • Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease
    • Shen Y, Muramatsu SI, Ikeguchi K, Fujimoto KI, Fan DS, Ogawa M, et al. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Hum Gene Ther 2000; 11: 1509-19.
    • (2000) Hum Gene Ther , vol.11 , pp. 1509-1519
    • Shen, Y.1    Muramatsu, S.I.2    Ikeguchi, K.3    Fujimoto, K.I.4    Fan, D.S.5    Ogawa, M.6
  • 17
    • 0034659835 scopus 로고    scopus 로고
    • Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
    • Kirik D, Rosenblad C, Björklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci 2000; 20: 4686-700.
    • (2000) J Neurosci , vol.20 , pp. 4686-4700
    • Kirik, D.1    Rosenblad, C.2    Björklund, A.3    Mandel, R.J.4
  • 18
    • 0028559601 scopus 로고
    • Long-term behavioural recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • During MJ, Naegele JR, O'Malley KL, Geller AI. Long-term behavioural recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 1994; 266: 1399-403.
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    O'Malley, K.L.3    Geller, A.I.4
  • 19
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primates models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primates models of Parkinson's disease. Science 2000; 290: 661-888.
    • (2000) Science , vol.290 , pp. 661-888
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3    Ma, S.Y.4    Chu, Y.5    Leventhal, L.6
  • 20
    • 0032722089 scopus 로고    scopus 로고
    • Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxilase gene: In vitro study and transplantation to hemaparkinsonian model rats
    • Hideki H, Hashimoto M, Fujimoto I, Nakajima K, Shimano Y, Nagatsu T, et al. Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxilase gene: in vitro study and transplantation to hemaparkinsonian model rats. Neurosci Res 1999; 35: 101-12.
    • (1999) Neurosci Res , vol.35 , pp. 101-112
    • Hideki, H.1    Hashimoto, M.2    Fujimoto, I.3    Nakajima, K.4    Shimano, Y.5    Nagatsu, T.6
  • 21
    • 0031897688 scopus 로고    scopus 로고
    • Neuronal death: Is there a role for astrocytes?
    • Tacconi MT. Neuronal death: is there a role for astrocytes? Neurochem Res 1998; 23: 759-65.
    • (1998) Neurochem Res , vol.23 , pp. 759-765
    • Tacconi, M.T.1
  • 22
    • 0032548763 scopus 로고    scopus 로고
    • Differentiation-dependent expression of transgenes in engineered astrocyte cell lines
    • Segovia J, Vergara P, Brenner M. Differentiation-dependent expression of transgenes in engineered astrocyte cell lines. Neurosci Lett 1998; 242: 172-6.
    • (1998) Neurosci Lett , vol.242 , pp. 172-176
    • Segovia, J.1    Vergara, P.2    Brenner, M.3
  • 23
    • 0032101756 scopus 로고    scopus 로고
    • Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease
    • Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK, Leff SE. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. J Neurosci 1998; 18: 4271-84.
    • (1998) J Neurosci , vol.18 , pp. 4271-4284
    • Mandel, R.J.1    Rendahl, K.G.2    Spratt, S.K.3    Snyder, R.O.4    Cohen, L.K.5    Leff, S.E.6
  • 24
    • 0032102936 scopus 로고    scopus 로고
    • In vivo LDOPA production by genetically modified primary rat fibroblast or gliosarcoma cell grafts via coexpression of GTP cyclohydrolase I with tyrosine hydroxylase
    • Leff SE, Rendahl KG, Spratt SK, Kang UJ, Mandel RJ. In vivo LDOPA production by genetically modified primary rat fibroblast or gliosarcoma cell grafts via coexpression of GTP cyclohydrolase I with tyrosine hydroxylase. Exp Neurol 1998; 151: 249-64.
    • (1998) Exp Neurol , vol.151 , pp. 249-264
    • Leff, S.E.1    Rendahl, K.G.2    Spratt, S.K.3    Kang, U.J.4    Mandel, R.J.5
  • 25
    • 0028988127 scopus 로고
    • Aromatic L-amino acid decarboxilase: Biological characterization and functional role
    • Ziiu MY, Jourio AV. Aromatic L-amino acid decarboxilase: biological characterization and functional role. Gen Pharmacol 1995; 26: 681-96.
    • (1995) Gen Pharmacol , vol.26 , pp. 681-696
    • Ziiu, M.Y.1    Jourio, A.V.2
  • 26
    • 0032553713 scopus 로고    scopus 로고
    • Behavioral recovery in 6-OHDA-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vector
    • Fan DS, Ogawa M, Fujimoto KI, Ikeguchi K, Ogasawara Y, Urabe M, et al. Behavioral recovery in 6-OHDA-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vector. Hum Gene Ther 1998; 9: 2527-35.
    • (1998) Hum Gene Ther , vol.9 , pp. 2527-2535
    • Fan, D.S.1    Ogawa, M.2    Fujimoto, K.I.3    Ikeguchi, K.4    Ogasawara, Y.5    Urabe, M.6
  • 27
    • 0033942230 scopus 로고    scopus 로고
    • Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
    • Bankiewicz KS, Eberling JL, Kohutnicka M, Jagust W, Pivirotto P, Bringas J, et al. Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 2000; 164: 2-14.
    • (2000) Exp Neurol , vol.164 , pp. 2-14
    • Bankiewicz, K.S.1    Eberling, J.L.2    Kohutnicka, M.3    Jagust, W.4    Pivirotto, P.5    Bringas, J.6
  • 28
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioural impairment in rat model of Parkinson disease
    • Bilang-Bleuel A, Revah F, Colin P, Locquet I, Robert JJ, Mallet J, et al. Intrastriatal injection of adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioural impairment in rat model of Parkinson disease. Proc Natl Acad Sci 1997; 94: 8818-23.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3    Locquet, I.4    Robert, J.J.5    Mallet, J.6
  • 29
    • 0034895752 scopus 로고    scopus 로고
    • Protection of nigral neurons by GDNF-engineered marrow cell transplantation
    • Park KW, Eglitis MA, Mouradian M. Protection of nigral neurons by GDNF-engineered marrow cell transplantation. Neurosci Res 2001; 40: 315-23.
    • (2001) Neurosci Res , vol.40 , pp. 315-323
    • Park, K.W.1    Eglitis, M.A.2    Mouradian, M.3
  • 30
    • 0034109787 scopus 로고    scopus 로고
    • Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor
    • Nakao N, Yokote H, Nakai K, Itakura T. Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor. J Neurosurg 2000; 92: 659-70.
    • (2000) J Neurosurg , vol.92 , pp. 659-670
    • Nakao, N.1    Yokote, H.2    Nakai, K.3    Itakura, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.