Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: In vitro study and transplantation to hemiparkinsonian model rats

Neuroscience Research

Volumn 35, Issue 2, 1999, Pages 101-112

  Hida, Hideki ^a   Hashimoto, Mitsuhiro ^b   Fujimoto, Ichiro ^c   Nakajima, Keiya ^a   Shimano, Yasunobu ^a   Nagatsu, Toshiharu ^d   Mikoshiba, Katsuhiko ^b,e   Nishino, Hitoo ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d Molecular Genetics Laboratory   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adenoviral vector; Astrocytes; Dopamine; Gene transduction; L dopa; Parkinson's disease; Transplantation; Tyrosine hydroxylase

Indexed keywords

DOPA; TYROSINE 3 MONOOXYGENASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CORPUS STRIATUM; GENE TARGETING; GENETIC TRANSDUCTION; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; TRANSPLANTATION;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; APOMORPHINE; ASTROCYTES; BETA-GALACTOSIDASE; CELLS, CULTURED; CORPUS STRIATUM; DIHYDROXYPHENYLALANINE; FEMALE; GENETIC VECTORS; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; METHAMPHETAMINE; MICE; MICE, INBRED ICR; MUSCULOSKELETAL EQUILIBRIUM; PARKINSON DISEASE; RATS; RATS, WISTAR; SENSATION DISORDERS; TACROLIMUS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

EID: 0032722089     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(99)00073-5     Document Type: Article

References (49)

1. Akli S., Caillaud C., Vigne E. et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3:1993;224-228.
2. Bankiewicz K.S., Leff S.E., Nagy D. et al. Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease. Exp. Neurol. 144(1):1997;147-156.
3. Bencsics C., Wachtel S.R., Milstien S., Hatakeyama K., Becker J.B., Kang U.J. Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. J. Neurosci. 16(14):1996;4449-4456.
4. Björklund A., Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177:1979;555-560.
5. Byrnes A.P., Rusby J.E., Wood M.J.A., Charlton H.M. Adenovirus gene transfer causes inflammation in the brain. Neuroscience. 66(4):1995;1015-1024.
6. Byrnes A.P., MacLaren R.E., Charlton H.M. Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J. Neurosci. 16(9):1996;3045-3055.
7. Castel-Barthe M.N., Jazat-Poindessous F., Barneoud P. et al. Direct intracerebral nerve growth factor gene transfer using a recombinant adenovirus: effect on basal forebrain cholinergic neurons during aging. Neurobiol. Dis. 3:1996;76-86.
8. Chang H., Katoh T., Noda M. et al. Highly efficient adenovirus-mediated gene transfer into renal cells in culture. Kidney Int. 47:1995;322-326.
9. Choi-Lundberg D.L., Lin Q., Chang Y-N. et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science. 275:1997;838-841.
10. Davidson B.L., Allen E.D., Kozarsky K.F., Wilson J.M., Roessler B.J. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat. Genet. 3:1993;219-223.
11. During M.J., Naegele J.R., O'Malley K.L., Geller A.I. Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science. 266:1994;1399-1403.
12. Emerich D.F., Winn S.R., Hantraye P.M. et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature. 386(27):1997;395-399.
13. Fisher L.J., Jinnah H.A., Kale L.C., Higgins G.A., Gage F.H. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-DOPA. Neuron. 6:1991;371-380.
14. Gravel C., Götz R., Lorrain A., Sendtner M. Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nat. Med. 3(7):1997;765-770.
15. Haase G., Kennel P., Pettmann B. et al. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nat. Med. 3(4):1997;429-436.
16. Hashimoto M., Aruga J., Hosoya Y., Kanegae Y., Saito I., Mikoshiba K. A neural cell-type-specific expression system using recombinant adenovirus vectors. Hum. Gene Ther. 7:1996;149-158.
17. Horellou P., Vigne E., Castel M.N. et al. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease. NeuroReport. 6:1994;49-53.
18. Ikenaka K., Nakahira K., Nakajima K. et al. Detection of brain-specific gene expression in brain cells in primary culture: a novel promoter assay based on the use of a retrovirus vector. New Biol. 4:1992;53-60.
19. Isacson O. Behavioral effects and gene delivery in a rat model of Parkinson's disease. Science. 269(11):1995;856.
20. Jiao S., Gurevich V., Wolff J.A. Long-term correction of rat model of Parkinson's disease by gene therapy. Nature. 362:1993;450-453.
21. Juorio A.V., Li X.-M., Walz W., Paterson I.A. Decarboxylation of L-Dopa by cultured mouse astrocytes. Brain Res. 626:1993;306-309.
22. Kanegae Y., Makimura M., Saito I. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn. J. Med. Sci. Biol. 47:1994;157-166.
23. Kanegae Y., Lee G., Sato Y. et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 23:1995;3816-3821.
24. Kaplitt M.G., Leone P., Samulski R.J. et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genet. 8:1994;148-154.
25. Karpati G., Lochmüller H., Nalbantoglu J., Durham H. The principles of gene therapy for the nervous system. Trends Neurosci. 19:1996;49-54.
26. Krougliak V., Graham F.L. Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6:1995;1575-1586.
27. Lapchak P.A., Araujo D.M., Hilt D.C., Sheng J., Jiao S. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Brain Res. 777:1997;153-160.
28. Le Gal La Salle G., Robert J.J., Berrard S. et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science. 259:1993;988-990.
29. Levivier M., Przedborski S., Bencsics C., Kang U.J. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 15(12):1995;7810-7820.
30. Li X.-M., Juorio A.V., Paterson I.A., Walz W., Zhu M.-Y., Boulton A.A. Gene expression of aromatic L-amino acid decarboxylase in cultured rat glial cells. J. Neurochem. 59:1992;1172-1175.
31. Lundberg C., Horellou P., Mallet J., Björklund A. Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson model. Exp. Neurol. 139:1996;39-53.
32. Mandel R.J., Spratt S.K., Snyder R.O., Leff S.E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc. Natl. Acad. Sci. USA. 94:1997;14083-14088.
33. Martínez-Serrano A., Björklund A. Immortalized neural progenitor cells for CNS gene transfer and repair. Trends Neurosci. 20(11):1997;530-538.
34. McCarthy K.D., DeVellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:1980;890-902.
35. Miura M., Tamura T., Mikoshiba K. Cell-specific expression of the mouse glial fibrillary acidic protein gene: Identification of the cis- and trans-acting promoter elements for astrocyte-specific expression. J. Neurochem. 55:1990;1180-1188.
36. Miyake S., Makimura M., Kanegae Y. et al. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA. 93:1996;1320-1324.
37. Nishino H. Intracerebral grafting of catecholamine producing cells and reconstruction of disturbed brain function. Neurosci. Res. 16:1993;157-172.
38. Nishino H., Hashitani T., Kumazaki M. et al. Long-term survival of grafted cells, dopamine synthesis/release, synaptic connections, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-OHDA lesions in the nigrostriatal dopamine pathway. Brain Res. 534:1990;83-93.
39. Pääbo S., Weber F., Kämpe O., Schaffner W., Peterson P.A. Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector. Cell. 35:1983;445-453.
40. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1982;Academic Press, Sydney.
41. Perlow M.J., Freed W.J., Hoffer B.J., Seiger A., Olson L., Wyatt R.J. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science. 204:1979;643-647.
42. Sakai N., Kaufman S., Milstien S. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. J. Neurochem. 65:1995;895-902.
43. Scharfmann R., Axelrod J.H., Verma I.M. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc. Natl. Acad. Sci. USA. 88:1991;4626-4630.
44. Studer L., Tabar V., McKay R.D.G. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat. Neurosci. 1(4):1998;290-295.
45. Takayama H., Ray J., Raymon H.K. et al. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat. Med. 1(1):1995;53-58.
46. Tornatore C., Baker-Cairns B., Yadid G. et al. Expression of tyrosine hydroxylase in an immortalized human fetal astrocyte cell line: in vitro characterization and engraftment into the rodent striatum. Cell Transplant. 5(2):1996;145-163.
47. Ungerstedt U., Arbuthnott G.W. Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. 24:1970;485-493.
48. Wood M.J.A., Charlton H.M., Wood K.J., Kajiwara K., Byrnes A.P. Immune responses to adenovirus vectors in the nervous system. Trends Neurosci. 19(11):1996;497-501.
49. Zhao H., Ivic L., Otaki J.M., Hashimoto M., Mikoshiba K., Firestein S. Functional expression of a mammalian odorant receptor. Science. 279:1998;237-242.