메뉴 건너뛰기




Volumn 16, Issue 22, 1996, Pages 7206-7215

Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease

Author keywords

behavior; GDNF; neurodegeneration; Parkinson's disease; striatum; substantia nigra

Indexed keywords

NEURITE PROMOTING FACTOR;

EID: 0029803454     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-22-07206.1996     Document Type: Article
Times cited : (230)

References (27)
  • 1
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373:339-341.
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck, K.D.1    Valverde, J.2    Alexi, T.3    Poulsen, K.4    Moffat, B.5    Vandlen, R.A.6    Rosenthal, A.7    Hefti, F.8
  • 3
    • 0019465123 scopus 로고
    • Dendritic release of dopamine in the substantia nigra
    • Cheramy A, Leviel V, Glowinski J (1981) Dendritic release of dopamine in the substantia nigra. Nature 289:537-542.
    • (1981) Nature , vol.289 , pp. 537-542
    • Cheramy, A.1    Leviel, V.2    Glowinski, J.3
  • 4
    • 0020987866 scopus 로고
    • Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites
    • Dunnett SB, Björklund A, Schmidt RH, Stenevi U, Iversen SD (1983) Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites. Acta Physiol Scand 522:29-37.
    • (1983) Acta Physiol Scand , vol.522 , pp. 29-37
    • Dunnett, S.B.1    Björklund, A.2    Schmidt, R.H.3    Stenevi, U.4    Iversen, S.D.5
  • 5
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional specificity
    • Fearnley JM, Lees AJ (1991) Ageing and Parkinson's disease: substantia nigra regional specificity. Brain 114:2283-2301.
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 9
    • 0027416834 scopus 로고
    • C-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine neurons in the rat
    • Jenkins R, O'Shea R, Thomas KL, Hunt SP (1993) C-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine neurons in the rat. Neuroscience 53:447-455.
    • (1993) Neuroscience , vol.53 , pp. 447-455
    • Jenkins, R.1    O'Shea, R.2    Thomas, K.L.3    Hunt, S.P.4
  • 10
    • 0028874203 scopus 로고
    • GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
    • Kearns CM, Gash DM (1995) GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res 672:104-111.
    • (1995) Brain Res , vol.672 , pp. 104-111
    • Kearns, C.M.1    Gash, D.M.2
  • 11
    • 0029981267 scopus 로고    scopus 로고
    • Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat
    • Lee CS, Sauer H, Björklund A (1996) Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat. Neuroscience 72:641-653.
    • (1996) Neuroscience , vol.72 , pp. 641-653
    • Lee, C.S.1    Sauer, H.2    Björklund, A.3
  • 12
    • 0027285510 scopus 로고
    • A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty D, Lile J, Bektesh S, Collins F (1993) A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.2    Lile, J.3    Bektesh, S.4    Collins, F.5
  • 13
    • 0025077646 scopus 로고
    • The importance of graft placement and task complexity for transplant-induced recovery of simple and complex sensorimotor deficits in dopamine denervated rats
    • Mandel RJ, Brundin P, Björklund A (1990) The importance of graft placement and task complexity for transplant-induced recovery of simple and complex sensorimotor deficits in dopamine denervated rats. Eur J Neurosci 2:888-894.
    • (1990) Eur J Neurosci , vol.2 , pp. 888-894
    • Mandel, R.J.1    Brundin, P.2    Björklund, A.3
  • 14
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • McGeer PL, Itagaki S, Akiyama H, Mc Geer EG (1988) Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol 24:574-576.
    • (1988) Ann Neurol , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    Mc Geer, E.G.4
  • 15
    • 0028360140 scopus 로고
    • Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model
    • Nikkhah G, Bentlage C, Cunningham MG, Björklund A (1994) Intranigral fetal dopamine grafts induce behavioral compensation in the rat Parkinson model. J Neurosci 14:3449-3461.
    • (1994) J Neurosci , vol.14 , pp. 3449-3461
    • Nikkhah, G.1    Bentlage, C.2    Cunningham, M.G.3    Björklund, A.4
  • 16
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M, Nikkhah G, Bentlage C, Björklund A (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15:3863-3875.
    • (1995) J Neurosci , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Björklund, A.4
  • 19
    • 0017082987 scopus 로고
    • Time course of nigrostriatal degeneration in Parkinson's disease
    • Riederer P, Wuketich S (1976) Time course of nigrostriatal degeneration in Parkinson's disease. J Neural Transm Park Dis Dement Sect 38:277-301.
    • (1976) J Neural Transm Park Dis Dement Sect , vol.38 , pp. 277-301
    • Riederer, P.1    Wuketich, S.2
  • 20
    • 0026589493 scopus 로고
    • Dopamine receptor interactions: Some implications for the treatment of Parkinson's disease
    • Robertson HA (1992) Dopamine receptor interactions: some implications for the treatment of Parkinson's disease. Trends Neurosci 15:201-206.
    • (1992) Trends Neurosci , vol.15 , pp. 201-206
    • Robertson, H.A.1
  • 21
    • 0029950147 scopus 로고    scopus 로고
    • GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice
    • Sagot Y, Tan SA, Hammang JP, Aebischer P, Kato AC (1996) GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J Neurosci 16:2335-2341.
    • (1996) J Neurosci , vol.16 , pp. 2335-2341
    • Sagot, Y.1    Tan, S.A.2    Hammang, J.P.3    Aebischer, P.4    Kato, A.C.5
  • 22
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal neurons following intrastriatal terminal lesions with 6-OHDA: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH (1994) Progressive degeneration of nigrostriatal neurons following intrastriatal terminal lesions with 6-OHDA: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59:401-415.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 23
    • 0029047329 scopus 로고
    • GDNF but not TGF-β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine-lesion
    • Sauer H, Rosenblad C, Björklund A (1995) GDNF but not TGF-β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine-lesion. Proc Natl Acad Sci USA 92:8935-8939.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenblad, C.2    Björklund, A.3
  • 24
    • 0027411599 scopus 로고
    • The role of positron emission tomography in the assessment of human neurotransplantation
    • Sawle GV, Myers R (1993) The role of positron emission tomography in the assessment of human neurotransplantation. Trends Neurosci 16:172-176.
    • (1993) Trends Neurosci , vol.16 , pp. 172-176
    • Sawle, G.V.1    Myers, R.2
  • 25
    • 0023769265 scopus 로고
    • Disengage sensorimotor deficit following apparent recovery from unilateral dopamine depletion
    • Schallert T, Hall S (1988) Disengage sensorimotor deficit following apparent recovery from unilateral dopamine depletion. Behav Brain Res 30:15-24.
    • (1988) Behav Brain Res , vol.30 , pp. 15-24
    • Schallert, T.1    Hall, S.2
  • 27
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
    • Ungerstedt U, Arbuthnott G (1970) Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res 24:485-493.
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.