Polymer-encapsulated PC-12 cells demonstrate high-affinity uptake of dopamine in vitro and 18F-dopa uptake and metabolism after intracerebral implantation in nonhuman primates

Cell Transplantation

Volumn 6, Issue 5, 1997, Pages 469-477

  Subramanian, Thyagarajan ^a,b   Emerich, Dwaine F ^c   Bakay, Roy A E ^a,b   Hoffman, John M ^a,d   Goodman, Mark M ^d   Shoup, Timothy M ^d   Miller, Gary W ^a   Levey, Allan I ^a   Hubert, George W ^a   Batchelor, Scott ^a   Winn, Shelly R ^c   Saydoff, Joel A ^c   Watts, Ray L ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c CytoTherapeutics Inc   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunoisolation; Parkinson's disease; PET; Transplantation

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CARBIDOPA; DOPAMINE; DOPAMINE TRANSPORTER; FLUORINE 18; GLIAL FIBRILLARY ACIDIC PROTEIN; NOMIFENSINE; POLYMER; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE METABOLISM; DOPAMINE UPTAKE; ENCAPSULATION; EXPLANT; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; MOTOR PERFORMANCE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARIETAL LOBE; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; WHITE MATTER;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BRAIN; CAPSULES; CARRIER PROTEINS; CELL TRANSPLANTATION; DIHYDROXYPHENYLALANINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; FLUORINE RADIOISOTOPES; GLIAL FIBRILLARY ACIDIC PROTEIN; MACACA MULATTA; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NOMIFENSINE; PARKINSON DISEASE, SECONDARY; PC12 CELLS; POLYMERS; POTASSIUM; RATS; TOMOGRAPHY, EMISSION-COMPUTED; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; PRIMATES;

EID: 12644289287     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0963-6897(97)00049-3     Document Type: Article

References (32)

1. Aebischer, P.; Buchser, E.; Joseph, J.M.; Favre, J.; de, T.N.; Lysaght, M.; Rudnick, S.; Goddard, M. Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report. Transplantation. 58:1275-1277; 1994.
2. Aebischer, P.; Goddard, M.; Signore, A.P.; Timpson, R.L. Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. Exp. Neurol. 126:151-158; 1994.
3. Aebischer, P.; Tresco, P.A.; Winn, S.R.; Greene, L.A.; Jaeger, C.B. Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line. Exp. Neurol. 111:269-275; 1991.
4. Aebischer, P.; Wahlberg, L.; Tresco, P.A.; Winn, S.R. Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution. Biomaterials 12:50-56; 1991.
5. Aebischer, P.; Winn, S.R.; Tresco, P.A.; Jaeger, C.B.; Greene, L. A. Transplantation of polymer encapsulated neurotransmitter secreting cells: Effect of the encapsulation technique. J. Biomech. Eng. 113:178-183; 1991.
6. Ciliax, B.J.; Heilman, C.; Demchyshyn, L.L.; Pristupa, Z.B.; Ince, E.; Hersch, S.M.; Niznik, H.B.; Levey, A.I. The dopamine transporter: immunochemical characterization and localization in brain. J. Neurosc. 15:1714-1723; 1995.
7. Emerich, D.F.; Winn, S.R.; Christenson, L.; Palmatier, M.A.; Gentile, F.T.; Sanberg, P.R. A novel approach to neural transplantation in Parkinson's disease: Use of polymer-encapsulated cell therapy. Neurosci. Biobehav. Rev. 16:437-447; 1992.
8. Freed, C.R.; Breeze, R.E.; Rosenberg, N.L.; Schneck, S.A.; Kriek, E.; Qi, J.X.; Lone, T.; Zhang, Y.B.; Snyder, J.A.; Wells, T.H.; et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N. Engl. J. Med. 327:1549-1555; 1992.
9. Freed, C.R.; Breeze, R.E.; Rosenberg, N.L.; Schneck, S.A.; Wells, T.H.; Barrett, J.N.; Grafton, S.T.; Mazziotta, J.C.; Eidelberg, D.; Rottenberg, D.A. Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. Prog. Brain Res. 82:715-721; 1990.
10. Freeman, T.B.; Olanow, C.W.; Hauser, R.A.; Nauert, G.M.; Smith, D.A.; Borlongan, C.V.; Sanberg, P.R.; Holt, D.A.; Kordower, J.H.; Vingerhoets, F.J.; et al. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann. Neurol. 38:379-388; 1995.
11. Hoffer, B.J.; Leenders, K.L.; Young, D.; Gerhardt, G.; Zerbe, G.O.; Bygdeman, M.; Seiger, A.; Olson, L.; Stromberg, I.; Freedman, R. Eighteen-month course of two patients with grafts of fetal dopamine neurons for severe Parkinson's disease. Exp. Neurol. 118:243-252; 1992.
12. Hoffman, J.M.; Melega, W.P.; Hawk, T.C.; Grafton, S.C.; Luxen, A.; Mahoney, D.K.; Barrio, J.R.; Huang, S.C.; Mazziotta, J.C.; Phelps, M.E. The effects of carbidopa administration on 6-[18F]fluoro-L-dopa kinetics in positron emission tomography. J. Nuclear Med. 33:1472-1477; 1992.
13. Jaeger, C.B.; Aebischer, P.; Tresco, P.A.; Winn, S.R.; Greene, L.A. Growth of tumour cell lines in polymer capsules: Ultrastructure of encapsulated PC12 cells. J. Neurocytol. 21:469-480; 1992.
14. Jaeger, C.B.; Greene, L.A.; Tresco, P.A.; Winn, S.R.; Aebischer, P. Polymer encapsulated dopaminergic cell lines as "alternative neural grafts." Prog. Brain Res. 82: 41-46; 1990.
15. Jaeger, C.B.; Winn, S.R.; Tresco, P.A.; Aebischer, P. Repair of the blood-brain barrier following implantation of polymer capsules. Brain Res. 551:163-170; 1991.
16. Kordower, J.H.; Freeman, T.B.; Snow, B.J.; Vingerhoets, F.J.; Mufson, E.J.; Sanberg, P.R.; Hauser, R.A.; Smith, D.A.; Nauert, G.M.; Perl, D.P.; et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332: 1118-1124; 1995.
17. Kordower, J.H.; Liu, Y.T.; Winn, S.; Emerich, D.F. Encapsulated PC12 cell transplants into hemiparkinsonian monkeys: A behavioral, neuroanatomical, and neurochemical analysis. Cell Transplant. 4:155-171; 1995.
18. Lavoie, M.P.; Palmatier, M.; Gentile, F.T.; Kaplan, F.A.; Fiore, D.M.; Hazlett, T.F.; Bell, W.J.; Flanagan, T.R. Two PC12 pheochromocytoma lines sealed in hollow fiberbased capsules tonically release L-dopa in vitro. Cell Transplant. 2:163-173; 1993.
19. Leenders, K.L.; Poewe, W.H.; Palmer, A.J.; Brenton, D.P.; Frackowiak, R.S. Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. Ann Neurol. 20:258-262; 1986.
20. Lindner, M.D.; Winn, S.R.; Baetge, E.E.; Hammang, J.P.; Gentile, F.T.; Doherty, E.; McDermott, P.E.; Frydel, B.; Ullman, M.D.; Schallert, T.; et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp. Neurol. 132:62-76; 1995.
21. Lindvall, O.; Sawle, G.; Widner, H.; Rothwell, J.C.; Bjorklund, A.; Brooks, D.; Brundin, P.; Frackowiak, R.; Marsden, C.D.; Odin, P.; et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann. Neurol. 35:172-180; 1994.
22. Lindvall, O.; Widner, H.; Rehncrona, S.; Brundin, P.; Odin, P.; Gustavii, B.; Frackowiak, R.; Leenders, K.L.; Sawle, G.; Rothwell, J.C.; et al. Transplantation of fetal dopamine neurons in Parkinson's disease: One-year clinical and neurophysiological observations in two patients with putaminal implants. Ann. Neural. 31:155-165; 1992.
23. Miller, G.W.; Staley, J.K.; Heilman, C.J.; Perez, J.T.; Mash, D.C.; Rye, D.B.; Levey, A.I. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Ann Neurol. 41:530-539; 1997.
24. Sawle, G.V.; Bloomfield, P.M.; Bjorklund, A.; Brooks, D.J.; Brundin, P.; Leenders, K.L.; Lindvall, O.; Marsden, C.D.; Rehncrona, S.; Widner, H.; et al. Transplantation of fetal dopamine neurons in Parkinson's disease: PET [18F]6-L-fluorodopa studies in two patients with putaminal implants. Ann. Neurol. 31:166-173; 1992.
25. Sawle, G.V.; Myers, R. The role of positron emission tomography in the assessment of human neurotransplantation [published erratum appears in Trends Neurosci. 1993 Jul;16(7):260]. Trends Neurosci. 16:172-176; 1993.
26. Snow, BJ. Fluorodopa PET scanning in Parkinson's disease. Adv. Neurol. 69:449-157; 1996.
27. Spencer, D.D.; Robbins, R.J.; Naftolin, F.; Marek, K.L.; Vollmer, T.; Leranth, C.; Roth, R.H.; Price, L.H.; Gjedde, A.; Bunney, B.S.; et al. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease [see comments]. N. Engl. J. Med. 327:1541-1548; 1992.
28. Staley, J.K.; Talbot, J.Z.; Ciliax, B.J.; Miller, G.W.; Levey, A.I.; Kung, M.; Kung, H.F.; Mash, D.C. Radioligand binding and immunoradiographic evidence for a lack of toxicity to dopaminergic nerve terminals in human cocaine overdose victims. Brain Res. 747:219-229; 1997.
29. Tresco, P.A.; Winn, S.R.; Tan, S.; Jaeger, C.B.; Greene, L.A.; Aebischer, P. Polymer-encapsulated PC12 cells: Long-term survival and associated reduction in lesion-induced rotational behavior. Cell Transplant. 1:255-264; 1992.
30. Winn, S.R.; Tresco, P.A.; Zielinski, B.; Greene, L.A.; Jaeger, C.B.; Aebischer, P. Behavioral recovery following intrastriatal implantation of microencapsulated PC 12 cells. Exp. Neurol. 113:322-329; 1991.
31. Winn, S.R.; Wahlberg, L.; Tresco, P.A.; Aebischer, P. An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats. Exp. Neurol. 105:244-250; 1989.
32. Woods, R.P.; Mazziotta, J.C.; Cherry, S.R. MRI-PET registration with automated algorithm. J. Comput. Assist. Tomogr. 17:536-546; 1993.