Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways

European Journal of Pharmacology

Volumn 324, Issue 2-3, 1997, Pages 249-255

  Germonpré, Paul R ^a   Joos, Guy F ^a   Mekeirele, Katia ^a   Pauwels, Romain A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

5 HT receptor; Airways; Capsaicin; Fisher 344 rat; Histamine receptor; Plasma protein extravasation; Tachykinin

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; ALPHA METHYLSEROTONIN; CAPSAICIN; CISAPRIDE; HISTAMINE RECEPTOR; KETANSERIN; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 2 RECEPTOR; SEROTONIN RECEPTOR; SUMATRIPTAN; TACHYKININ RECEPTOR; TROPISETRON;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXTRAVASATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CAPILLARY LEAK SYNDROME; CAPSAICIN; HISTAMINE ANTAGONISTS; MALE; RATS; RATS, INBRED F344; RECEPTORS, HISTAMINE; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0031002296     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00077-0     Document Type: Article

References (21)

1. Brokaw, J.J., White, G.W., 1992. Calcitonin gene-related peptide potentiates substance P-induced plasma extravasation in the rat trachea. Lung 170, 85-93.
2. Buckner, C.K., Dea, D., Liberati, N., Krell, R.D., 1991. A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig. J. Pharmacol. Exp. Ther. 257, 26-34.
3. Buzzi, M., Moskowitz, M.A., Peroutka, S.J., Byun, B., 1991. Further characterization of the putative 5-HT receptor which mediates blockade of neurogenic plasma protein extravasation in rat dura mater. Br. J. Pharmacol. 103, 1421-1428.
4. Buzzi, M.G., Moskowitz, M.A., 1990. The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br. J. Pharmacol. 99, 202-206.
5. Germonpré, P.R., Joos, G.F., Everaert, E., Kips, J.C., Pauwels, R.A., 1995. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Am. J. Respir. Crit. Care Med. 152, 1796-1804.
6. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylencharane, E.J., Saxena, P.R., Humphrey, P.P.A., 1994. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-203.
7. Hua, X.Y., Yaksh, T.L., 1992. Release of calcitonin gene-related peptide and tachykinins from the rat trachea. Peptides 13, 113-120.
8. Hua, X.Y., Yaksh, T.L., 1993. Pharmacology of the effects of bradykinin, serotonin, and histamine on the release of calcitonin gene related peptide from C-Fiber terminals in the rat trachea. J. Neurosci. 13, 1947-1953.
9. Huang, Z., Byun, B., Matsubara, T., Moskowitz, M.A., 1993. Time-dependent blockade of neurogenic plasma extravasation by 5-HT1B/D agonists and endopeptidase 24.11. Br. J. Pharmacol. 108, 331-335.
10. 3-receptors inhibit neurogenic microvascular leakage in airways. J. Appl. Physiol. 68, 21-25.
11. Joos, G.F., Pauwels, R.A., 1993. The in vivo effect of tachykinins on airway mast cells of the rat. Am. Rev. Respir. Dis. 148, 922-926.
12. Khalil, Z., Helme, R.D., 1990. Serotonin modulates substance P-induced plasma extravasation and vasodilatation in rat skin by an action through capsaicin-sensitive primary afferent nerves. Brain Res. 527, 292-298.
13. Lundberg, J.M., Brodin, E., Saria, A., 1983. Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs. Acta Physiol. Scand. 119, 243-252.
14. Lundberg, J.M., Saria, A., 1982. Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea. Acta. Physiol. Scand. 115, 521-523.
15. Maggi, C.A., Melli, A., 1988. The sensory-efferent functions of capsaicin-sensitive sensory neurons. Gen. Pharmacol. 19, 1-43.
16. Moreno, R.H., Hogg, J.C., Parré, P.D., 1986. Mechanics of airway narrowing. Am. Rev. Respir. Dis. 133, 1171-1180.
17. Moriarty, K.J., Higgs, N.B., Woodford, M., Warhurst, G., Turnberg, L.A., 1987. Inhibition of the effect of serotonin on rat ileal transport by cisapride: evidence in favour of the involvement of 5-HT2 receptors. Gut 28, 844-848.
18. Ohkubo, T., Shibata, M., Inoue, M., Kaya, H., Takahashi, H., 1995. Regulation of substance P release mediated via prejunctional histamine H3 receptors. Eur. J. Pharmacol. 273, 83-88.
19. Persson, C.G.A., 1988. The role of plasma exudation in asthma airways. Lancet ii, 1126-1129.
20. Saria, A., Lundberg, J.M., Skofitsch, G., Lembeck, F., 1983. Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn-Schmiedeberg's Arch. Pharmacol. 324, 212-218.
21. Ward, J.K., Fox, A.J., Barnes, P.J., Belvisi, M.G., 1994. Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor. Br. J. Pharmacol. 111, 1095-1102.