Tachykinin NK 3 and NK 1 receptor activation elicits secretion from porcine airway submucosal glands

British Journal of Pharmacology

Volumn 138, Issue 1, 2003, Pages 254-260

  Phillips, Jonathan E ^a   Hey, John A ^a   Corboz, Michel R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hillock; Mucus; Porcine airways; Submucosal gland secretion; Tachykinin agonists and antagonists; Trachea

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ATROPINE; HEXAMETHONIUM BROMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ A [4-10][8 BETA ALANINE]; NEUROKININ B [7 METHYLPHENYLALANINE]; SAREDUTANT; SUBSTANCE P; TALNETANT; 3-(2-METHOXYBENZYLAMINO)-2-PHENYLPIPERIDINE; BENZAMIDE DERIVATIVE; PIPERIDINE DERIVATIVE;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPERPOLARIZATION; MUCUS GLAND; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SWINE; TRACHEA MUCOSA; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EXOCRINE GLAND; METABOLISM; RESPIRATORY TRACT MUCOSA; SECRETION; TRACHEA;

ANIMALS; BENZAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOCRINE GLANDS; PIPERIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-3; RESPIRATORY MUCOSA; SWINE; TRACHEA;

EID: 0037272798     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705029     Document Type: Article

References (56)

1. 2) receptors. Am. Rev. Respir. Dis., 146, 1177-1181.
2. 2) receptor revisited with SR48968, a potent non-peptide antagonist. Biochem. Biophys. Res. Commun., 184, 1418-1424.
3. BAI, T.R., ZHOU, D., WEIR, T., WALKER, B., HEGELE, R., HAYASHI, S., MCKAY, K., BONDY, G.P. & FONG, T. (1995). Substance P and Neurokinin A-receptor gene expression in inflammatory airway diseases. Am. J. Physiol., 269, L309-L317.
4. BALLARD, S.T., SCHEPENS, S.M., FALCONE, J.C., MEININGER, G.A. & TAYLOR, A.E. (1992). Regional bioelectric properties of porcine airway epithelium. J. Appl. Physiol., 73, 2021-2027.
5. 3 receptors in airways by immunohistochemistry. Am. J. Respir. Crit. Care Med., 153, A161.
6. BARNES, P.J. (2001). Neurogenic inflammation in the airways. Respir. Physiol., 125, 145-154.
7. BELVISI, M.G., PATACCHINI, R., BARNES, P.J. & MAGGI, C.A. (1994), Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences. Br. J. Pharmacol., 111, 103-110.
8. CASTAIRS, J.R. & BARNES, P.J. (1986). Autoradiographic mapping of substance P receptors in the lung. Eur. J. Pharmacol., 127, 295-296.
9. CHOI, H.K., FINKBEINER, W.E. & WIDDICOMBE, J.H. (2000). A comparative study of mammalian tracheal mucous glands. J. Anat., 197, 361-372.
10. 3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. Am. J. Respir. Crit. Care Med., 158, 42-48.
11. 3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig. Br. J. Pharmacol., 130, 49-56.
12. DAVIS, B., MARIN, M., FISHER, S., GRAF, P., WIDDICOMBE, J. & NADEL, J. (1976). New method for study of canine mucous gland secretion in vivo: Cholinergic regulation. Am. Rev. Respir. Dis., 113, 257.
13. DONALDSON, S.H., PICHER, M. & BOUCHER, R.C. (2002). Secreted and cell-associated adenylate kinase and nucleoside diphosphokinase contribute to extracellular nucleotide metabolism on human airway surfaces. Am. J. Respir. Cell Mol. Biol., 26, 209-215.
14. GEPPETTI, P., BERTRAND, C., BACCI, E., HUBER, O. & NADEL, J.A. (1993). Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists. Am. J. Physiol. Lung Cell. Mol. Physiol., 265, L164-L169.
15. GOCO, R.V., KRESS, M.B. & BRANTIGAN, O.C. (1963). Comparison of mucus glands in the tracheobronchial tree of man and animals. Ann. N.Y. Acad. Sci., 106, 555-571.
16. 3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J. Neurosci., 16, 6975-6986.
17. GUARD, S. & WATSON, S.P. (1991). Tachykinin receptor types: Classification and membrane signaling mechanisms. Neurochem. Int., 18, 149-165.
18. HAXHIU, M.A., HAXHIU-POSKURICA, B., MORACIC, V., CARLO, W.A. & MARTIN, R.J. (1990). Reflex and chemical responses of tracheal submucosal glands in piglets. Respir. Physiol., 82, 267-278.
19. HAXHIU, M.A., TSENG, H.C. & DAVIS, B. (1988). Thiorphan enhances baseline and substance P induced tracheal gland secretion in dogs. Clin. Res., 36, 506A.
20. 2 receptors in the guinea-pig. J. Auton. Pharmacol., 16, 41-48.
21. HOOVER, D.B. & HANDCOCK, J.C. (1987). Autoradiographic localization of substance P binding sites in guinea-pig airways. J. Auton. Nerv. Syst., 19, 171-174.
22. JEFFERY, P.K. (1983). Morphologic features of airway surface epithelial cells and glands. Am. Rev. Respir. Dis., 128, S14-S20.
23. JONES, R., BASKERVILLE, A. & REID, L. (1975). Histochemical identification of glycoproteins in pig bronchial epithelium. J. Pathol., 116, 1-11.
24. JOO, N.S., WU, J.V., KROUSE, M.E., SAENZ, Y. & WINE, J.J. (2001). Optical method for quantifying rates of mucus secretion from single submucosal glands. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L458-L468.
25. JOOS, G.F., DESWERT, K.O. & PAUWELS, R.A. (2001). Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists. Eur. J. Pharmacol., 429, 239-250.
26. JOOS, G.F., GERMONPRE, P.R. & PAUWELS, R.A. (2000). Role of tachykinins in asthma. Allergy, 55, 321-337.
27. 1 receptor antagonist MEN11467 on tracheal mucus secretion in allergic ferrets. Br. J. Pharmacol., 132, 189-196.
28. 1 receptor antagonists on non-adrenergic, non-cholinergic neurogenic mucus secretion in ferret trachea. Eur. J. Pharmacol., 384, 173-181.
29. LUNDGREN, J.D., WIEDERMANN, C.J., LOGUN, C., PLUTCHOK, J., KALINER, M. & SHELHAMER, J.H. (1989). Substance P receptor-mediated secretion of respiratory glycoconjugate from feline airways in vitro. Exp. Lung Res., 15, 17-29.
30. MAGGI, C.A. (1995). The mammalian tachykinin receptors. Gen. Pharmac., 26, 911-944.
31. MCLEAN, S., GANONG, A., SEYMOUR, P.A., SNIDER, R.M., DESAI, M.C., ROSEN, T., BRYCE, D.K., LONGO, K.P., REYNOLDS, L.S., ROBINSON, G., SCHMIDT, A.W., SIOK, C. & HEYM, J. (1993). Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor. J. Pharmacol. Exp. Ther., 267, 472-479.
32. MEINI, S., MAK, J.C., ROHDE, J.A. & ROGERS, D.F. (1993). Tachykinin control of ferret airways: Mucus secretion, broncho-constriction and receptor mapping. Neuropeptides, 24, 81-89.
33. MIZOGUCHI, H. & HICKS, C.R. (1989). Effects of neurokinins on ion transport and sulfated macromolecule release in the isolated ferret trachea. Exp. Lung Res., 15, 837-848.
34. MYERS, A.C. & UNDEM, B.J. (1993). Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones. J. Physiol., 470, 665-679.
35. NADEL, J.A. & DAVIS, B. (1977). Autonomic regulation of mucus secretion and ion transport in airways. In Asthma: Physiology, Immunopharmacology, and Treatment. eds. Lichtenstein, L.M. & Austen, K.F. pp. 197-210. New York: Academic Press.
36. i rise in the acinar cells of feline tracheal submucosal gland. Respir. Physiol., 98, 111-120.
37. 3-receptor antagonist, SR 142801, in a murine model of asthma. Eur. J. Pharmacol., 421, 201-205.
38. PHILLIPS, J.E., HEY, J.A. & CORBOZ, M.R. (2002a). Automated measurement of airway gland secretions by the hillocks technique. Comput. Methods Programs Biomed., 68, 215-222.
39. PHILLIPS, J.E., HEY, J.A. & CORBOZ, M.R. (2002b). Effects of ion transport inhibitors on methacholine-mediated secretion from porcine airway submucosal glands. J. Appl. Physiol., 93, 873-881.
40. PHIPPS, R.J. (1981). The airway mucociliary system. In International Review of Physiology. ed. Widdicombe, J.G. pp. 216-260. Baltimore: University Park Press.
41. PIEDIMONTE, G. (1995). Tachykinin peptides, receptors and peptidases in airway disease. Exp. Lung Res., 21, 809-834.
42. RAMNARINE, S.I., HIRAYAMA, Y., BARNES, P.J. & ROGERS, D.F. (1994). 'Sensory-efferent' neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro. Br. J. Pharmacol., 113, 1183-1190.
43. RANGACHARI, P.K. & MCWADE, D. (1985). Effects of tachykinins on the electrical activity of isolated canine tracheal epithelium. Regul. Pept., 12, 9-19.
44. REGOLI, D., BOUDON, A. & FAUCHERE, J.-L. (1994). Receptors and antagonists for substance P and related peptides. Pharmacol. Rev., 46, 551-599.
45. 2-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle. Neuropeptides, 33, 27-34.
46. ROGERS, D.F. (2002). Mucoactive drugs for asthma and COPD: any place in therapy? Exp. Opin. Invest. Drugs, 11, 15-35.
47. ROGERS, D.F., AURSUDKIJ, B. & BARNES, P.J. (1989). Effects of tachykinins on mucus secretion in human bronchi in vitro. Eur. J. Pharmacol., 174, 283-286.
48. SARAU, H.M., GRISWOLD, D.E., POTTS, W., FOLEY, J.J., SCHMIDT, D.B., WEBB, E.F., MARTIN, L.D., BRAWNER, M.E., ELSHOURBAGY, N.A., MEDHURST, A.D., GIARDINA, G.A. & HAY, D.W. (1997). Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB223412, a novel, potent, and selective neurokinin-3 receptor antagonist. J. Pharmacol. Exp. Ther., 281, 1303-1311.
49. SPINA, D. & PAGE, C.P. (1996). Airway sensory nerves in asthma - targets for therapy? Pulm. Pharmacol., 9, 1-18.
50. SPINA, D., SHAH, S. & HARRISON, S. (1998). Modulation of sensory nerve function in the airways. Trends Pharmacol. Sci., 19, 460-466.
51. TROUT, L., CORBOZ, M.R. & BALLARD, S.T. (2001). Mechanism of substance P-induced liquid secretion across bronchial epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L639-L645.
52. UNDEM, B.J. & MYERS, A.C. (1997). Autonomic Ganglia. In Autonomic control of the respiratory system. ed. Barnes, P.J. pp. 87-118. Amsterdam: Harwood Academic.
53. USSING, H.H. (1949). The active ion transport through the isolated frog skin in the light of tracer studies. Acta Physiol. Scand., 17, 1-37.
54. WAGNER, U., FEHMANN, H.C., BREDENBROKER, D., KLUBER, D., LANGE, A. & VON WICHERT, P. (1999). Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat. Neuropeptides, 33, 55-61.
55. WAGNER, U., FEHMANN, H.C., BREDENBROKER, D., YU, F., BARTH, P.J. & VON WICHERT, P. (1995). Galanin and somatostatin inhibition of neurokinin A and B induced airway mucus secretion in the rat. Life Sci., 57, 283-289.
56. WU, D.X., LEE, C.Y., UYEKUBO, S.N., CHOI, H.K., BASTACKY, S.J. & WIDDICOMBE, J.H. (1998). Regulation of the depth of surface liquid in bovine trachea. Am. J. Physiol. Lung Cell. Mol. Physiol., 274, L388-L395.