Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 2, 1996, Pages 732-739

  Kudlacz, Elizabeth M ^a   Knippenberg, Robert W ^a   Logan, Deborah E ^a   Burkholder, Timothy P ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [3 (3,4 DICHLOROPHENYL) 1 (3,4,5 TRIMETOXYBENZOYL) PYRROLIDIN 3 YL] ETHYL] 4 PHENYLPIPERIDINE 4 CARBOXAMIDE; CAPSAICIN; HISTAMINE; MDL 105212; METHACHOLINE; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; OVALBUMIN; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; DRUG STRUCTURE; DYSPNEA; EXTRAVASATION; GUINEA PIG; HISTAMINE RELEASE; LUNG PRESSURE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY;

ANIMALS; BRONCHOCONSTRICTION; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HISTAMINE RELEASE; HYPERSENSITIVITY; MALE; OVALBUMIN; PIPERIDINES; PYRROLIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RESPIRATION;

EID: 0030431325     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. ABRAHAM, W. M., AHMED, A., CORTES, A., SOLER, M., FARMER, S. G., BAUGH, L. E. AND HARBESON, S. L.: Airway effects of inhaled bradykinin, substance P and neurokinin A in sheep. J. Allergy Clin. Immunol. 87: 557-564, 1991.
2. 2 receptor antagonist. Eur. J. Pharmacol. 250: 169-171, 1993.
3. BARNES, P. J., CHUNG, K. F. AND PAGE, C. P.: Inflammatory mediators and asthma. Pharmacol. Rev. 40: 49-84, 1988.
4. BERTRAND, C., GEPPETTI, P., BAKER, J., YAMAWAKI, I. AND NADEL, J. A.: Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. J. Immunol. 150: 1479-1485, 1993a.
5. BERTRAND, C., GEPPETTI, P., GRAF, P. D., FOERSI, A. AND NADEL, J. A.: Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs. Am. J. Physiol. 265: L507-L511, 1993b.
6. BERTRAND, C., NADEL, J. A., YAMAWAKI, I. AND GEPPETTI, P.: Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea. J. Immunol. 151: 4902-4907, 1993c.
7. 2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea pigs. Br. J. Pharmacol. 114: 259-261, 1995.
8. 2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs. J. Auton. Pharmacol. 15: 49-54, 1995.
9. CARDELL, L. O., UDDMAN, R. AND EDVINSSON, L.: Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma. Eur. Respir. J. 7: 2169-2173, 1994.
10. CHAPMAN, I. D., FOSTER, A. AND MORLEY, J.: The relationship between inflammation and hyperreactivity of the airways in asthma. Clin. Exper. Allergy 23: 168-171, 1993.
11. CHEUNG, D., VAN DER VEEN, H., DEN HARTIGH, J., DIJKMAN, J. H. AND STERK, P. J.: Effects of inhaled substance P on airway responsiveness to methacholine in asthmatic subjects in vivo. J. Appl. Physiol. 77: 1325-1332, 1994.
12. DO PATROCINIO, M., WARTH, T. N., MALDONADO, E. A. L., FERNEZLIAN, S. M., LEME, A. S., PERINI, A., SALDIVA, P. H. N. AND MARTINS, M. A.: Neurokinin depletion attenuates pulmonary changes induced by antigen challenge in sensitized guinea pigs. Am. J. Physiol. 268: L781-L788, 1995.
13. FRANCHI-MICHELI, S., GENTILINI, G., CIUFFI, M., LUZZI, S., BINDI, D. AND ZILLETTI, L.: Capsaicin and anaphylactic reactions in the guinea-pig. Agents and Actions 27: 166-168, 1989.
14. GENTILINI, G., FRANCHI-MICHELI, S., CIUFFI, M., BINDI, D. AND ZILLETTI, L.: Capsaicin and anaphylactic reactions in the guinea-pig airways. Agents and Actions 30: 92-94, 1990.
15. HEUER, H. O., WENZ, B., JENNEWEIN, H. M. AND URICH, K.: Dissociation of airway responsiveness and bronchoalveolar lavage (BAL) cell composition in sensitized guinea-pigs after daily inhalation of ovalbumin. Clin. Exp. Allergy 24: 682-689, 1994.
16. HSIUE, T.-R., GARLAND, A., RAY, D. W., HERSHENSON, M. B., LEFF, A. R. AND SOLWAY, J.: Endogenous sensory neuropeptide release enhances nonspecific airway responses in guinea pigs. Am. Rev. Respir. Dis. 146: 148-153, 1992.
17. JOOS, G. F., GERMONPRE, P. R., KIPS, J. C., PELEMAN, R. A. AND PAUWELS, R. A.: Sensory neuropeptides and the human lower airways: Present state and future directions. Eur. Respir. J. 7: 1161-1171, 1994.
18. KAWANO, O., KOHROGI, H., YAMAGUCHI, T., ARAKI, S. AND ANDO, M.: Neutral endopeptidase inhibitor potentiates allergic bronchoconstriction in guinea pigs in vivo. J. Appl. Physiol. 76: 185-190, 1993.
19. KOHROGI, H., YAMAGUCHI, T., KAWANO, O., HONDA, I., ANDO, M. AND ARAKI, S.: Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. Am. Rev. Respir. Dis. 144: 636-641, 1991.
20. 2 tachykinin receptors and their involvement in histamine release in a murine mast cell line. Neuropeptides 21: 65-72, 1992.
21. KUDLACZ, E. M., BAUGH, L. E., PORTER, W. P., KENNY, M. T. AND FARRELL, A. M.: Airway hyperresponsiveness in conscious parainfluenza virus type 3 infected guinea pigs: A time course study. Lab. Animal Science 43: 445-453, 1993a.
22. KUDLACZ, E. M. AND KNIPPENBERG, R. W.: In vitro and in vivo effects of tachykinins on immune cell function in guinea pig airways. J. Neuroimmunol. 60: 119-125, 1994.
23. 2 receptor antagonists. Eur. J. Pharmacol. 241: 17-25, 1993b.
24. KUDLACZ, E. M., SHATZEH, S. A., KNIPPENBERG, R. W., LOGAN, D. E., POIROT, M., VAN GIERSBERGEN, P. L. M. AND BURKHOLDER, T. P.: In vitro and in vivo characterization of MDL 105,212A, a non-peptide NK-1/NK-2 tachykinin receptor antagonist. J. Pharmacol. Exper. Ther. 277: 840-851, 1996.
25. KUSNER, E. J., BUCKNER, C. K., DEHAAS, C. J., LENGEL, D. J., MARKS, R. L. AND KRELL, R. D.: Tachykinin-induced dyspnea in conscious guinea pigs. Eur. J. Pharmacol. 210: 299-306, 1992.
26. LILLY, C. M., BAI, T. R., SHORE, S. A., HALL, A. E. AND DRAZEN, J. M.: Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am. J. Respir. Crit. Care Med. 151: 548-553, 1995a.
27. LILLY, C. M., HALL, A. E., RODGER, I. W., KOBZIK, L., HALEY, K. J. AND DRAZEN, J. M.: Substance P-induced histamine release in tracheally perfused guinea pig lungs. J. Appl. Physiol. 78: L234-L241, 1995b.
28. LOU, Y.-P.: Regulation of neuropeptide release from pulmonary capsaicin-sensitive afferents in relation to bronchoconstriction. Acta Physiol. Scand.: suppl. 612, 1-88, 1993.
29. LUNDBERG, J. M., BRODIN, E. AND SARIA, A.: Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs. Acta Physiol. Scand. 119: 243-262, 1983.
30. MAGGI, C. A.: Tachykinin receptors in the airways and lung: What should we block? Pharmacol. Res. 22: 527-540, 1990.
31. MAGGI, C. A.: The pharmacology of the efferent function of sensory nerves. J. Auton. Pharmac. 11: 173-208, 1991.
32. MAGGI, C. A., PATACCHINI, R., ROVERO, P. AND GIACHETTI, A.: Tachykinin receptors and tachykinin receptor antagonists. J. Auton. Pharmacol. 13: 23-93, 1993.
33. MANZINI, S., MAGGI, C. A., GEPPETTI, P. AND BACCIARELLI, C.: Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs. Eur. J. Pharmacol. 138: 307-308, 1987.
34. MARSHALL, J. S. AND WASERMAN, S.: Mast cells and the nerves-potential interactions in the context of chronic disease. Clin. Exper. Allergy 25: 102-110, 1995.
35. MARTLING, C. R.: Sensory nerves containing tachykinins and CGRP in the lower airways. Functional implications for bronchoconstriction, vasodilatation and protein extravasation. Acta Physiol. Scand.: suppl. 563, 1-57, 1987.
36. MATSUMOTO, T., ASHIDA, Y. AND TSUKUDA, R.: Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig. J. Pharmacol. Exp. Ther. 269: 1236-1244, 1994.
37. MATSUSE, T., THOMSON, R. J., CHEN, X.-R., SALARI, H. AND SCHELLENBERG, R. R.: Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. Am. Rev. Respir. Dis. 144: 368-372, 1991.
38. MCFADDEN, E. R. AND GILBERT, I. A.: Asthma. New Eng. J. Med. 327: 1928-1937, 1992.
39. NIEBER, K., BAUMGARTEN, C. R., RATHSACK, R., FURKERT, J., OEHME, P. AND KUNKEL, G.: Substance P and β-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. J. Allergy Clin. Immunol. 90: 646-652, 1992.
40. NIEBER, K., BAUMGARTEN, C., WITZEL, A., RATHSACK, R., OEHME, P., BRUNNEE, T., KLEINE-TEBBE, J. AND KUNKEL, G.: The possible role of substance P in the allergic reaction, based on two different provocation models. Int. Arch. Allergy Appl. Immunol. 94: 334-338, 1991.
41. NOVERAL, J. P. AND GHUNSTEIN, M. M.: Tachykinin regulation of airway smooth muscle cell proliferation. Am. J. Physiol. (Lung Cell. Mol. Physiol.) 269: L339-343, 1995.
42. OTSUKA, M. AND YOSHIOKA, K.: Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73: 229-308, 1993.
43. PAYAN, D. G.: The role of neuropeptides in inflammation. In Inflammation: Basic Principles and Clinical Correlates, 2nd ed. ed. by J. I. Gallin, I. M. Goldstein and R. Snyderman, Raven Press, NY 177-192, 1992.
44. PRETOLANI, M., RUFFIE, C., JOSEPH, D., CAMPOS, M. G., CHURCH, M. K., LEFORT, J. AND VARGAFTIG, B. B.: Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs. Am. J. Respir. Crit. Care Med. 149: 1167-1174, 1994.
45. 2 receptors. J. Pharmacol. Exp. Ther. 262: 957-963, 1992.
46. RICCIARDOLO, F. L. M., NADEL, J. A., GRAF, P. D., BERTRAND, C., YOSHIHARA, S. AND GEPPETTI, P.: Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs. Br. J. Pharmacol. 113: 508-512, 1994.
47. RICE, A., HOLMES, M., THORNTON, A., REYNOLDS, P. AND SCICCHITANO, R.: Tachykinins contribute to immediate allergic airways response in sheep. Am. J. Respir. Crit. Care Med. 151: A346, 1995.
48. SAKUMA, Y., KATAYAMA, S., TSUNODA, H., ABE, S., YAMATSU, I. AND KATAYAMA, K.: Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. Int. Arch. Allergy Immunol. 97: 267-273, 1992.
49. SARIA, A., MARTLING, C.-R., YAN, Z., THEODORSSON-NORHEM, E., GAMSE, R. AND LUNDBERG, J. M.: Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine dimethylphenyl piperazinium and vagal nerve stimulation. Am. Rev. Respir. Dis. 137: 1330-1335, 1988.
50. SEKIZAWA, K., EBIHARA, T. AND SASAKI, H.: Role of substance P in cough during bronchoconstriction in awake guinea pigs. Am. J. Respir. Crit. Care Med. 151: 815-821, 1995.
51. STRATH, M., WARREN, D. J. AND SANDERSON, C. J.: Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors. J. Immunol. Meth. 83: 209-215, 1985.
52. TOMAKI, M., ICHINOSE, M., MIURA, M., HIRAYAMA, Y., YAMAUCHI, H., NAKAJIMA, N. AND SHIRATO, K.: Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am. J. Respir. Crit. Care Med. 151: 613-617, 1995.
53. UMENO, E., HIROSE, T. AND NISHIMA, S.: Pretreatment with aerosolized capsaicin potentiates histamine-induced bronchoconstriction in guinea pigs. Am. Rev. Respir. Dis. 146: 159-162, 1992.
54. WEERSINK, E. J. M., POSTMA, D. S. AND DE MONCHY, J. G. R.: Early and late asthmatic reaction after allergen challenge. Resp. Med. 88: 103-114, 1994.
55. WELTON, A. F., HOPE, W. C., O'DONNELL, M., BARUTH, H., CROWLEY, H. J., MILLER, D. A. AND YAREMKO, B.: Ro 22-3747: A new antiallergic agent for the treatment of immediate hypersensitivity diseases. J. Pharmacol. Exp. Ther. 228: 57-64, 1984.