The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics

European Respiratory Journal

Volumn 12, Issue 1, 1998, Pages 17-23

  Van Schoor, J ^a   Joos, G F ^a   Chasson, B L ^b   Brouard, R J ^b   Pauwels, R A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b SANOFI   (France)

Author keywords

Asthma; Bronchoconstriction; Neurokinin A; Tachykinin receptor antagonists; Tachykinins

Indexed keywords

METHACHOLINE; NEUROKININ A; PLACEBO; SALBUTAMOL; SAREDUTANT; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADULT; AIRWAY CONDUCTANCE; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FORCED EXPIRATORY VOLUME; GAS CHROMATOGRAPHY; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL;

ADULT; ASTHMA; BENZAMIDES; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; NEUROKININ A; PIPERIDINES; RECEPTORS, NEUROKININ-2; TREATMENT OUTCOME;

EID: 0031815845     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.12010017     Document Type: Article

References (41)

1. Lundberg JM, Saria A. Polypeptide-containing neurons in airway smooth muscle. Annu Rev Physiol 1987; 49: 557-572.
2. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part I. Am Rev Respir Dis 1991; 144: 1187-1198.
3. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis 1991; 144: 1391-1399.
4. Lundberg JM, Hökfelt T, Martling CR, Saria A, Cuello C. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res 1984; 235: 251-261.
5. Martling CR, Theodorsson-Norheim E, Lundberg JM. Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways. Life Sci 1987; 40: 1633-1643.
6. Komatsu T, Yamamoto M, Shimokata K, Nagura H. Distribution of substance P-immunoreactive and calcitonin gene-related peptide-immunoreactive nerves in normal human lungs. Int Arch Allergy Appl Immunol 1991; 95: 23-28.
7. Luts A, Uddman R, Alm P, Basterra J, Sundler F. Peptide-containing nerve fibers in human airways: distribution and coexistence pattern. Int Arch Allergy Immunol 1993; 101: 52-60.
8. Sheldrick RLG, Rabe KF, Fischer A, Magnussen H, Coleman RA. Further evidence that tachykinin-induced contraction of human isolated bronchus is mediated only by NK2-receptors. Neuropeptides 1995; 29: 281-292.
9. Maggi CA. The effects of tachykinins on inflammatory and immune cells. Regul Peptides 1997; 70: 75-90.
10. Lilly CM, Bai TR, Shore SA, Hall AE, Drazen JM. Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am J Respir Crit Care Med 1995; 151: 548-553.
11. Nieber K, Baumgarten CR, Rathsack R, Furkert J, Oehme P, Kunkel G. Substance P and β-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. J Allergy Clin Immunol 1992; 90: 646-652.
12. Tomaki M, Ichinose M, Miura M, et al. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am J Respir Crit Care Med 1995; 151: 613-617.
13. Advenier C, Naline E, Drapeau G, Regoli D. Relative potencies of neurokinins in guinea pig trachea and human bronchus. Eur J Pharmacol 1987; 139: 133-137.
14. Frossard N, Barnes PJ. Effect of tachykinins in small human airways. Neuropeptides 1991; 19: 157-161.
15. Joos G Pauwels R, Van Der Straeten M. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 1987; 42: 779-783.
16. Crimi N, Palermo F, Oliveri R, et al. Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects. Clin Allergy 1988; 18: 375-382.
17. Cheung D, Bel EH, Den Hartigh J, Dijkman JH, Sterk PJ. The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. Am Rev Respir Dis 1992; 145: 1275-1280.
18. Maggi CA. Tachykinin receptors and airway pathophysiology. Eur Respir J 1993; 6: 735-742.
19. Adcock IM, Peters M, Gelder C, Shirasaki H, Brown CR, Barnes PJ. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J Mol Endocrinol 1993; 11: 1-7.
20. Bai TR, Zhou D, Weir T, et al. Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases. Am J Physiol 1995; 269; L309-L317.
21. Naline E, Devillier P, Drapeau G, et al. Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am Rev Respir Dis 1989; 140: 679-686.
22. Advenier C, Naline E, Toty L, et al. Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors. Am Rev Respir Dis 1992; 146: 1177-1181.
23. Ellis JL, Undem BJ, Kays JS, Ghanekar SV, Barthlow HG, Buckner CK. Pharmacological examination of receptors mediating contractile responses to tachykinins in airways isolated from human, guinea pig and hamster. J Pharmacol Exp Ther 1993; 267: 95-101.
24. Chitano P, Di Blasi P, Lucchini RE, et al. The effects of toluene diisocyanate and of capsaicin on human bronchial smooth muscle in vitro. Eur J Pharmacol Environ Toxicol Pharmacol 1994; 270: 167-173.
25. Naline E, Molimard M, Regoli D, Emonds-Alt X, Bellamy JF, Advenier C. Evidence for functional tachykinin NK1 receptors on human isolated small bronchi. Am J Physiol 1996; 271: L763-L767.
26. Emonds-Alt X, Vilain P, Goulaouic P, et al. A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci 1992; 50: PL101-PL106.
27. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136: 225-244.
28. Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977; 7: 235-243.
29. 4 in normal subjects. Am Rev Respir Dis 1987; 136: 979-984.
30. Joos GF, Kips JC, Pauwels RA. In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains. Am J Respir Crit Care Med 1994; 149: 1160-1166.
31. Emonds-Alt X, Proietto V, Van Broeck D, et al. Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor. Bioorg Med Chem Lett 1993; 3: 925-930.
32. Emonds-Alt X, Advenier C, Soubrié P, Le Fur G, Brelière JC. SR 48968: nonpeptide antagonist of the tachykinin NK2 receptor. Drugs Fut 1995; 20: 701-707.
33. Maggi CA, Patacchini R, Rovero P, Santicioli P. Tachykinin receptors and noncholinergic bronchoconstriction in the guinea-pig isolated bronchi. Am Rev Respir Dis 1991; 144: 363-367.
34. Pauwels R, Joos G, Van Der Straeten M. Bronchial hyper-responsiveness is not bronchial asthma. Clin Allergy 1988; 18: 317-321.
35. Joos GF, Germonpre PR, Kips JC, Peleman RA, Pauwels RA. Sensory neuropeptides and the human lower airways: present state and future directions. Eur Respir J 1994; 7: 1161-1171.
36. Ichinose M, Nakajima N, Takahashi T, Yamauchi H, Inoue H, Takishima T. Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Lancet 1992; 340: 1248-1251.
37. Schmidt D, Jörres RA, Rabe KF, Magnussen H. Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-224 in asthmatic subjects. Eur J Clin Pharmacol 1996; 50: 269-273.
38. Joos GF, Van Schoor J, Kips JC, Pauwels RA. The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics. Am J Respir Crit Care Med 1996; 153: 1781-1784.
39. Ichinose M, Miura M, Yamauchi H, et al. A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. Am J Respir Crit Care Med 1996; 153: 936-941.
40. Fahy JV, Wong HH, Geppetti P, et al. Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Am J Respir Crit Care Med 1995; 152: 879-884.
41. Advenier C, Lagente V, Boichot E. The role of tachykinin receptor antagonists in the prevention of bronchial hyper-responsiveness, airway inflammation and cough. Eur Respir J 1997; 10: 1892-1906.