A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 3, 1996, Pages 936-941

  Ichinose, Masakazu ^a   Miura, Motohiko ^a   Yamauchi, Hideyuki ^a   Kageyama, Natsuko ^a   Tomaki, Masafumi ^a   Oyake, Tatsuya ^a   Ohuchi, Yuzuru ^a   Hida, Wataru ^a   Miki, Hiroshi ^a   Tamura, Gen ^a   Shirato, Kunio ^a,b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR;

ADULT; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE INDUCED ASTHMA; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL;

EID: 9044235778     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.3.8630576     Document Type: Article

References (33)

1. McFadden, E. R., Jr., and I. A. Gilbert. 1994. Exercise-induced asthma. N. Engl. J. Med. 330:1362-1367.
2. Poppius, H., A. Miuttari, K.-E. Kreus, O. Korhonen, and A. Viljanen. 1970. Exercise asthma and disodium cromoglycate. B.M.J. 4:337-339.
3. Jones, R. S., M. H. Buston, and M. J. Wharton. 1962. The effect of exercise on ventilatory function in the child with asthma. Br. J. Dis. Chest 56:78-86.
4. Strauss, R. H., E. R. McFadden, Jr., R. H. Ingram, Jr., and J. J. Jaeger. 1977. Enhancement of exercise-induced asthma by cold air. N. Engl. J. Med. 297:743-747.
5. Strauss, R. H., E. R. McFadden, Jr., R. H. Ingram, Jr., E. C. Deal, Jr., and J. J. Jaeger. 1978. Influence of heat and humidity on the airway obstruction induced by exercise in asthma. J. Clin. Invest. 61:433-440.
6. Ray, D., C. Hernandez, N. Munoz, A. R. Leff, and J. Solway. 1988. Bronchoconstriction elicited by dry air hyperpnea in guinea pigs. J. Appl. Physiol. 65:934-939.
7. Solway, J., and A. R. Leff. 1991. Sensory neuropeptides and airway functions. J. Appl. Physiol. 71:2077-2087.
8. Ray, D. W., C. Hernandez, A. R. Leff, J. M. Drazen, and J. Solway. 1989. Tachykinins mediate bronchoconstriction elicited by isocapnic hyperpnea in guinea pigs. J. Appl. Physiol. 66:1108-1112.
9. McFadden, E. R., Jr. 1990. Hypothesis: exercise-induced asthma as a vascular phenomenon. Lancet 335:880-883.
10. McFadden, E. R., Jr., and R. H. Ingram, Jr. 1988. Relationship between disease of the heart and lungs. In E. Braunwald, editor. Heart Disease. W. B. Saunders, Philadelphia. 1870-1882.
11. Barnes, P. J., J. Baraniuk, and M. G. Belvisi. 1991. Neuropeptides in the respiratory tract. Am. Rev. Respir. Dis. 144:1187-1198.
12. 1 receptor antagonist. Br. J. Pharmacol. 111:1342-1346.
13. 1 receptor antagonist, FK 888. Br. J. Pharmacol. 107:785-789.
14. American Thoracic Society. 1987. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Respir. Dis. 136:225-244.
15. Ichinose, M., N. Nakajima, T. Takahashi, H. Yamauchi, H. Inoue, and T. Takishima. 1992. Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Lancet 340:1248-1251.
16. Spector, S. L. 1993. Bronchial provocation tests. In E. B. Weiss and M. Stein, editors. Bronchial Asthma: Mechanisms and Therapeutics, 3rd ed. Little, Brown and Co., Boston. 501-516.
17. Barnes, P. J., K. F. Chung, and C. P. Page. 1988. Inflammatory mediators and asthma. Pharmacol. Rev. 40:49-84.
18. Latimer, K. M., P. M. O'Bryne, M. M. Morris, R. Roberts, and F. E. Hargreave. 1983. Bronchoconstriction stimulated by airway cooling: better protection with combined inhalation of terbutaline sulphate and cromolyn sodium than with either alone. Am. Rev. Respir. Dis. 128:440-443.
19. Ahmed, T., J. Garrigo, and I. Danta. 1993. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N. Engl. J. Med. 329:90-95.
20. O'Bryne, P. M., N. C. Thomson, M. Morris, R. S. Roberts, E. E. Daniel, and F. E. Hargreave. 1983. The protective effect of inhaled chlorpheniramine and atropine on bronchoconstriction stimulated by airway cooling. Am. Rev. Respir. Dis. 128:611-617.
21. 4-receptor antagonist. N. Engl. J. Med. 323:1736-1739.
22. Israel, E., R. Dermarkarian, M. Rosenberg, R. Sperling, G. Taylor, P. Rubin, and J. M. Drazen. 1990. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N. Engl. J. Med. 323: 1740-1744.
23. Barnes, P. J. 1986. Neural control of human airways in health and disease. Am. Rev. Respir. Dis. 134:1289-1314.
24. Tinkelman, D. G., M. J. Cavanaugh, and D. M. Cooper. 1976. Inhibition of exercise-induced bronchospasm by atropine. Am. Rev. Respir. Dis. 114:87-94.
25. Sheppard, D., J. Epstein, M. J. Holtzman, J. A. Nadel, and H. A. Boushey. 1982. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine. J. Appl. Physiol. 53:169-174.
26. Gross, N. J., and M. S. Skorodin. 1984. Anticholinergic, antimuscarinic bronchodilators. Am. Rev. Respir. Dis. 129:856-870.
27. Garland, A., D. W. Ray, C. M. Doerschuk, L. Alger, S. Eappon, C. Hernandez, M. Jackson, and J. Solway. 1991. Role of tachykinins in hyperpnea-induced bronchovascular hyperpermeability in guinea pigs. J. Appl. Physiol. 70:27-35.
28. Garland, A., J. E. Jordan, J. Necheles, L. E. Alger, M. M. Scully, R. J. Miller, D. W. Ray, S. R. White, and J. Solway. 1995. Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture. J. Clin. Invest. 95:2359-2366.
29. Naline, E., P. Devillier, G. Drapeau, L. Toty, H. Bakdach, D. Regoli, and C. Advenier. 1989. Characterization of neurokinin effects and receptor selectivity in human isolated bronchi. Am. Rev. Respir. Dis. 140:679-686.
30. 1 binding sites between human and guinea pig lung. Br. J. Pharmacol. 113:1407-1415.
31. Solway, J., B. M. Kao, J. E. Jordan, B. Gitter, I. W. Rodger, J. J. Howbert, L. E. Alger, J. Necheles, A. R. Leff, and A. Garland. 1993. Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs. J. Clin. Invest. 92:315-323.
32. Dion, S., P. D'Orleans-Juste, G. Drapeau, N.-E. Rhaleb, N. Rouissi, C. Tousignant, and D. Regoli. 1987. Characterization of neurokinin receptors in various isolated organs by the use of selective agonists. Life Sci. 41:2269-2278.
33. Dunill, M. S. 1960. The pathology of asthma with special reference to changes in the bronchial mucosa. J. Clin. Pathol. 13:27-33.