Airway inflammation and tachykinins: Prospects for the development of tachykinin receptor antagonists

European Journal of Pharmacology

Volumn 429, Issue 1-3, 2001, Pages 239-250

  Joos, Guy F ^a   De Swert, Katelijne O ^a   Pauwels, Romain A ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Airway inflammation; Asthma; Neurokinin A; Substance P; Tachykinin receptor

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ACETYLCHOLINE; ASTEMIZOLE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ A; OSANETANT; SAREDUTANT; TACHYKININ; TACHYKININ RECEPTOR ANTAGONIST;

AIRWAY; ALLERGY; ASTHMA; BRONCHOSPASM; CHOLINERGIC NERVE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COUGHING; ENZYME MECHANISM; EXTRAVASATION; HUMAN; IMMUNOCOMPETENT CELL; MUCUS SECRETION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REVIEW; SENSORY NERVE;

ANIMALS; ASTHMA; BRONCHI; HUMANS; INFLAMMATION; RECEPTORS, TACHYKININ; TACHYKININS;

EID: 0035840829     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01323-1     Document Type: Review

References (137)

1. Effect of synthetic tachykinin analogues on airway microvascular leakage in rats and guinea-pigs: Evidence for involvement of NK1 receptors
2. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids
3. Relative potencies of neurokinins in guinea-pig trachea and human bronchus
4. Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors
5. Impaired IL-1beta-induced neutrophil accumulation in tachykinin NK1 receptor knockout mice
6. NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi
7. Substance-P selectively activates TNF-alpha gene expression in murine mast cells
8. Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway disease
9. NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules
10. Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans
11. Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11] substance P in isolated human bronchi
12. Asthma as an axon reflex
13. Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP
14. Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea
15. Tachykinins, via NK1 receptor activation, play a relevant role in plasma protein extravasation evoked by allergen challenge in the airways of sensitized guinea-pigs
16. Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs
17. Role of substance P and the neurokinins receptor in acute pancreatitis and pancreatitis-associated lung injury
18. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine
19. Neurokinin A with K+ channel blockade potentiates contraction to electrical stimulation in human bronchus
20. Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat
21. Nerve growth factor: An important molecule in allergic inflammation and tissue remodelling
22. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation
23. Neurogenic amplification of immune complex inflammation
24. The role of neurotrophins in allergic bronchial asthma
25. Use of NK(1) knockout mice to analyze substance P-induced edema formation
26. Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: An in vivo study using neurokinin-1 receptor knockout mice
27. Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma
28. Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis
29. Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases
30. Substance P and its receptor neurokinin 1 expression in asthmatic airways
31. Modulation of acetylcholine release in rabbit airways in vitro
32. Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects
33. Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P
34. The effect of oral terfenadine on neurokinin-A induced bronchoconstriction
35. Further characterisation of substance P induced histamine release from human bronchoalveolar lavage mast cells
36. Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea
37. Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs
38. Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pig
39. Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord
40. Effects of capsaicin on the endothelial permeability in isolated and perfused rabbit lungs
41. Role of neuropeptides in acetylcholine-induced edema in isolated and perfused rabbit lungs
42. CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects
43. 1 receptor knock-out mice
44. The absence of the tachykinin NK1 receptor (NK1R) enhances baseline carbachol airway responsiveness but does not modulate allergen induced airway inflammation
45. Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs
46. Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors
47. A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor
48. The effects of substance P on histamine and 5-hydroxytryptamine release in the rat
49. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation
50. Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation
51. Virus-induced airway hyperresponsiveness and asthma
52. Effect of tachykinins in small human airways
53. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains
54. Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways
55. Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro
56. Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells
57. Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig
58. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice
59. Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves
60. Ozone-induced increases in substance P and 8-epi-prostaglandin F2a in the airways of human subjects
61. Substance-P induces histamine-release from human pulmonary mast-cells
62. Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fliud in normal and asthmatic subjects
63. Effects of 2 novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo
64. Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects
65. Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor
66. Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons
67. Effects of neurokinin receptor antagonists in virus-infected airways
68. Picomolar doses of substance P trigger electrical responses in mast cells without degranulation
69. The in vivo effect of tachykinins on airway mast cells in the rat
70. Pro-inflammatory effects of substance P: New perspectives for the treatment of airway diseases?
71. Tachykinin receptor antagonists: Potential in airways disease
72. The effect of oxitropium-bromide on neurokinin A-induced bronchoconstriction in asthmatics
73. The mechanism of tachykinin-induced bronchoconstriction in the rat
74. The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma
75. Sensory neuropeptides and the human lower airways: Present state and future directions
76. The effect of inhaled FK244, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics
77. Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro
78. Role of tachykinins in asthma
79. The leukotriene receptor antagonist zafirlukast inhibits neurokinin-A induced bronchoconstriction in patients with asthma
80. The effect of the dual NK1/NK2 tachykinin receptor antagonist DNK333A on neurokinin A-induced bronchoconstriction in patients with asthma
81. Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle
82. Effect of the long-acting tachykinin NK1 receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets
83. Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor in human lung - Distribution and regulation of leukemia inhibitory factor release
84. Leukaemia inhibitory factor (leukemia inhibitory factor) upregulates excitatory non-adrenergic non-cholinergic and maintains cholinergic neural function in tracheal explants
85. Neutral endo-peptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs
86. Role of neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs
87. Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans
88. C-terminal substance-P fragments elicit histamine release from a murine mast cell line
89. Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model
90. Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation
91. Neuropeptide content of lungs from asthmatic and nonasthmatic patients
92. Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis
93. Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide
94. Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea
95. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants
96. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
97. Peptide-containing nerve fibers in human airways: Distribution and coexistence pattern
98. The effects of tachykinins on inflammatory and immune cells
99. The troubled story of tachykinins and neurokinins
100. Dichotomy between neurokinin receptor actions in modulating allergic airway responses in an animal model of helper T cell type 2 cytokine-associated inflammation
101. The effect of phosphoramidon and epithelium removal on toluene diisocyanate-induced contractions in guinea-pig bronchi
102. The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways
103. Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways
104. Serotonin unmasks functional NK-2 receptors in vagal sensory neurones of the guinea-pig
105. Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents
106. Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs
107. G-protein activation: A receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides
108. Substance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output
109. Evidence for functional tachykinin NK1 receptors on human isolated small bronchi
110. 3-receptor antagonist, SR 142801, in a murine model of asthma
111. Substance P and β-endorphine-like immunoreactivity in lavage fluids of subjects with and without allergic asthma
112. Abnormal intraepithelial airway nerves in persistent unexplained cough?
113. Functional neurokinin NK-1 receptor expression in rat peritoneal mast cells
114. Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics
115. Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline
116. NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways
117. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs
118. Effects of capsaicin, (+/-)-CP 96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs
119. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis
120. Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge
121. The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways
122. Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammation cell influx in conscious, unrestrained guinea-pigs
123. Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea-pigs
124. Further evidence that tachykinin-induced contraction of human isolated bronchus is mediated only by NK2 receptors
125. A potent nonpeptide antagonist of the substance P (NK1) receptor
126. 5-HT2 receptors augment cholinergic nerve-mediated contraction of rat bronchi
127. Mechanisms of substance P-induced contraction of rabbit airway smooth muscle
128. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis
129. NK2 receptors mediate plasma extravasation in guinea-pig lower airways
130. Evidence for substance P as an endogenous substance causing cough in guinea pigs
131. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation
132. Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea
133. Allergic inflammation in isolated vagal sensory ganglia unmasks silent NK-2 tachykinin receptors
134. Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: Role of tachykinins
135. Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis
136. Plasma extravasation in the rat trachea induced by cold air is mediated by tachykinin release from sensory nerves
137. Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs