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Volumn 24, Issue 2-3, 2006, Pages 195-201

Thioflavins released from nanoparticles target fibrillar amyloid β in the hippocampus of APP/PS1 transgenic mice

Author keywords

Alzheimer's disease; Drug delivery; Drug targeting; Dynamic light scattering; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN; CYANOACRYLATE; DRUG CARRIER; ESTERASE; POLYMER; POLYSTYRENE; THIOFLAVINE;

EID: 33644553876     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2005.11.012     Document Type: Conference Paper
Times cited : (57)

References (58)
  • 2
    • 0035831189 scopus 로고    scopus 로고
    • β-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology
    • J. Apelt, and R. Schliebs β-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology Brain Res. 894 2001 21 30
    • (2001) Brain Res. , vol.894 , pp. 21-30
    • Apelt, J.1    Schliebs, R.2
  • 4
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview. Structure, regulation, and clinical implications
    • P. Ballabh, A. Braun, and M. Nedergaard The blood-brain barrier: an overview. Structure, regulation, and clinical implications Neurobiol. Dis. 16 2004 1 13
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 5
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • D.J. Begley Delivery of therapeutic agents to the central nervous system: the problems and the possibilities Pharmacol. Therapeut. 104 2004 29 45
    • (2004) Pharmacol. Therapeut. , vol.104 , pp. 29-45
    • Begley, D.J.1
  • 8
    • 0037239852 scopus 로고    scopus 로고
    • Emerging beta-amyloid therapies for the treatment of Alzheimer's disease
    • K.A. Conway, E.W. Baxter, K.M. Felsenstein, and A.B. Reitz Emerging beta-amyloid therapies for the treatment of Alzheimer's disease Curr. Pharm. Des. 9 2003 427 447
    • (2003) Curr. Pharm. Des. , vol.9 , pp. 427-447
    • Conway, K.A.1    Baxter, E.W.2    Felsenstein, K.M.3    Reitz, A.B.4
  • 9
    • 0037200117 scopus 로고    scopus 로고
    • Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
    • K.N. Dahlgren, A.M. Manelli, W.B. Stine Jr., L.K. Baker, G.A. Krafft, and M.J. LaDu Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability J. Biol. Chem. 277 2002 32046 32053
    • (2002) J. Biol. Chem. , vol.277 , pp. 32046-32053
    • Dahlgren, K.N.1    Manelli, A.M.2    Stine Jr., W.B.3    Baker, L.K.4    Krafft, G.A.5    Ladu, M.J.6
  • 10
    • 0035968202 scopus 로고    scopus 로고
    • Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites
    • G.V. De Ferrari, W.D. Mallender, N.C. Inestrosa, and T.L. Rosenberry Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites J. Biol. Chem. 276 2001 23282 23287
    • (2001) J. Biol. Chem. , vol.276 , pp. 23282-23287
    • De Ferrari, G.V.1    Mallender, W.D.2    Inestrosa, N.C.3    Rosenberry, T.L.4
  • 11
    • 0037361260 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease: Will vaccination work?
    • J.-C. Dodart, K.R. Bales, and S.M. Paul Immunotherapy for Alzheimer's disease: will vaccination work? Trends Mol. Med. 9 2003 85 87
    • (2003) Trends Mol. Med. , vol.9 , pp. 85-87
    • Dodart, J.-C.1    Bales, K.R.2    Paul, S.M.3
  • 12
    • 0034904844 scopus 로고    scopus 로고
    • Progress in the modeling of neurodegenerative diseases in transgenic mice
    • K. Duff, and M.V. Rao Progress in the modeling of neurodegenerative diseases in transgenic mice Curr. Opin. Neurol. 14 2001 441 447
    • (2001) Curr. Opin. Neurol. , vol.14 , pp. 441-447
    • Duff, K.1    Rao, M.V.2
  • 13
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • R. Duncan The dawning era of polymer therapeutics Nat. Rev. Drug Discov. 2 2003 347 360
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 347-360
    • Duncan, R.1
  • 15
    • 1842832660 scopus 로고    scopus 로고
    • Influence of surface charge density on protein adsorption on polymeric nanoparticles: Analysis by two-dimensional electrophoresis
    • A. Gessner, A. Lieske, B.-R. Paulke, and R.H. Müller Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis Eur. J. Pharm. Biopharm. 54 2002 165 170
    • (2002) Eur. J. Pharm. Biopharm. , vol.54 , pp. 165-170
    • Gessner, A.1    Lieske, A.2    Paulke, B.-R.3    Müller, R.H.4
  • 18
  • 20
    • 0037468315 scopus 로고    scopus 로고
    • Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: Implications for targeting β-amyloid in Alzheimer's disease
    • W. Härtig, B.-R. Paulke, C. Varga, J. Seeger, T. Harkany, and J. Kacza Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting β-amyloid in Alzheimer's disease Neurosci. Lett. 338 2003 174 176
    • (2003) Neurosci. Lett. , vol.338 , pp. 174-176
    • Härtig, W.1    Paulke, B.-R.2    Varga, C.3    Seeger, J.4    Harkany, T.5    Kacza, J.6
  • 23
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small Aβ oligomers: The solution to an Alzheimer's disease conondrum?
    • W.I. Klein, G.A. Krafft, and C.E. Finch Targeting small Aβ oligomers: the solution to an Alzheimer's disease conondrum? Trends Neurosci. 24 2001 219 224
    • (2001) Trends Neurosci. , vol.24 , pp. 219-224
    • Klein, W.I.1    Krafft, G.A.2    Finch, C.E.3
  • 24
    • 0035902875 scopus 로고    scopus 로고
    • Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    • W.E. Klunk, Y. Wang, G. Huang, M.L. Debnath, D.P. Holt, and C.A. Mathis Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain Life Sci. 69 2001 1471 1484
    • (2001) Life Sci. , vol.69 , pp. 1471-1484
    • Klunk, W.E.1    Wang, Y.2    Huang, G.3    Debnath, M.L.4    Holt, D.P.5    Mathis, C.A.6
  • 25
    • 0030853702 scopus 로고    scopus 로고
    • Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles
    • J. Kreuter, V.E. Petrov, D.A. Kharkevich, and R.N. Alyautdin Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles J. Control. Release 49 1997 81 87
    • (1997) J. Control. Release , vol.49 , pp. 81-87
    • Kreuter, J.1    Petrov, V.E.2    Kharkevich, D.A.3    Alyautdin, R.N.4
  • 26
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • J. Kreuter Nanoparticulate systems for brain delivery of drugs Adv. Drug Deliv. Rev. 47 2001 65 81
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 27
    • 6344294066 scopus 로고    scopus 로고
    • Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
    • J. Kreuter Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain J. Nanosci. Nanotech. 4 2004 484 488
    • (2004) J. Nanosci. Nanotech. , vol.4 , pp. 484-488
    • Kreuter, J.1
  • 29
    • 0037335187 scopus 로고    scopus 로고
    • Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    • J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S.E. Gelperina, B. Engelhardt, R. Alyautdin, H. von Briesen, and D.J. Begley Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles Pharm. Res. 20 2003 409 416
    • (2003) Pharm. Res. , vol.20 , pp. 409-416
    • Kreuter, J.1    Ramge, P.2    Petrov, V.3    Hamm, S.4    Gelperina, S.E.5    Engelhardt, B.6    Alyautdin, R.7    Von Briesen, H.8    Begley, D.J.9
  • 30
    • 17044439021 scopus 로고    scopus 로고
    • Alzheimer's disease: Aβ, tau and synaptic dysfunction
    • F.M. LaFerla, and S. Oddo Alzheimer's disease: Aβ, tau and synaptic dysfunction Trends Mol. Med. 11 2005 170 176
    • (2005) Trends Mol. Med. , vol.11 , pp. 170-176
    • Laferla, F.M.1    Oddo, S.2
  • 31
    • 0141765877 scopus 로고    scopus 로고
    • Small-scale systems for in vivo drug delivery
    • D.L. LaVan, T. McGuire, and R. Langer Small-scale systems for in vivo drug delivery Nat. Biotechnol. 21 2003 1184 1191
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1184-1191
    • Lavan, D.L.1    McGuire, T.2    Langer, R.3
  • 32
    • 11944265265 scopus 로고    scopus 로고
    • Nanoparticle surface charges alter blood-brain barrier integrity and permeability
    • P.R. Lockman, J.M. Koziara, R.J. Mumper, and D.D. Allen Nanoparticle surface charges alter blood-brain barrier integrity and permeability J. Drug Target. 12 2004 635 641
    • (2004) J. Drug Target. , vol.12 , pp. 635-641
    • Lockman, P.R.1    Koziara, J.M.2    Mumper, R.J.3    Allen, D.D.4
  • 33
    • 0036386073 scopus 로고    scopus 로고
    • Pathological peptide folding in Alzheimer's disease and other conformational disorders
    • P.P. Mager, B. Penke, R. Walter, T. Harkany, and W. Härtig Pathological peptide folding in Alzheimer's disease and other conformational disorders Curr. Med. Chem. 9 2002 1763 1780
    • (2002) Curr. Med. Chem. , vol.9 , pp. 1763-1780
    • Mager, P.P.1    Penke, B.2    Walter, R.3    Harkany, T.4    Härtig, W.5
  • 34
    • 2342446265 scopus 로고    scopus 로고
    • Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
    • C.A. Mathis, Y. Wang, and W.E. Klunk Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain Curr. Pharm. Des. 10 2004 1469 1492
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 1469-1492
    • Mathis, C.A.1    Wang, Y.2    Klunk, W.E.3
  • 37
    • 0025124073 scopus 로고
    • In vitro model for the degradation of alkylcyanoacrylate nanoparticles
    • R.H. Müller, C. Lherm, J. Herbort, and P. Couvreur In vitro model for the degradation of alkylcyanoacrylate nanoparticles Biomaterials 11 1990 590 595
    • (1990) Biomaterials , vol.11 , pp. 590-595
    • Müller, R.H.1    Lherm, C.2    Herbort, J.3    Couvreur, P.4
  • 41
    • 13544275572 scopus 로고    scopus 로고
    • An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells
    • I. Sauer, I.R. Dunay, K. Weisgraber, M. Bienert, and M. Dathe An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells Biochemistry 44 2005 2021 2029
    • (2005) Biochemistry , vol.44 , pp. 2021-2029
    • Sauer, I.1    Dunay, I.R.2    Weisgraber, K.3    Bienert, M.4    Dathe, M.5
  • 42
    • 20044383377 scopus 로고    scopus 로고
    • Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities
    • A. Savonenko, G.M. Xu, T. Melnikova, J.L. Morton, V. Gonzales, M.P. Wong, D.L. Price, F. Tang, A.L. Markowska, and D.R. Borchelt Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to β-amyloid deposition and neurotransmitter abnormalities Neurobiol. Dis. 18 2005 602 617
    • (2005) Neurobiol. Dis. , vol.18 , pp. 602-617
    • Savonenko, A.1    Xu, G.M.2    Melnikova, T.3    Morton, J.L.4    Gonzales, V.5    Wong, M.P.6    Price, D.L.7    Tang, F.8    Markowska, A.L.9    Borchelt, D.R.10
  • 43
    • 0033022410 scopus 로고    scopus 로고
    • Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue
    • S.A. Schnell, W.A. Staines, and M.W. Wessendorf Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue J. Histochem. Cytochem. 47 1999 719 730
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 719-730
    • Schnell, S.A.1    Staines, W.A.2    Wessendorf, M.W.3
  • 44
    • 0031765572 scopus 로고    scopus 로고
    • Nanoparticle technology for delivery of drugs across the blood-brain barrier
    • U. Schroeder, P. Sommerfeld, S. Ulrich, and B.A. Sabel Nanoparticle technology for delivery of drugs across the blood-brain barrier J. Pharm. Sci. 87 1998 1305 1307
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1305-1307
    • Schroeder, U.1    Sommerfeld, P.2    Ulrich, S.3    Sabel, B.A.4
  • 45
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins and therapy
    • D.J. Selkoe Alzheimer's disease: genes, proteins and therapy Phys. Rev. 81 2001 741 766
    • (2001) Phys. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 47
    • 0033982176 scopus 로고    scopus 로고
    • Long-term stability of PBCA nanoparticle suspensions
    • P. Sommerfeld, B.A. Sabel, and U. Schroeder Long-term stability of PBCA nanoparticle suspensions J. Microencapsul. 17 2000 69 79
    • (2000) J. Microencapsul. , vol.17 , pp. 69-79
    • Sommerfeld, P.1    Sabel, B.A.2    Schroeder, U.3
  • 50
    • 1642389168 scopus 로고    scopus 로고
    • In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles
    • C.O. Sullivan, and C. Birkinshaw In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles Biomaterials 25 2004 4375 4382
    • (2004) Biomaterials , vol.25 , pp. 4375-4382
    • Sullivan, C.O.1    Birkinshaw, C.2
  • 51
    • 7044220336 scopus 로고    scopus 로고
    • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
    • J. Tsai, J. Grutzendler, K. Duff, and W.B. Gan Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches Nat. Neurosci. 7 2004 1181 1183
    • (2004) Nat. Neurosci. , vol.7 , pp. 1181-1183
    • Tsai, J.1    Grutzendler, J.2    Duff, K.3    Gan, W.B.4
  • 52
    • 0033526179 scopus 로고    scopus 로고
    • Carrier-mediated or specialized transport of drugs across the blood-brain barrier
    • A. Tsuji, and I. Tamai Carrier-mediated or specialized transport of drugs across the blood-brain barrier Adv. Drug Deliv. Rev. 36 1999 277 290
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , pp. 277-290
    • Tsuji, A.1    Tamai, I.2
  • 53
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: Crossing cellular barriers
    • P.L. Tuma, and A.L. Hubbard Transcytosis: crossing cellular barriers Physiol. Rev. 83 2003 871 932
    • (2003) Physiol. Rev. , vol.83 , pp. 871-932
    • Tuma, P.L.1    Hubbard, A.L.2
  • 55
    • 0346848902 scopus 로고    scopus 로고
    • Gender differences in the amount and deposition of amyloid β in APPswe and PS1 double transgenic mice
    • J. Wang, H. Tanila, J. Puoliväli, I. Kadish, and T. van Groen Gender differences in the amount and deposition of amyloid β in APPswe and PS1 double transgenic mice Neurobiol. Dis. 14 2003 318 327
    • (2003) Neurobiol. Dis. , vol.14 , pp. 318-327
    • Wang, J.1    Tanila, H.2    Puoliväli, J.3    Kadish, I.4    Van Groen, T.5
  • 56
    • 5044224056 scopus 로고    scopus 로고
    • Delivery systems for small molecule drugs, proteins, and DNA: The neuroscience/biomaterial interface
    • K.J. Whittlesey, and L.D. Shea Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface Exp. Neurol. 190 2004 1 16
    • (2004) Exp. Neurol. , vol.190 , pp. 1-16
    • Whittlesey, K.J.1    Shea, L.D.2
  • 57
    • 16344368162 scopus 로고    scopus 로고
    • Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
    • H. Wolburg, K. Wolburg-Buchholz, and B. Engelhardt Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact Acta Neuropathol. 109 2005 181 190
    • (2005) Acta Neuropathol. , vol.109 , pp. 181-190
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Engelhardt, B.3


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