Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease

Journal of Biological Chemistry

Volumn 278, Issue 16, 2003, Pages 13905-13911

  Adessi, Céline ^a   Frossard, Marie José ^a   Boissard, Christophe ^b   Fraga, Santiago ^a   Bieler, Sylvain ^a   Ruckle, Thomas ^a   Vilbois, Francis ^a   Robinson, Sandra M ^c   Mutter, Manfred ^b   Banks, William A ^c   Soto, Claudio ^a  

^a SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^b EPFL   (Switzerland)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; PHARMACODYNAMICS; POLYPEPTIDES;

PATHOGENESIS;

DRUG PRODUCTS;

ACETYLLEUCYLPROLYLPHENYLALANYLPHENYLALANYLASPARTYL DERIVATIVE; AMYLOID BETA PROTEIN; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CARBON; IABETA5 PEPTIDE; LEAD; LIGAND; PEPTIDE; PEPTIDE FRAGMENT; TRITIUM;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG ACTIVITY; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; BRAIN; CHEMICAL MODEL; CHEMISTRY; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; PEPTIDE SYNTHESIS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TIME;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; BLOOD-BRAIN BARRIER; BRAIN; CARBON; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; KINETICS; LEAD; LIGANDS; MICE; MODELS, CHEMICAL; PEPTIDE BIOSYNTHESIS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRITIUM;

EID: 0038529679     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211976200     Document Type: Article

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