Antiviral innate immunity pathways

Cell Research

Volumn 16, Issue 2, 2006, Pages 141-147

  Seth, Rashu B ^a   Sun, Lijun ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Interferon; IRF; MAVS; Mitochondria; NF B; RIG I; Toll like receptor

Indexed keywords

DDX58 PROTEIN, MOUSE; DEAD BOX PROTEIN; INTERFERON; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR; VISA PROTEIN, MOUSE;

ANIMAL; BIOLOGICAL MODEL; CONFERENCE PAPER; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PATHOGENICITY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DEAD-BOX RNA HELICASES; IMMUNITY, INNATE; IMMUNITY, NATURAL; INTERFERON TYPE I; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VIRUSES;

HEPATITIS C VIRUS;

EID: 32644456874     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/sj.cr.7310019     Document Type: Conference Paper

References (35)

1. Honda K, Yanai H, Takaoka A, Taniguchi T. Regulation of the type IIFN induction: a current view. Int Immunol 2005; 17:1367-78.
2. Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296:298-300.
3. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511.
4. Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5:730-7.
5. Maniatis T, Falvo JV, Kim TH, et al. Structure and function of the interferon-beta enhanceosome. Cold Spring Harb Symp Quant Biol 1998; 63:609-620.
6. Silverman N, Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 2001; 15:2321-42.
7. Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003; 4:491-6.
8. Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-51.
9. Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005; 434:772-7.
10. Takaoka A, Yanai H, Kondo S, et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 2005; 434:243-9.
11. Deng L, Wang C, Spencer E, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103:351-61.
12. Wang C, Deng L, Hong M, et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001; 412:346-351.
13. Hacker H, Redecke V, Blagoev B, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 2005 [ Epub ahead of print].
14. Oganesyan G, Saha SK, Guo B, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2005 [Epub ahead of print].
15. Honda K, Ohba Y, Yanai H, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005; 434:1035-40.
16. Honda K, Yanai H, Mizutani T, et al. Role of a transductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A 2004; 101:15416-21.
17. Kawai T, Sato S, Ishii KJ, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004; 5:1061-8.
18. Uematsu S, Sato S, Yamamoto M, et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med 2005; 201:915-23.
19. O'Neill, L. A. Immunology. After the toll rush. Science 2004; 303:1481-2.
20. Kato H, Sato S, Yoneyama M, et al. Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity 2005; 23:19-28.
21. Yang K, Puel A, Zhang S, et al. Human TLR-7-, -8-, and -9-Mediated Induction of IFN-alpha/beta and -lambda Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses. Immunity 2005; 23:465-78.
22. Rothenfusser S, Goutagny N, DiPerna G, et al. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol 2005; 175:5260-8.
23. Yoneyama M, Kikuchi M, Matsumoto K, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005; 175:2851-8.
24. Andrejeva J, Childs KS, Young DF, et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A 2004; 101:17264-9.
25. Seth RB, Sun L, Ea CK, Chen ZJ. Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-kappaB and IRF3. Cell 2005; 122:669-82.
26. Kawai T, Takahashi K, Sato S, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6:981-8.
27. Xu LG, Wang YY, Han KJ, et al. VISA Is an Adapter Protein Required for Virus-Triggered IFN-beta Signaling. Mol Cell 2005; 19:727-40.
28. Meylan E, Curran J, Hofmann K, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005; 437:1167-72.
29. Gohda J, Matsumura T, Inoue J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. J Immunol 2004; 173:2913-7.
30. Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA. Rip 1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa} B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem 2005; 280:36560-6.
31. Lindenbach BD, Rice CM. Unravelling hepatitis C virus replication from genome to function. Nature 2005; 436:933-8.
32. Breiman A, Grandvaux N, Lin R, et al. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol 2005; 79:3969-78.
33. Foy E, Li K, Sumpter R Jr, et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A 2005; 102:2986-91.
34. Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300:1145-8.
35. Li XD, Sun L, Seth RB, Pineda G, Chen ZJ. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A 2005; 102:17717-22.