Structural determinants and molecular mechanism for the resistance of HIV-1 RT to nucleoside analogues

Current Drug Metabolism

Volumn 5, Issue 4, 2004, Pages 305-316

  Deval, J ^a   Courcambeck, J ^b   Selmi, B ^a   Boretto, J ^a   Canard, Bruno ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Genoscience   (France)

Author keywords

Crystal structure; Discrimination; Drug resistance; HIV 1; Molecular mechanism; Nucleoside; Pyrophosphorolysis; Reverse transcriptase

Indexed keywords

ABACAVIR; ARGININE; DIDANOSINE; DNA; DNA POLYMERASE; EMTRICITABINE; FOSCARNET; GLYCINE; LAMIVUDINE; LEUCINE; LYSINE; METHIONINE; NUCLEOTIDE; POL PROTEIN; RNA; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; THREONINE; VALINE; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DNA REPAIR; DNA SYNTHESIS; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; EXCISION REPAIR; GENE MUTATION; HOST; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LICENCE; MOLECULAR MECHANICS; MOLECULAR MODEL; MULTIDRUG RESISTANCE; NONHUMAN; POLYMERIZATION; REVIEW; VIRUS DNA CELL DNA INTERACTION; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; PYRIMIDINE NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3242879168     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200043335478     Document Type: Review

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