The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using α-boranophosphate nucleotide analogues

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 42097-42104

  Deval, Jérôme ^a   Selmi, Boulbaba ^a   Boretto, Joëlle ^a   Egloff, Marie Pierre ^a   Guerreiro, Catherine ^a   Sarfati, Simon ^a   Canard, Bruno ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG DOSAGE; PATIENT TREATMENT; PHOSPHATES; RATE CONSTANTS; VIRUSES;

RESISTANCE;

ENZYMES;

2',3' DIDEOXYADENINE 5' TRIPHOSPHATE; 2',3' DIDEOXYCYTIDINE 5' TRIPHOSPHATE; ADENINE DERIVATIVE; ALPHA BORANOPHOSPHATE; BORANE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PRIMER DNA; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE 5' TRIPHOSPHATE;

ARTICLE; BINDING AFFINITY; CATALYSIS; DNA REPAIR; DRUG SELECTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR MODEL; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; STEADY STATE; VIRUS INHIBITION;

ANTI-HIV AGENTS; DEOXYADENINE NUCLEOTIDES; DRUG RESISTANCE, MULTIPLE; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; THYMINE NUCLEOTIDES; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0036829992     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206725200     Document Type: Article

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