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Volumn 44, Issue 3, 2000, Pages 568-573

A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; ISOLEUCINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE; VALINE; ZIDOVUDINE;

EID: 17544391491     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.3.568-573.2000     Document Type: Article
Times cited : (117)

References (29)
  • 1
    • 0027373308 scopus 로고
    • High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase
    • Boucher, C. A. B., N. Cammack, P. Schipper, R. Schuurman, P. Rouse, M. A. Wainberg, and J. M. Cameron. 1993. High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 37:2231-2234.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 2231-2234
    • Boucher, C.A.B.1    Cammack, N.2    Schipper, P.3    Schuurman, R.4    Rouse, P.5    Wainberg, M.A.6    Cameron, J.M.7
  • 2
  • 4
    • 0028057581 scopus 로고
    • Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine
    • Gu, Z., Q. Gao, H. Fang, H. Salomon, M. A. Partiak, E. Goldberg, J. Cameron, and M. A. Wainberg. 1994. Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine. Antimicrob. Agents Chemother. 38:275-281.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 275-281
    • Gu, Z.1    Gao, Q.2    Fang, H.3    Salomon, H.4    Partiak, M.A.5    Goldberg, E.6    Cameron, J.7    Wainberg, M.A.8
  • 5
    • 0028034266 scopus 로고
    • The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro
    • Gu, Z., R. S. Fletcher, E. J. Arts, M. A. Wainberg, and M. A. Parniak. 1994. The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. J. Biol. Chem. 269:28118-28122.
    • (1994) J. Biol. Chem. , vol.269 , pp. 28118-28122
    • Gu, Z.1    Fletcher, R.S.2    Arts, E.J.3    Wainberg, M.A.4    Parniak, M.A.5
  • 6
    • 0029843986 scopus 로고    scopus 로고
    • Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility
    • Harrigan, P. R., I. Kinghorn, S. Bloor, S. D. Kemp, I. Nájera, A. Kohli, and B. A. Larder. 1996. Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility. J. Virol. 70:5930-5934.
    • (1996) J. Virol. , vol.70 , pp. 5930-5934
    • Harrigan, P.R.1    Kinghorn, I.2    Bloor, S.3    Kemp, S.D.4    Nájera, I.5    Kohli, A.6    Larder, B.A.7
  • 8
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
    • Huang, H., R. Chopra, G. L. Verdine, and S. C. Harrison. 1998. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282:1669-1675.
    • (1998) Science , vol.282 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Verdine, G.L.3    Harrison, S.C.4
  • 9
    • 0030048748 scopus 로고    scopus 로고
    • Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy
    • Iversen, A. K., R. W. Shafer, K. Wehrly, M. A. Winters, J. Mullins, B. Cheseboro, and T. C. Merigan. 1996. Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy. J. Virol. 70:1086-1090.
    • (1996) J. Virol. , vol.70 , pp. 1086-1090
    • Iversen, A.K.1    Shafer, R.W.2    Wehrly, K.3    Winters, M.A.4    Mullins, J.5    Cheseboro, B.6    Merigan, T.C.7
  • 10
    • 0029824426 scopus 로고    scopus 로고
    • In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: Mutations, kinetics, and frequencies
    • Jacobsen, H., M. Hänggi, M. Ott, I. B. Duncan, S. Owen, M. Andreoni, S. Vella, and J. Mous. 1996. In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics, and frequencies. J. Infect. Dis. 173:1379-1387.
    • (1996) J. Infect. Dis. , vol.173 , pp. 1379-1387
    • Jacobsen, H.1    Hänggi, M.2    Ott, M.3    Duncan, I.B.4    Owen, S.5    Andreoni, M.6    Vella, S.7    Mous, J.8
  • 11
    • 0028085161 scopus 로고
    • Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates
    • Kellam, P., and B. A. Larder. 1994. Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 38:23-30.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 23-30
    • Kellam, P.1    Larder, B.A.2
  • 12
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • Kellam, P., C. A. B. Boucher, and B. A. Larder. 1992. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc. Natl. Acad. Sci. USA 89:1934-1938.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1934-1938
    • Kellam, P.1    Boucher, C.A.B.2    Larder, B.A.3
  • 13
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder, B. A., and S. D. Kemp. 1989. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246: 1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 14
    • 0029028067 scopus 로고
    • Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
    • Larder, B. A., S. D. Kemp, and P. R. Harrigan. 1995. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 269:696-699.
    • (1995) Science , vol.269 , pp. 696-699
    • Larder, B.A.1    Kemp, S.D.2    Harrigan, P.R.3
  • 15
    • 0345486993 scopus 로고    scopus 로고
    • Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride
    • Miller, V., M.-P. de Béthune, A. Kober, M. Stürmer, K. Hertogs, R. Pauwels, P. Stoffels, and S. Staszewski. 1998. Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride. Antimicrob. Agents Chemother. 42:3123-3129.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3123-3129
    • Miller, V.1    De Béthune, M.-P.2    Kober, A.3    Stürmer, M.4    Hertogs, K.5    Pauwels, R.6    Stoffels, P.7    Staszewski, S.8
  • 16
  • 17
    • 4244124413 scopus 로고    scopus 로고
    • A novel geno-type encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers cross-resistance to NRTIs
    • Rakik, A., M. Ait-Khaled, P. Griffin, D. Thomas, J.-P. Kleim, and M. Tisdale, for the Abacavir CNA2007 International Study Group. 1998. A novel geno-type encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers cross-resistance to NRTIs. AIDS 12(Suppl. 4):S25.
    • (1998) AIDS , vol.12 , Issue.4 SUPPL.
    • Rakik, A.1    Ait-Khaled, M.2    Griffin, P.3    Thomas, D.4    Kleim, J.-P.5    Tisdale, M.6
  • 19
    • 0025082210 scopus 로고
    • Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus
    • Richman, D. D., J. M. Grimes, and S. W. Lagakos. 1990. Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus. J. Acquir. Immune Defic. Syndr. 3:743-746.
    • (1990) J. Acquir. Immune Defic. Syndr. , vol.3 , pp. 743-746
    • Richman, D.D.1    Grimes, J.M.2    Lagakos, S.W.3
  • 21
    • 0030012398 scopus 로고    scopus 로고
    • Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538)
    • Schmit, J.-C., L. Ruiz, B. Clotet, A. Raventos, J. Tor, J. Leonard, J. Desmyter, E. De Clercq, and A.-M. Vandamme. 1996. Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538). AIDS 10:995-999.
    • (1996) AIDS , vol.10 , pp. 995-999
    • Schmit, J.-C.1    Ruiz, L.2    Clotet, B.3    Raventos, A.4    Tor, J.5    Leonard, J.6    Desmyter, J.7    De Clercq, E.8    Vandamme, A.-M.9
  • 23
    • 0029007143 scopus 로고
    • Drug resistance and heterogeneous long-term virologie responses of human immunodeficiency virus type 1-infected subjects to zidovudine and didanosine combination therapy. The AIDS Clinical Trials Group 143 Virology Team
    • Shafer, R. W., A. K. Iversen, M. A. Winters, E. Aguiniga, D. A. Katzenstein, and T. C. Merigan. 1995. Drug resistance and heterogeneous long-term virologie responses of human immunodeficiency virus type 1-infected subjects to zidovudine and didanosine combination therapy. The AIDS Clinical Trials Group 143 Virology Team. J. Infect. Dis. 172:70-78.
    • (1995) J. Infect. Dis. , vol.172 , pp. 70-78
    • Shafer, R.W.1    Iversen, A.K.2    Winters, M.A.3    Aguiniga, E.4    Katzenstein, D.A.5    Merigan, T.C.6
  • 25
    • 0027398296 scopus 로고
    • Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: An in vitro comparative study
    • Shirasaka, T., R. Yarchoan, M. O'Brien, R. Husson, B. Anderson, E. Kojima, S. Broder, and H. Mitsuya. 1993. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc. Natl. Acad. Sci. USA 90:562-566.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 562-566
    • Shirasaka, T.1    Yarchoan, R.2    O'Brien, M.3    Husson, R.4    Anderson, B.5    Kojima, E.6    Broder, S.7    Mitsuya, H.8
  • 26
    • 26544471669 scopus 로고    scopus 로고
    • Reduced nucleoside analogue susceptibility patterns and correlation with proportion of mutant virus detected by differential hybridization in patients receiving AZT and ddI
    • Skowron, G., C. Petropoulos, M. Holodniy, M. Wesley, L. Ferrigno, and K. Frost for the American Foundation for AIDS Research Community Based Clinical Trials Network, New York, NY, USA. 1998. Reduced nucleoside analogue susceptibility patterns and correlation with proportion of mutant virus detected by differential hybridization in patients receiving AZT and ddI. AIDS 12(Suppl. 4):S19.
    • (1998) AIDS , vol.12 , Issue.4 SUPPL.
    • Skowron, G.1    Petropoulos, C.2    Holodniy, M.3    Wesley, M.4    Ferrigno, L.5    Frost, K.6
  • 28
    • 0027285372 scopus 로고
    • Rapid in vitro selection of human immunodeficiency type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • Tisdale, M., S. D. Kemp, N. R. Parry, and B. A. Larder. 1993. Rapid in vitro selection of human immunodeficiency type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. USA 90:5653-5656.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.D.2    Parry, N.R.3    Larder, B.A.4
  • 29
    • 0032533207 scopus 로고    scopus 로고
    • A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors
    • Winters, M. A., K. L. Coolley, Y. A. Girard, D. J. Levee, H. Hamdan, R. W. Shafer, D. A. Katzenstein, and T. C. Merigan. 1998. A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. J. Clin. Invest. 102:1769-1775.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1769-1775
    • Winters, M.A.1    Coolley, K.L.2    Girard, Y.A.3    Levee, D.J.4    Hamdan, H.5    Shafer, R.W.6    Katzenstein, D.A.7    Merigan, T.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.