Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

Biochemistry

Volumn 38, Issue 29, 1999, Pages 9440-9448

  Feng, Joy Y ^a   Anderson, Karen S ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE; METHIONINE; MUTANT PROTEIN; RNA DIRECTED DNA POLYMERASE; VALINE; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA SYNTHESIS; DNA TEMPLATE; DRUG RESISTANCE; ENZYME MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; DEOXYCYTIDINE MONOPHOSPHATE; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA PRIMERS; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; LAMIVUDINE; RNA, VIRAL; TEMPLATES, GENETIC; THERMODYNAMICS; VALINE;

EID: 0033587620     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990709m     Document Type: Article

References (53)

1. Schinazi, R. F., Lloyd, R. M., Jr., Nguyen, M. H., Cannon, D. L., McMillan, A., Ilksoy, N., Chu, C. K., Liotta, D. C., Bazmi, H. Z., and Mellors, J. W. (1993) Antimicrob. Agents Chemother. 37, 875-881.
2. Schuurman, R., Nijhuis, M., van Leeuwen, R., Schipper, P., Collis, P., Danner, S. A., Mulder, J., Loveday, C., Christopherson, C., Kwok, S., Sninsky, J., and Boucher, C. A. B. (1995) J. Infect. Dis. 171, 1411-1419.
3. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Science 256, 1783-1790.
4. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6320-6324.
5. Huang, H., Verdine, G. L., Chopra, R., and Harrison, S. C. (1998) Science 282, 1669-1675.
6. Wakefield, J. K., Jablonski, S. A., and Morrow, C. D. (1992) J. Virol. 66, 6802-6812.
7. Boyer, P. L., and Hughes, S. (1995) Antimicrob. Agents Chemother. 39, 1624-1628.
8. Wainberg, M. A., Drosopoulos, W. C., Salomon, H., Hsu, M., Borkow, G., Parniak, M. A., Gu, Z., Song, Q., Manne, J., Islam, S., Castriota, G., and Prasad, V. R. (1996) Science 271, 1282-1285.
9. Back, N. K. T., Nijhui, M., Keulen, W., Boucher, C. A. B., Oude Essink, B. B., van Kuilenburg, A. B. P., van Gennip, A. H., and Berkhout, B. (1996) EMBO J. 15, 4040-4049.
10. Chao, S.-F., Chan, V.-L., Juranka, P., Kaplan, A. H., Swanstrom, R., and Hutchison, C. A. I. (1995) Nucleic Acids Res. 23, 803-810.
11. Pandey, V., Kaushik, N., Rege, N., Sarafianos, S. G., Yadav, P. N. S., and Modak, M. J. (1996) Biochemistry 35, 2168-2179.
12. Hsu, M., Inouye, P., Rezende, L., Richard, N., Li, Z., Prasad, V. R., and Wainberg, M. A. (1997) Nucleic Acids Res. 25, 4532-4536.
13. Eron, J. J., Benoit, S. L., Jemsek, J., MacArthur, R. D., Santana, J., Quinn, J. B., Kuritzkes, D. R., Fallon, M. A., and Rubin, M. (1995) N. Engl. J. Med. 333, 1662-1669.
14. Larder, B. A., Kemp, S. D., and Harrigan, P. R. (1995) Science 269, 696-699.
15. Wainberg, M. A. (1997) Leukemia 11 (Suppl. 3), 85-88.
16. Preston, B. D. (1997) Science 275, 228-229.
17. Larder, B. A., and Kemp, S. D. (1989) Science 246, 1155-1158.
18. Larder, B. A., Kellam, P., and Kemp, S. D. (1991) AIDS 5, 137-144.
19. Larder, B. A. (1994) J. Gen. Virol. 75, 951-957.
20. Kellam, P., Boucher, C. A., and Larder, B. A. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1934-1938.
21. Kati, W. M., Johnson, K. A., Jerva, L. F., and Anderson, K. S. (1992) J. Biol. Chem. 267, 25988-25997.
22. Spence, R. A., Anderson, K. S., and Johnson, K. A. (1995) Science 267, 988-993.
23. Kerr, S. G., and Anderson, K. S. (1997) Biochemistry 36, 14064-14070.
24. Vaccaro, J. A., and Anderson, K. S. (1998) Biochemistry 37, 14189-14194.
25. Hsieh, J. C., Zinnen, S., and Modrich, P. (1993) J. Biol. Chem. 268, 24607-24613.
26. Reardon, J. E. (1993) J. Biol. Chem. 268, 8743-8751.
27. Rittinger, K., Divita, G., and Goody, R. S. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8046-8049.
28. Krebs, R., Immendörfer, U., Thrall, S. H., Wöhrl, B. M., and Goody, R. S. (1997) Biochemistry 36, 10292-10300.
29. Faraj, A., Agrofoglio, L. A., Wakefield, J. K., McPherson, S., Morrow, C. D., Gosselin, G., Mathe, C., Imbach, J.-L., Schinazi, R. F., and Sommadossi, J.-P. (1994) Antimicrob. Agents Chemother. 38, 2300-2305.
30. Cherrington, J. M., Fuller, M. D., Mulato, A. S., Allen, S. J. W., Kunder, S. C., Ussery, M. A., Lesnikowski, Z., Schinazi, R. F., Sommadossi, J.-P., and Chen, M. S. (1996) Antimicrob. Agents Chemother. 40, 1270-1273.
31. Gray, N. M., Marr, C. L., Penn, C. R., Cameron, J. M., and Bethell, R. C. (1995) Biochem. Pharmacol. 50, 1043-1051.
32. Ueno, T., and Mitsuya, H. (1997) Biochemistry 36, 1092-1099.
33. Feng, J. Y., and Anderson, K. S. (1999) Biochemistry 38, 55-63.
34. Oude Essink, B. B., Back, N. K., and Berkhout, B. (1997) Nucleic Acids Res. 25, 3212-3217.
35. Rezende, L. F., Drosopoulos, W. C., and Prasad, V. R. (1998) Nucleic Acids Res. 26, 3066-3072.
36. Johnson, K. A. (1992) Enzymes (3rd Ed.) 20, 1-61.
37. Kerr, S. G., and Anderson, K. S. (1997) Biochemistry 36, 14056-14063.
38. Patel, P. H., and Preston, B. D. (1994) Proc. Natl. Acad. Sci. U.S.A 91, 549-553.
39. Thrall, S. H., Krebs, R., Wohrl, B. M., Cellai, L., Goody, R. S., and Restle, T. (1998) Biochemistry 37, 13349-13358.
40. Boucher, C. A., Cammack, N., Schipper, P., Schuurman, R., Rouse, P., Wainberg, M. A., and Cameron, J. M. (1993) Antimicrob. Agents Chemother. 37, 2231-2234.
41. Gao, Q., Gu, Z.-X., Parniak, M. A., Cameron, J., Cammack, N., Boucher, C., and Wainberg, M. A. (1993) Antimicrob. Agents Chemother. 37, 1390-1392.
42. Tisdale, M., Kemp, S. D., Parry, N. R., and Larder, B. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 5653-5656.
43. Doolittle, R. F., Feng, D.-F., Johnson, M. S., and McClure, M. A. (1989) Q. Rev. Biol. 64, 1-30.
44. McClure, M. A. (1993) in Reverse Transcriptase (Skalka, A. M., and Goff, S. P., Eds.) pp 425-444, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
45. Harris, D., Yadav, P. N. S., and Pandey, V. N. (1998) Biochemistry 37, 9630-9640.
46. Larder, B. A., Kemp, S. D., and Purifoy, D. J. M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4803-4807.
47. Preston, B. D., and Dougherty, J. P. (1996) Trends Microbiol. 4, 16-21.
48. Drosopoulos, W. C., Rezende, L. F., Wainberg, M. A., and Prasad, V. R. (1998) J. Mol. Med. 76, 604-612.
49. Bebenek, K., Abbotts, J., Roberts, J. D., Wilson, S. H., and Kunkel, T. A. (1989) J. Biol. Chem. 264, 16948-16956.
50. Hamburgh, M. E., Drosopoulos, W. C., and Prasad, V. R. (1998) Nucleic Acids Res. 26, 4389-4394.
51. Wainberg, M. A., Salomon, H., Gu, Z., Montaner, J. S. G., Cooley, T. P., McCaffrey, R., Ruedy, J., Hirst, H. M., Cammack, N., Cameron, J., and Nicholson, W. (1995) AIDS 9, 351-357.
52. Nijhuis, M., Schuurman, R., de Jong, D., van Leeuwen, R., Lange, J., Danner, S., Keulen, W., de Groot, T., and Boucher, C. A. B. (1997) J. Infect. Dis. 176, 398-405.
53. Skoog, D. A. (1985) in Principles of Instrumental Analysis, 3rd ed., pp 7-18, Saunders College Publishing, New York.