Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism

Annals of the New York Academy of Sciences

Volumn 777, Issue , 1996, Pages 146-157

  Roses, A D ^a   Einstein, G ^a   Gilbert, J ^a   Goedert, M ^b   Han, S H ^a   Huang, D ^a   Hulette, C ^a   Masliah, E ^c   Pericak Vance, M A ^a   Saunders, A M ^a   Schmechel, D E ^a   Strittmattter, W J ^a   Weisgraber, K H ^d   Xi, P T ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; APOLIPOPROTEIN E; BETA TUBULIN; MICROTUBULE ASSOCIATED PROTEIN; NERVE PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; CONGENITAL DISORDER; CYTOPLASM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IMMUNOELECTRON MICROSCOPY; MICROTUBULE; MICROTUBULE ASSEMBLY; NERVE CELL; NEUROFIBRILLARY TANGLE; ONSET AGE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENILE PLAQUE; STRESS;

EID: 0029923222     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb34413.x     Document Type: Conference Paper

References (36)

1. GOEDERT, M., C. M. WISCHIK, R. A. CROWTHER, et al. 1988. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. USA 85(11):4051-4055.
2. SELKOE, D. J. 1994. Alzheimer's disease: A central role for amyloid. J. Neuropathol. Exp. Neurol. 53:438-447.
3. SCHELLENBERG, G. D., T. D. BIRD, E. M. WIJSMAN, et al. 1992. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258:668-671.
4. GOATE, A., H. M. CHARTIER, M. MULLAN, et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease [see comments]. Nature 349(6311):704-706.
5. SHERRINGTON, R., E. I. ROGAEV, Y. LIANG, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
6. SAUNDERS, A. M., W. J. STRITTMATTER, D. SCHMECHEL, et al. 1993. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43(8):1467-1472.
7. STRITTMATTER, W. J., A. M. SAUNDERS, D. SCHMECHEL, et al. 1993. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90(5):1977-1981.
8. PERICAK, V. M., J. L. BEBOUT, P. J. GASKELL, et al. 1991. Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage. Am. J. Hum. Genet. 48(6):1034-1050.
9. CORDER, E. H., A. M. SAUNDERS, W. J. STRITTMATTER, et al. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families [see comments]. Science 261(5123):921-923.
10. CORDER, E. H., A. M. SAUNDERS, N. J. RISCH, et al. 1994. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7:180-184.
11. ROSES, A. D., W. J. STRITTMATTER, V. M. PERICAK, et al. 1994. Clinical application of apolipoprotein E genotyping to Alzheimer's disease [letter]. Lancet 343(8912):1564-1565.
12. BASUN, H., M. GRUT, B. WINBLAD, et al. 1995. Apolipoprotein epsilon 4 allele and disease progression in patients with late-onset Alzheimer's disease. Neurosci. Lett. 183:32-34.
13. NAMBA, Y., M. TOMONAGA, H. KAWASAKI, et al. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541(1):163-166.
14. WISNIEWSKI, T. & B. FRANGIONE. 1992. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135(2):235-238.
15. DIEDRICH, J., S. WIETGREFE, A. HAASE, et al. 1991. Identifying and mapping changes in gene expression involved in the neuropathology of scrapie and Alzheimer's disease. [Review]. Curr. Top. Microbiol. Immunol. 172(259):259-274.
16. HUANG, D. Y., M. GOEDERT, R. JAKES, et al. 1994. Isoform-specific interactions of apolipoprotein E with the microtubule associated protein MAP2c: Implications for Alzheimer's disease Neurosci. Lett. In press.
17. STRITTMATTER, W. J., K. H. WEISGRABER, M. GOEDERT, et al. 1994. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. [Review]. Exp. Neurol. 125(2):163-171.
18. LANNFELT, L., L. LILIUS, M. NASTASE, et al. 1994. Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease. Neurosci. Lett. 169(1-2):175-178.
19. ROSES, A. D. 1994. The Alzheimer diseases. In Current Neurology. S. H. Appel, Ed. 111-141. Chicago: Mosby-Year Book.
20. ROSES, A. D. 1994. Apolipoprotein E affects the rate of Alzheimer disease expression: β-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J. Neuropathol. Exp. Neurol. 53:429-437.
21. HAN, S.-H., G. EINSTEIN, K. H. WEISGRABER, et al. 1994. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: A light and electron microscopic study. J. Neuropathol. Exp. Neurol. 53:535-544.
22. HAN, S.-H., C. HULETTE, A. M. SAUNDERS, et al. 1994. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and age-matched controls. Exp. Neurol. 128:13-26.
23. POIRIER, J., A. BACCICHET, D. DEA, et al. 1993. Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neuroscience 55(1):81-90.
24. REBECK, G. W., J. S. REITER, D. K. STRICKLAND, et al. 1993. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11(4):575-580.
25. SAKAI, J., A. HOSHINO, S. TAKAHASHI, et al. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J. Biol. Chem. 269(3):2173-2182.
26. STRITTMATTER, W. J., A. M. SAUNDERS, M. GOEDERT, et al. 1994. Isoform-specific interactions of apolipoprotein E with tau and phosphorylated tau: Implications for Alzheimer disease. Proc. Natl. Acad. Sci. USA 91:11183-11186.
27. 262 phosphorylation. Neurosci. Lett. 192:209-212.
28. LEE, V. M., B. J. BALIN, L. J. OTVOS, et al. 1991. A68: A major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251(4994):675-678.
29. MANDELKOW, E. M., J. BIERNAT, G. DREWES, et al. 1993. Microtubule-associated protein tau, paired helical filaments, and phosphorylation [Review]. Ann. N.Y. Acad. Sci. 695(209):209-216.
30. HARADA, A., K. OGUCHI, S. OKABE, et al. 1995. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369(6480): 488-491.
31. MASLIAH, E., M. MALLORY, N. GE, et al. 1995. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp. Neurol. In press.
32. EINSTEIN, G., R. BURANOSKY & B. J. GRAIN. 1994. Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques. J. Neurosci. 14(8):5077-5088.
33. NICOLL, J. A. R., G. W. ROBERTS & D. I. GRAHAM. 1995. Apolipoprotein E e4 allele is associated with deposition of amyloid β-protein following head injury. Nature Med. 1:135-137.
34. ROSES, A. D. & A. M. SAUNDERS. 1995. Head injury, amyloid β and Alzheimer's disease. Nature Med. 1:603-604.
35. NEWMAN, M. F., N. D. CROUGHWELL, J. A. BLUMENTHAL, et al. 1995. Predictors of cognitive decline after cardiac operation. Ann. Thorac. Surg. 59: 1326-1330.
36. ALBERTS, M. J., C. GRAFFAGNINO, C. MCCLENNEY, et al. 1995. ApoE genotype and survival from intracerebral hemorrhage. Lancet 346:575.