A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome

Journal of Molecular Endocrinology

Volumn 32, Issue 3, 2004, Pages 719-775

  Cicatiello, Luigi ^a   Scafoglio, Claudio ^a   Altucci, Lucia ^a   Cancemi, Massimo ^a   Natoli, Guido ^a   Facchiano, Angelo ^b   Iazzetti, Giovanni ^c   Calogero, Raffaele ^d   Biglia, Nicoletta ^d   De Bortoli, Michele ^d,e   Sfiligoi, Christian ^e   Sismondi, Piero ^d,e   Bresciani, Francesco ^a   Weisz, Alessandro ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Inst di Scienze dell'Alimentazione   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e CANDIOLO CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ESTRADIOL; ESTROGEN;

BREAST CANCER; CANCER CELL; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME 17; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA MICROARRAY; GENE ACTIVATION; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; RNA SYNTHESIS; STATISTICAL ANALYSIS; UNINDEXED SEQUENCE;

BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH SUBSTANCES; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 3042792342     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0320719     Document Type: Review

References (63)

1. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X et al. 2000 Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403 503-511.
2. Altucci L, Addeo R, Cicatiello L, Dauvois S, Parker MG, Truss M, Beato M, Sica V, Bresciani F & Weisz A 1996 17β-Estradiol induces cyclin D1 gene, transcription, p36D1-p34 cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Oncogene 12 2315-2324.
3. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT et al. 2000 Gene ontology: tool for the unification of biolog. The Gene Ontology Consortium. Nature Genetics 25 25-29.
4. Barlund M, Monni O, Kononen J, Cornelison R, Torhorst J, Sauter G, Kallioniemi OP & Kallioniemi A 2000 Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. Cancer Research 60 5340-5344.
5. Blondel M & Mann C 1996 G2 cyclins are required for the degradation of G1 cyclins in yeast. Nature 384 279-282.
6. Bonapace IM, Addeo R, Altucci L, Cicatiello L, Bifulco M, Laezza C, Salzano S, Sica V, Bresciani F & Weisz A 1996 17β -Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. Oncogene 12 753-763.
7. Boncinelli E, Simeone A, Acampora D & Mavilio F 1991 HOX gene activation by retinoic acid. Trends in Genetics 7 329-334.
8. Bortoluzzi S, Rampoldi L, Simionati B, Zimbello R, Barbon A, d'Alessi F, Tiso N, Pallavicini A, Toppo S, Cannata N et al. 1998 A comprehensive, high-resolution genomic transcript map of human skeletal muscle. Genome Research 8 817-825.
9. Bouras T, Southey MC, Chang AC, Reddel RR, Willhite D, Glynne R, Henderson MA, Armes JE & Venter DJ 2002 Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Research 62 1289-1295.
10. Caron H, van Schaik B, van der Mee M, Baas F, Riggins G, van Sluis P, Hermus MC, van Asperen R, Boon K, Voute PA et al. 2001 The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 291 1289-1292.
11. Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC & Aldaz CM 2000 Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Research 60 5977-5983.
12. Choi I, Gudas LJ & Katzenellenbogen BS 2000 Regulation of keratin 19 gene expression by estrogen in human breast cancer cells and identification of the estrogen responsive gene, region. Molecular and Cellular Endocrinology 164 225-237.
13. Cicatiello L, Addeo R, Altucci L, Belsito Petrizzi V, Boccia V, Cancemi M, Germano D, Pacilio C, Salzano S, Bresciani F et al. 2000 The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion. Molecular and Cellular Endocrinology 165 199-209.
14. Cohen BA, Mitra RD, Hughes JD & Church GM 2000 A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nature Genetics 26 183-186.
15. Couillard S, Labrie C, Gauthier S, Merand Y, Singh SM, Candas B & Labrie F 2000 Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in once mice. International Journal of Cancer 85 424-429.
16. Dekker J 2003 A closer look at long-range chromosomal interactions. Trends in Biochemical Sciences 28 277 280.
17. Draghici S, Khatri P, Martins RP, Ostermeier GC & Krawetz SA 2003 Global functional profiling of gene expression. Genomics 81 98-104.
18. Dudoit S, Yang YH, Callow MJ & Speed TP 2001 Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments. Technical report #578. http://www.stat.berkeley.edu/users/terry/zarray/Html/matt.html.
19. Eisen MB, Spellman PT, Brown PO & Botstein D 1998 Cluster analysis and display of genome-wide expression patterns. PNAS 95 14863-14868.
20. Fambrough D, McClure K, Kazlauskas A & Lander ES 1999 Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97 727 741.
21. Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ et al. 2001 Rerg is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Journal of Biological Chemistry 276 42259-42267.
22. Forozan F, Mahlamaki EH, Monni O, Chen Y, Veldman R, Jiang Y, Gooden GC, Ethier SP, Kallioniemi A & Kallioniemi OP 2000 Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Research 60 4519-4525.
23. Frasor J, Danes JM, Komm B, Chang K, Lyttle CR & Katzenellenbogen BS 2003 Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144 4562-4574.
24. Gene Expression Group web site: http://crisceb.unina2.it/geneexpression/
25. Hedenfalk I, Duggan D, Chen Y, Radmacher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP et al. 2001 Gene-expression profiles in hereditary breast cancer. New England Journal of Medicine 344 539-548.
26. Heid CA, Stevens J, Livak KJ & Williams PM 1994 Real time quantitative PCR. Genome Research 6 986-994.
27. Hodges LC, Cook JD, Lobenhofer EK, Li L, Bennett L, Bushel PR, Aldaz CM, Afshari CA & Walker CL 2003 Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Molecular Cancer Research 1 300-311.
28. Horne MC, Donaldson KL, Goolsby GL, Tran D, Mulheisen M, Hell JW & Wahl AF 1997 Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. Journal of Biological Chemistry 272 12650-12661.
29. Inoue A, Yoshida N, Omoto Y, Oguchi S, Yamori T, Kiyama R & Hayashi S 2002 Development of cDNA microarray for expression profiling of estrogen-responsive genes. Journal of Molecular Endocrinology 29 175-192.
30. Inoue S, Orimo A, Matsuda Y, Inazawa J, Emi M, Nakamura Y, Hori T & Muramatsu M 1995 Chromosome mapping of human (ZNF147) and mouse genes tor estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics 25 581-583.
31. Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson J Jr, Boguski MS et al. 1999 The transcriptional program in the response of human fibroblasts to serum. Science 283 83-87.
32. de Jager T, T, Mueller-Botz S, Imam A, Muck J & Neyses L 2001 Mechanisms of estrogen receptor action in the myocardium: rapid gene activation via the ERK1/2 pathway and serum response elements. Journal of Biological Chemistry 276 27873-27880.
33. Katoh M 2003 Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells. International Journal of Oncology 22 209-212.
34. Kelly MJ & Levin ER 2001 Rapid actions of plasma membrane estrogen receptors. Trends in Endocrinology and Metabolism 12 152-156.
35. Kudoh M, Knee DA, Takayama S & Reed JC 2002 Bag1 proteins regulate growth and survival of ZR-75-71 human breast cancer cells. Cancer Research 62 1904-1909.
36. Kyprianou N, English HF, Davidson NE & Isaacs JT 1991 Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Research 51 162-166.
37. Lercher MJ, Urrutia AO & Hurst LD 2002 Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nature Genetics 31 180-183.
38. Liu HL, Golder-Novoselsky E, Seto MH, Webster L, McClary J & Zajchowski DA 1998 The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant. Molecular Endocrinology 12 1733-1748.
39. Lobenhofer EK, Bennett L, Cable PL, Li L, Bushel PR & Afshari CA 2002 Regulation of DNA replication fork genes by 17 beta-estradiol. Molecular Endocrinology 16 1215-1229.
40. Moggs JG & Orphanides G 2001 Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Reports 2 775-781.
41. Monni O, Barlund M, Mousses S, Kononen J, Sauter G, Heiskanen M, Paavola P, Avela K, Chen Y, Bittner ML et al. 2001 Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer. PNAS 98 5711-5716.
42. Murayama Y, Hammond GL & Sugihara K 1999 The shbg gene and hormone dependence of breast cancer: a novel mechanism of hormone dependence of MCF-7 human breast cancer cells based upon SHBG. Breast Cancer 6 338-343.
43. Nye AC, Rajendran RR, Stenoien DL, Mancini MA, Katzenellenbogen BS & Belmont AS 2002 Alteration of large-scale chromatin structure by estrogen receptor. Molecular and Cellular Biology 22 3437-3449.
44. Oliver B, Parisi M & Clark D 2002 Gene expression neighborhoods. Journal of Biology 1 4.1-4.3.
45. Pawson T & Saxton TM 1999 Signaling networks do all roads lead to the same genes? Cell 97 675-678.
46. Perillo B, Sasso A, Abbondanza C & Palumbo G 2000 17β-Estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Molecular and Cellular Biology 20 2890-2901.
47. Perissi V, Menini N, Cottone E, Capello D, Sacco M, Montaldo F & De Bortoli M 2000 AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen. Oncogene 19 280-288.
48. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA et al. 2000 Molecular portraits of human breast tumours. Nature 406 747-752.
49. Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R & Safe S 2002 Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology 16 1793-1809.
50. Reik W & Walter J 2001 Genomic imprinting: parental influence on the genome. Nature. Reviews. Genetics 2 21-32.
51. Schena M, Shalon D, Davis RW & Brown PO 1995 Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270 467-470.
52. Schofield PN, Joyce JA, Lam WK, Grandjean V, Ferguson-Smith A, Reik NV & Maher ER 2001 Genomic imprinting and cancer; new paradigms in the genetics of neoplasia. Toxicology Letters 120 151-160.
53. Seth P, Krop I, Porter D & Polyak K 2002 Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression). Oncogene 21 836-843.
54. Sorbello V, Fuso L, Sfiligoi C, Scafoglio C, Ponzone R, Biglia N, Weisz A, Sismondi P & De Bortoli M 2003 Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer. International Journal of Biological Markers 18 123-129.
55. Soulez M & Parker MG 2001 Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling. Journal of Molecular 27 259-274.
56. Spellman PT & Rubin GM 2002 Evidence for large domains of similarly expressed genes in the Drosophila genome. Journal of Biology 1 5.1 5.8.
57. Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES & Golub TR 1999 Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. PNAS 96 2907-2912.
58. Tusher VG, Tibshirani R & Chu R 2001 Significance analysis of microarrays applied to the ionizing radiation response. PNAS 98 5116-5121.
59. Weisz A, Basile W, Scafoglio C, Natoli G, Altucci L, Bresciani F, Facchiano A, Sismondi P, Cicatiello L & De Bortoli M 2003 Molecular identification of ERalpha-positive breast cancer cells by the expression profile of an intrinsic set of hormone regulated genes. Journal of Cellular Physiology (In Press).
60. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO et al. 2002 Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell 13 1977-2000.
61. Xu CF, Chambers JA & Solomon E 1997 Complex regulation of the BRCA1 gene. Journal of Biological Chemistry 272 20994-20997.
62. Yamada M, Yoshida M & Hashinaka K 1993 Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene. Journal of Biological Chemistry 268 13479-13485.
63. Yue H, Eastman PS, Wang BB, Minor J, Doctolero MH, Nuttall RL, Stack R, Becker JW, Montgomery JR, Vainer M et al. 2001 An evaluation of the performance of cDNA microarrays for detecting changes in global m RNA expression. Nucleic Acids Research 29 E41.1.