Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats

Journal of Nutrition

Volumn 135, Issue 12, 2005, Pages

  Hilakivi Clarke, Leena ^a   Olivo, Susan E ^a   Shajahan, Ayesha ^a   Khan, Galam ^a   Zhu, Yuelin ^a   Zwart, Alan ^a   Cho, Elizabeth ^a   Clarke, Robert ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

(n 3) polyunsaturated fatty acids; Mammary tumorigenesis; Prepubertal diet

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; BRCA1 PROTEIN; DNA; OMEGA 3 FATTY ACID; PROTEIN KINASE B;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CELL; CANCER RISK; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DIETARY INTAKE; DNA DAMAGE; DNA REPAIR; FISH; GENE EXPRESSION; HYPOTHESIS; MICROARRAY ANALYSIS; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PERINATAL PERIOD; PREPUBERTY; RAT; UPREGULATION;

ANIMALIA;

EID: 31544448547     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.12.2946s     Document Type: Conference Paper

References (102)

1. Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ, Minkin S. Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer. 2003;89:1672-85.
2. Smith-Warner SA, Spiegelman D, Adami H-O, Beeson WL, van den Brandt PA, Folsom AR, Frazer GE, Freudenheim JL, Goldbohm RA, et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. Int J Cancer. 2001;92:767-74.
3. Holmes MD, Hunter DJ, Colditz GA, Stampfer MJ, Hankinson SE, Speizer FE, Freudenheim JL, Goldbohm RA, Graham S, et al. Association of dietary intake of fat and fatty acids with risk of breast cancer. J Am Med Assoc. 1999;281:914-20.
4. Holmes MD, Schisterman EF, Spiegelman D, Hunter DJ, Willett WC. Re: Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. J Natl Cancer Inst. 1999;91:1511-2.
5. Hunter DJ, Spiegelman D, Adami HO, Beeson L, van den Brandt PA, Folsom AR, Fraser GE, Goldbohm RA, Graham S, et al. Cohort studies of fat intake and the risk of breast cancer - a pooled analysis. N Engl J Med. 1996;334:356-61.
6. Hunter DJ, Willett WC. Nutrition and breast cancer. Cancer Causes Control. 1996;7:56-68.
7. Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fibre in relation to risk of breast cancer. J Am Med Assoc. 1992;268:2037-44.
8. Carroll KK. Dietary fats and cancer. Am J Clin Nutr. 1991;53:1064-7.
9. Fay MP, Freedman LS, Clifford CK, Midthune DN. Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. Cancer Res. 1997;57:3979-88.
10. Hopkins GJ, Carroll KK. Relationship between amount and type of dietary fat in promotion of mammary carcinogenesis induced by 7,12-dimethylmenz(a) anthracene. J Natl Cancer Inst. 1979;62:1009-12.
11. Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonniere F, Body G, Le Floch O, Chajes V. N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer.2002; 98:78-83.
12. Kaizer L, Boyd NF, Kriukov V, Tritchler D. Fish consumption and breast cancer risk: an ecological study. Nutr Cancer. 1989;12:61-8.
13. Terry PD, Rohan TE, Wolk A. Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. Am J Clin Nutr. 2003;77:532-43.
14. Stripp C, Overvad K, Christensen J, Thomsen BL, Olsen A, Moller S, Tjonneland A. Fish intake is positively associated with breast cancer incidence rate. J Nutr. 2003;133:3664-9.
15. Rose DP, Connolly JM. Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice. J Natl Cancer Inst. 1993;85:1743-7.
16. Cohen LA, Chen-Backlund JY, Sepkovic DW, Sugie S. Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion. Lipids. 1993;28:449-56.
17. Sasaki T, Kobayashi Y, Shimizu J, Wada M, In'nami S, Kanke Y, Takita T. Effects of dietary n-3-to-n-6 polyunsaturated fatty acid ratio on mammary carcinogenesis in rats. Nutr Cancer. 1998;30:137-43.
18. Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter D, Colditz GA, Hankinson SE, Speizer FE, Willett WC. Birthweight as a risk factor for breast cancer. Lancet. 1996;348:1542-6.
19. Ahlgren M, Sorensen T, Wohlfahrt J, Haflidadottir A, Holst C, Melbye M. Birth weight and risk of breast cancer in a cohort of 106,504 women. Int J Cancer. 2003;107:997-1000.
20. McCormack VA, dos Santos Silva I, De Stavola BL, Mohsen R, Leon DA, Lithell HO. Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ. 2003;326:248-53.
21. Sanderson M, Williams M, Malone KE, Stanford JL, Emanuel I, White E, Moore DE. Perinatal factors and risk of breast cancer. Edidemiology. 1996;7:34-7.
22. Hilakivi-Clarke L, Forsen T, Eriksson JG, Luoto R, Osmond C, Barker DJP. Tallness and overweight during childhood have opposing effects on breast cancer risk. Br J Cancer. 2001;85:1680-4.
23. Ahlgren M, Melbye M, Wohlfahrt J, Sorensen TI. Growth patterns and the risk of breast cancer in women. N Engl J Med. 2004;351:1619-26.
24. Le Marchand L, Kolonel LN, Earle ME, Mi MP. Body size at different periods of life and breast cancer risk. Am J Epidemiol. 1998;128:137-52.
25. Magnusson C, Baron J, Persson I, Wolk A, Bergstrom R, Trichopoulos D, Adami HO. Body size in different periods of life and breast cancer risk in post-menopausal women. Int J Cancer. 1998;76:29-34.
26. Berkey CS, Frazier AL, Gardner JD, Colditz G. Adolescence and breast carcinoma risk. Cancer. 1999;85:2400-9.
27. Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ, Willett WC. Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res. 2005;7:R314-25.
28. van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152:514-27.
29. Weiderpass E, Braaten T, Magnusson C, Kumle M, Vainio H, Lund E, Adami HO. A prospective study of body size in different periods of life and risk of premenopausal breast cancer. Cancer Epidemiol Biomarkers Prev. 2004;13:1121-7.
30. Jonsson F, Wolk A, Pedersen NL, Lichtenstein P, Terry P, Ahlbom A, Feychting M. Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry. Int J Cancer. 2003;106:594-9.
31. Lahmann PH, Hoffmann K, Allen N, van Gils CH, Khaw KT, Tehard B, Berrino F, Tjonneland A, Bigaard J, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2004;111:762-71.
32. Kinnunen TI, Luoto R, Gissler M, Hemminki E, Hilakivi-Clarke L. Pregnancy weight gain and breast cancer risk. BMC Womens Health. 2004;4:7-16.
33. Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, Clarke R. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep. 1999;6:1089-95.
34. Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R, Elgavish A. Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate. J Nutr. 2002;132:552S-8.
35. Hilakivi-Clarke L, Onojafe I, Raygada M, Cho E, Skaar T, Russo I, Clarke R. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br J Cancer. 1999;80:1682-8.
36. Cohen LA, Zhao Z, Pittman BSJA. Effect of intact and isoflavonedepleted soy protein on NMU-induced rat mammary tumorigenesis. Carcinogenesis. 2000;21:929-35.
37. Ueda M, Niho N, Imai T, Shibutani M, Mitsumori K, Matsui T, Hirose M. Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats. Nutr Cancer. 2003;47:141-7.
38. Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis. 2002;23:1491-6.
39. Shu XO, Jin F, Dai Q, Wen W, Potter JD, Kushi LH, Ruan Z, Gao YT, Zheng W. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev. 2001;10:483-8.
40. Trock B, Butler LW, Clarke R, Hilakivi-Clarke L. Meta-analysis of soy intake and breast cancer risk. J Nutr. 2001;130:690-1.
41. Hilakivi-Clarke L, Cabanes A, Olivo S, Kerr L, Bouker KB, Clarke R. Do estrogens always increase breast cancer risk? J Steroid Biochem Mol Biol. 2002;80:163-74.
42. Hilakivi-Clarke L, Clarke R, Onojafe I, Raygada M, Cho E, Lippman ME. A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring. Proc. Natl. Acad. Sci. U S A. 1997;94:9372-7.
43. Cabanes A, Wang M, Olivo S, de Assis S, Gustafsson JA, Khan G, Hilakivi-Clarke L. Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis. 2004;25(5):741-8.
44. Hilakivi-Clarke L, Onojafe I, Raygada M, Cho E, Clarke R, Lippman M. Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy. J Natl Cancer Inst. 1996;88:1821-7.
45. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ. Comparative study of human and rat mammary tumorigenesis. Lab Invest. 1990;62:244-78.
46. Russo J, Russo IH. Toward a unified concept of mammary carcinogenesis. In: Aldaz MC, Gould MN, McLachlan J, Slaga TJ, editors. Progress in clinical and biological research. New York: Wiley-Liss; 1997. p. 1-16.
47. Olivo S, Hilakivi-Clarke L. Opposing effects of prepubertal low and high fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis. Carcinogenesis. 2005;26(9):1563-72.
48. Boyd NF, Martin LJ, Stone J, Greenberg C, Minkin S, Yaffe MJ. Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention. Curr Oncol Rep. 2001;3:314-21.
49. Byrne C, Schairer C, Wolfe J, Parekh N, Salane M, Brinton LA, Hoover R, Haile R. Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst. 1995;87:1622-9.
50. Byrne C, Schairer C, Brinton LA, Wolfe J, Parekh N, Salane M, Carter C, Hoover R. Effects of mammographic density and benign breast disease on breast cancer risk (United States). Cancer Causes Control. 2001;12:103-10.
51. McCormack VA, dos Santos Silva I, De Stavola BL, Perry N, Vinnicombe S, Swerdlow AJ, Hardy R, Kuh D. Life-course body size and perimenopausal mammographic parenchymal patterns in the MRC 1946 British birth cohort. Br J Cancer. 2003;89:852-9.
52. Williams TM, Lisanti MP. The Caveolin genes: from cell biology to medicine. Ann Med. 2004;36:584-95.
53. Li S, Seitz R, Lisanti MP. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo. J Biol Chem. 1996;271:3863-8.
54. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997;272:6525-33.
55. Zhang X, Shen P, Coleman M, Zou W, Loggie BW, Smith LM, Wang Z. Caveolin-1 down-regulation activates estrogen receptor alpha expression and leads to 17beta-estradiol-stimulated mammary tumorigenesis. Anticancer Res. 2005;25:369-75.
56. Colditz GA, Frazier AL. Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev. 1995;4:567-71.
57. Robsahm TE, Tretli S. Breast cancer incidence in food- vs non-food-producing areas in Norway: possible beneficial effects of World War II. Br J Cancer. 2002;86:362-6.
58. Dirx MJ, van den Brandt PA, Goldbohm RA, Lumey LH. Diet in adolescence and the risk of breast cancer: results of the Netherlands Cohort Study. Cancer Causes Control; 1999;10:189-99.
59. Michels KB, Ekbom A. Caloric restriction and incidence of breast cancer. J. Am. Med. Assoc. 2004;291:1226-30.
60. Luo J, Miller MW. Ethanol enhances erbB-mediated migration of human breast cancer cells in culture. Breast Cancer Res Treat. 2000;63:61-9.
61. Swerdlow AJ, De Stavola BL, Floderus B, Holm NV, Kaprio J, Verkasalo PK, Mack T. Risk factors for breast cancer at young ages in twins: an international population-based study. J Natl Cancer Inst. 2002;94:1238-46.
62. Frazier AL, Ryan CT, Rockett H, Willett WC, Colditz GA. Adolescent diet and risk of breast cancer. Breast Cancer Res. 2003;5:R59-64.
63. Hislop TG, Goldman AJ, Elwood JM, Brauer G, Kan L. Childhood and recent eating patterns and risk of breast cancer. Cancer Detect Prev. 1986;9:47-58.
64. Potischman N, Weiss HA, Swanson CA, Coates RJ, Gammon MD, Malone KE, Brogan D, Stanford JL, Hoover RN, Brinton LA. Diet during adolescence and risk of breast cancer among young women. J Nat Cancer Inst. 1998;90:226-63.
65. Baer HJ, Schnitt SJ, Connolly JL, Byrne C, Cho E, Willett WC, Golditz GA. Adolescent diet and incidence of proliferative benign breast disease. Cancer Epidemiol Biomarkers Prev. 2003;12:1159-67.
66. Pryor M, Slattery ML, Robinson LM, Egger M. Adolescent diet and breast cancer in Utah. Cancer Res. 1989;49:2161-7.
67. Pei RJ, Sato M, Yuri T, Danbara N, Nikaido Y, Tsubura A. Effect of prenatal and prepubertal genistein exposure on N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats. In Vivo. 2003;17:349-57.
68. Ward WE, Jiang FO, Thompson LU. Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures. Nutr Cancer. 2000;37:187-92.
69. Tou JC, Thompson LU. Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures. Carcinogenesis. 1999;20:1831-5.
70. Chen J, Tan KP, Ward WE, Thompson LU. Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. Exp Biol Med (Maywood). 2003;228:951-8.
71. Metz RP, Schedin P. Adolescent vitamin A intake alters susceptibility to mammary tumorigenesis in the Sprague Dawley rats. Nutr Cancer. 2002;42:78-90.
72. Huggins C, Grand LC, Brillantes FP. Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression. Nature. 1961;189:204-7.
73. Russo J, Russo IH. Biological and molecular bases of mammary carcinogenesis. Lab Invest. 1987;57:112-37.
74. Thompson HJ. Methods for the induction of mammary carcinogenesis in the rat using either 7,12-dimethylbenz[a]anthracene or 1-methyl-1-nitrourea. In: Ip MM, Asch BB, editors. Methods in mammary gland biology and breast cancer research. New York: Kluwer Academic; 2000. p. 19-29.
75. Bonner MR, Han D, Nie J, Rogerson P, Vena JE, Muti P, Trevisan M, Edge SB, Freudenheim JL. Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure. Cancer Epidemiol Biomarkers Prev. 2005;14:53-60.
76. Terry MB, Gammon MD, Zhang FF, Eng SM, Sagiv SK, Paykin AB, Wang Q, Hayes S, Teitelbaum SL, et al. Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2004;13:2053-8.
77. Hilakivi-Clarke L, Wang C, Kalil M, Riggins R, Pestell RG. Nutritional modulation of the cell cycle and breast cancer. Endocr Relat Cancer. 2004;11:603-22.
78. Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol. 2003;23:6159-73.
79. Das UN. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins Leukot Essent Fatty Acids. 1991;61:157-63.
80. Ando K, Nagata K, Yoshida R, Kikugawa K, Suzuki M. Effect of n-3 polyunsaturated fatty acid supplementation on lipid peroxidation of rat organs. Lipids. 2000;35:401-7.
81. Arita K, Kobuchi H, Utsumi T, Takehara Y, Akiyama J, Horton AA, Utsumi K. Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids. Biochem Pharmacol. 2001;62:821-8.
82. Igarashi M, Miyazawa T. Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? Biochem Biophys Res Commun. 2000;270:649-56.
83. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene. 2003;22:8983-98.
84. Rose DP, Connolly JM, Rayburn J, Coleman M. Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J Natl Cancer Inst. 1995;87:587-92.
85. Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev. 2004;62:333-9.
86. Bernard-Gallon DJ, Vissac-Sabatier C, Antoine-Vincent D, Rio PG, Maurizis JC, Fustier P, Bignon YJ. Differential effects of n-3 and n-6 polyunsaturated fatty acids on BRCA1 and BRCA2 gene expression in breast cell lines. Br J Nutr. 2002;87:281-9.
87. Farmer SR. Regulation of PPARgamma activity during adipogenesis. Int J Obes Relat Metab Disord. 2005;29(Suppl 1):S13-6.
88. Yoshizumi T, Ohta T, Ninomiya I, Terada I, Fushida S, Fujimura T, Nishimura G, Shimizu K, Yi S, Miwa K. Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects. Int J Oncol. 2004;25:631-9.
89. Chen Y, Lee WH, Chew HK. Emerging roles of BRCA1 in transcriptional regulation and DNA repair. J Cell Physiol. 1999;181:385-92.
90. Monteiro AN. Participation of BRCA1 in the DNA repair response.via transcription. Cancer Biol Ther. 2002;1:187-8.
91. Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005;102:9176-81.
92. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA, King MC. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci U S A. 2002;99:7560-5.
93. Burgermeister E, Tencer L, Liscovitch M. Peroxisome proliferator- activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. Oncogene. 2003;22:3888-900.
94. Bousserouel S, Raymondjean M, Brouillet A, Bereziat G, Andreani M. Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1beta-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids. Eur J Biochem. 2004;271:4462-73.
95. Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I. A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95. Biochem J. 2004;378:673-9.
96. Huang JW, Chen CL, Chuang NN. P120-GAP associated with syndecan-2 to function as an active switch signal for Src upon transformation with oncogenic ras. Biochem Biophys Res Commun. 2005;329:855-62.
97. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S. Correlation of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leuk Res. 2000;24:461-8.
98. Wu LL, Chiou CC, Chang PY, Wu JT. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta. 2004;339:1-9.
99. Harris RE, Alshafie GA, bou-Issa H, Seibert K. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 2000;60:2101-3.
100. Liu CH, Chang SH, Narko K, Trifan OC, Wu M-T, Smith E, Haudenschild C, Lane TF, Hla T. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. 2001;276:18563-9.
101. Singh J, Hamid R, Reddy BS. Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. Cancer Res. 1997;57:3465-70.
102. Badawi AF, El-Sohemy A, Stephen LL, Ghoshal AK, Archer MC. The effect of dietary n-3 and n-6 polyunsaturated fatty acids on the expression of cyclooxygenase 1 and 2 and levels of p21 in rat mammary glands. Carcinogenesis. 1998;19:903-10.