Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis

Carcinogenesis

Volumn 25, Issue 5, 2004, Pages 741-748

  Cabanes, Anna ^b   Wang, Mingyue ^b   Olivo, Susan ^b   DeAssis, Sonia ^b   Gustafsson, Jan Åke ^a   Khan, Galam ^b   Hilakivi Clarke, Leena ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BRCA1 PROTEIN; DRUG VEHICLE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENISTEIN; MESSENGER RNA;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; BREAST TUMOR; CANCER RISK; CELL DIFFERENTIATION; CONTROLLED STUDY; DENSITY; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EXPOSURE; DRUG MECHANISM; ESTROGEN ACTIVITY; FEMALE; GENE EXPRESSION; MALIGNANT TRANSFORMATION; MAMMARY GLAND; MORPHOLOGY; NONHUMAN; PERINATAL PERIOD; PREPUBERTY; PRIORITY JOURNAL; RAT; RISK REDUCTION; TISSUE DIFFERENTIATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; BRCA1 PROTEIN; CELL DIVISION; ESTRADIOL; FEMALE; GENISTEIN; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; SEXUAL MATURATION; UP-REGULATION;

EID: 2442535038     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh065     Document Type: Article

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