Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids

Biochemical Pharmacology

Volumn 62, Issue 7, 2001, Pages 821-828

  Arita, Kayo ^a,b   Kobuchi, Hirotsugu ^c   Utsumi, Toshihiko ^a   Takehara, Yoshiki ^b   Akiyama, Jitsuo ^d   Horton, Alan A ^e   Utsumi, Kozo ^b  

^a YAMAGUCHI UNIVERSITY   (Japan)

^b University of Tokyo   (Japan)

^c OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d University of Tokyo   (Japan)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Apoptosis; Bid; Caspase; HL 60 cells; Membrane permeability transition; Polyunsaturated fatty acid

Indexed keywords

ARACHIDONIC ACID; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYCLOSPORIN A; CYTOCHROME C; DIMETHYL SULFOXIDE; DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HL 60; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN FAMILY;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CASPASES; CELL DIFFERENTIATION; CELL DIVISION; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; DNA; DNA FRAGMENTATION; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; HL-60 CELLS; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; TRIGLYCERIDES;

EID: 0035479963     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00723-7     Document Type: Article

References (42)

1. n-3 polyunsaturated fatty acids, and immune function
2. 2+ activation of PDH
3. Neonatal polyunsaturated fatty acid metabolism
4. Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids
5. Polyunsaturated fatty acid regulation of gene expression
6. 2 in myocardium
7. Dietary polyunsaturated fatty acid regulation of gene transcription
8. Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells
9. Effect of l-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients
10. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
11. l-Carnitine, and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation
12. Multiplication and death-type of leukemia cell lines exposed to very long-chain polyunsaturated fatty acids
13. Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells
14. The effects of dietary n-3 polyunsaturated fatty acids on neutrophils
15. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa
16. Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: Role of cyclooxygenase products and endothelium-derived relaxing factor
17. Long-term supplementation with n-3 fatty acids, II: Effect on neutrophil and monocyte chemotaxis
18. Modulation of antioxidant enzymes and apoptosis in mice by dietary lipids and treadmill exercise
19. Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis
20. Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor
21. Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60)
22. 6(3) or rhodamine 123, is a reliable fluorescent probe to assess Δψ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
23. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
24. Fractionation of cell components of animal tissues
25. Damped oscillatory control of mitochondrial respiration and volume
26. The mitochondrial permeability transition
27. Effect of the antiretroviral agent hypericin on rat liver mitochondria
28. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
29. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
30. Cytochrome c: Can't live with it - Can't live without it
31. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
32. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
33. The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
34. Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier
35. The role of long-chain acyl-CoA in the damage of oxidative phosphorylation in heart mitochondria
36. Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria
37. The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane
38. Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A
39. Induction of apoptosis by arachidonic acid in human retinoblastoma Y79 cells: Involvement of oxidative stress
40. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis
41. Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFκB
42. Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells?