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Volumn 69, Issue 2, 2006, Pages 509-519

Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs

Author keywords

[No Author keywords available]

Indexed keywords

CLOFILIUM; DOFETILIDE; IBUTILIDE; NITROGEN; PHENYLALANINE; PNU 0068611A; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; SERINE; THREONINE; TYROSINE; UK 062711 13; UK 064962 01; UK 064963 01; UK 068097; UK 068522; UK 068523; UK 068526 01; UNCLASSIFIED DRUG; VALINE;

EID: 31044447745     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.016741     Document Type: Article
Times cited : (81)

References (38)
  • 2
    • 0026007021 scopus 로고
    • Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog
    • Castle NA (1991) Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog. J Pharmacol Exp Ther 257:342-350.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 342-350
    • Castle, N.A.1
  • 3
    • 0037194634 scopus 로고    scopus 로고
    • Toward a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of HERG K+ channel blockers
    • Cavalli A, Poluzzi E, De Ponti F, and Recanatini M (2002) Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers. J Med Chem 45:3844-3853.
    • (2002) J Med Chem , vol.45 , pp. 3844-3853
    • Cavalli, A.1    Poluzzi, E.2    De Ponti, F.3    Recanatini, M.4
  • 4
    • 0037126062 scopus 로고    scopus 로고
    • Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels
    • Chen J, Seebohm G, and Sanguinetti MC (2002) Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci USA 99:12461-12466.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12461-12466
    • Chen, J.1    Seebohm, G.2    Sanguinetti, M.C.3
  • 6
    • 0036229805 scopus 로고    scopus 로고
    • Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel
    • Ekins S, Crumb WJ, Sarazan RD, Wikel JH, and Wrighton SA (2002) Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel. J Pharmacol Exp Ther 301:427-434.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 427-434
    • Ekins, S.1    Crumb, W.J.2    Sarazan, R.D.3    Wikel, J.H.4    Wrighton, S.A.5
  • 7
    • 0038471102 scopus 로고    scopus 로고
    • The impact of drug-induced QT interval prolongation on drug discovery and development
    • Fermini B and Fossa AA (2003) The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Disc 2:439-447.
    • (2003) Nat Rev Drug Disc , vol.2 , pp. 439-447
    • Fermini, B.1    Fossa, A.A.2
  • 8
    • 1642370447 scopus 로고    scopus 로고
    • Physicochemical features of the HERG channel drug binding site
    • Fernandez D, A Ghanta, GW Kauffman, and MC Sanguinetti (2004) Physicochemical features of the HERG channel drug binding site. J Biol Chem 279:10120-10127.
    • (2004) J Biol Chem , vol.279 , pp. 10120-10127
    • Fernandez, D.1    Ghanta, A.2    Kauffman, G.W.3    Sanguinetti, M.C.4
  • 10
    • 0037276534 scopus 로고    scopus 로고
    • Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241
    • Gessner G and Heinemann SH (2003) Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol 138:161-171.
    • (2003) Br J Pharmacol , vol.138 , pp. 161-171
    • Gessner, G.1    Heinemann, S.H.2
  • 11
    • 2142808323 scopus 로고    scopus 로고
    • Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents
    • Gessner G, Zacharias M, Bechstedt S, Schonherr R, and Heinemann SH (2004) Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Mol Pharmacol 65:1120-1129.
    • (2004) Mol Pharmacol , vol.65 , pp. 1120-1129
    • Gessner, G.1    Zacharias, M.2    Bechstedt, S.3    Schonherr, R.4    Heinemann, S.H.5
  • 12
    • 0032529096 scopus 로고    scopus 로고
    • Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels
    • Herzberg IM, Trudeau MC, and Robertson GA (1998). Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J Physiol 511:3-14.
    • (1998) J Physiol , vol.511 , pp. 3-14
    • Herzberg, I.M.1    Trudeau, M.C.2    Robertson, G.A.3
  • 13
    • 0017332486 scopus 로고
    • Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
    • Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515.
    • (1977) J Gen Physiol , vol.69 , pp. 497-515
    • Hille, B.1
  • 14
    • 0017726385 scopus 로고
    • Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
    • Hondeghem LM and Katzung BG (1977). Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472:373-398.
    • (1977) Biochim Biophys Acta , vol.472 , pp. 373-398
    • Hondeghem, L.M.1    Katzung, B.G.2
  • 15
    • 0031552362 scopus 로고    scopus 로고
    • Development and validation of a genetic algorithm for flexible docking
    • Jones G, Willett P, Glen RC, Leach AR, and Taylor R (1997) Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267:727-748.
    • (1997) J Mol Biol , vol.267 , pp. 727-748
    • Jones, G.1    Willett, P.2    Glen, R.C.3    Leach, A.R.4    Taylor, R.5
  • 17
    • 0035936798 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of cardiac arrhythmias
    • Keating MT and Sanguinetti MC (2001) Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104:569-580.
    • (2001) Cell , vol.104 , pp. 569-580
    • Keating, M.T.1    Sanguinetti, M.C.2
  • 18
    • 0033952902 scopus 로고    scopus 로고
    • Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
    • Lees-Miller JP, Duan Y, Teng GQ, and Duff HJ (2000) Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites. Mol Pharmacol 57:367-374.
    • (2000) Mol Pharmacol , vol.57 , pp. 367-374
    • Lees-Miller, J.P.1    Duan, Y.2    Teng, G.Q.3    Duff, H.J.4
  • 19
    • 0038497465 scopus 로고    scopus 로고
    • Blockade of HERG potassium currents by fluvoxamine: Incomplete attenuation by S6 mutations at F656 or Y652
    • Milnes JT, Crociani O, Arcangeli A, Hancox JC, and Witchel HJ (2003) Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Br J Pharmacol 139:887-898.
    • (2003) Br J Pharmacol , vol.139 , pp. 887-898
    • Milnes, J.T.1    Crociani, O.2    Arcangeli, A.3    Hancox, J.C.4    Witchel, H.J.5
  • 21
    • 0033818157 scopus 로고    scopus 로고
    • Trapping of a methanesulfonanilide by closure of the hERG potassium channel activation gate
    • Mitcheson JS, Chen J, and Sanguinetti MC (2000b) Trapping of a methanesulfonanilide by closure of the hERG potassium channel activation gate. J Gen Physiol 115:229-240.
    • (2000) J Gen Physiol , vol.115 , pp. 229-240
    • Mitcheson, J.S.1    Chen, J.2    Sanguinetti, M.C.3
  • 22
    • 0142091429 scopus 로고    scopus 로고
    • Molecular determinants of high-affinity drug binding to HERG channels
    • Mitcheson JS and Perry MD (2003) Molecular determinants of high-affinity drug binding to HERG channels. Curr Opin Drug Disc Dev 6:667-674.
    • (2003) Curr Opin Drug Disc Dev , vol.6 , pp. 667-674
    • Mitcheson, J.S.1    Perry, M.D.2
  • 26
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A and Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 27
    • 8444244427 scopus 로고    scopus 로고
    • High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: Resistance to mutations of the S6 residues Y652 and F656
    • Ridley JM, Milnes JT, Witchel HJ, and Hancox JC (2004) High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656. Biochem Biophys Res Commun 325:883-891.
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 883-891
    • Ridley, J.M.1    Milnes, J.T.2    Witchel, H.J.3    Hancox, J.C.4
  • 29
    • 0038407463 scopus 로고    scopus 로고
    • Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain
    • Sanchez-Chapula JA, Ferrer T, Navarro-Polanco RA, and Sanguinetti MC (2003) Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Mol Pharmacol 63:1051-1058.
    • (2003) Mol Pharmacol , vol.63 , pp. 1051-1058
    • Sanchez-Chapula, J.A.1    Ferrer, T.2    Navarro-Polanco, R.A.3    Sanguinetti, M.C.4
  • 30
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • Sanguinetti MC, Jiang C, Curran ME, and Keating MT (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81:299-307.
    • (1995) Cell , vol.81 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 31
    • 14644412444 scopus 로고    scopus 로고
    • Predicting drug-hERG channel interactions that cause acquired long QT syndrome
    • Sanguinetti MC and Mitcheson JS (2005) Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends Pharmacol Sci 26:119-124.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 119-124
    • Sanguinetti, M.C.1    Mitcheson, J.S.2
  • 32
    • 0033082093 scopus 로고    scopus 로고
    • Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
    • Sanguinetti MC and Xu QP (1999). Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol 514 (Pt 3): 667-75.
    • (1999) J Physiol , vol.514 , Issue.3 PART , pp. 667-675
    • Sanguinetti, M.C.1    Xu, Q.P.2
  • 35
    • 0034763326 scopus 로고    scopus 로고
    • Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds
    • Steidl JV and Yool AJ (2001) Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophys J 81:2606-2613.
    • (2001) Biophys J , vol.81 , pp. 2606-2613
    • Steidl, J.V.1    Yool, A.J.2
  • 36
    • 0031559897 scopus 로고    scopus 로고
    • Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241
    • Suessbrich H, Schonherr R, Heinemann SH, Lang F, and Busch AE (1997) Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241. FEBS Lett 414:435-438.
    • (1997) FEBS Lett , vol.414 , pp. 435-438
    • Suessbrich, H.1    Schonherr, R.2    Heinemann, S.H.3    Lang, F.4    Busch, A.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.