-
1
-
-
0033954256
-
The Protein Data Bank
-
Berman HM, Westbrook J, Feng Z, Gilliland Feng, Bhat TN, Weissig H, Shindyalov IN, and Bourne PE (2000) The Protein Data Bank. Nucleic Acids Res 28:235-242.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Feng, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
2
-
-
0026007021
-
Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog
-
Castle NA (1991) Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog. J Pharmacol Exp Ther 257:342-350.
-
(1991)
J Pharmacol Exp Ther
, vol.257
, pp. 342-350
-
-
Castle, N.A.1
-
3
-
-
0037194634
-
Toward a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of HERG K+ channel blockers
-
Cavalli A, Poluzzi E, De Ponti F, and Recanatini M (2002) Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers. J Med Chem 45:3844-3853.
-
(2002)
J Med Chem
, vol.45
, pp. 3844-3853
-
-
Cavalli, A.1
Poluzzi, E.2
De Ponti, F.3
Recanatini, M.4
-
4
-
-
0037126062
-
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels
-
Chen J, Seebohm G, and Sanguinetti MC (2002) Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci USA 99:12461-12466.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12461-12466
-
-
Chen, J.1
Seebohm, G.2
Sanguinetti, M.C.3
-
5
-
-
0032478818
-
+ conduction and selectivity
-
+ conduction and selectivity. Science (Wash DC) 280:69-77.
-
(1998)
Science (Wash DC)
, vol.280
, pp. 69-77
-
-
Doyle, D.A.1
Morais Cabral, J.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
Cohen, S.L.6
Chait, B.T.7
MacKinnon, R.8
-
6
-
-
0036229805
-
Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel
-
Ekins S, Crumb WJ, Sarazan RD, Wikel JH, and Wrighton SA (2002) Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel. J Pharmacol Exp Ther 301:427-434.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 427-434
-
-
Ekins, S.1
Crumb, W.J.2
Sarazan, R.D.3
Wikel, J.H.4
Wrighton, S.A.5
-
7
-
-
0038471102
-
The impact of drug-induced QT interval prolongation on drug discovery and development
-
Fermini B and Fossa AA (2003) The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Disc 2:439-447.
-
(2003)
Nat Rev Drug Disc
, vol.2
, pp. 439-447
-
-
Fermini, B.1
Fossa, A.A.2
-
10
-
-
0037276534
-
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241
-
Gessner G and Heinemann SH (2003) Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol 138:161-171.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 161-171
-
-
Gessner, G.1
Heinemann, S.H.2
-
11
-
-
2142808323
-
Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents
-
Gessner G, Zacharias M, Bechstedt S, Schonherr R, and Heinemann SH (2004) Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Mol Pharmacol 65:1120-1129.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1120-1129
-
-
Gessner, G.1
Zacharias, M.2
Bechstedt, S.3
Schonherr, R.4
Heinemann, S.H.5
-
12
-
-
0032529096
-
Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels
-
Herzberg IM, Trudeau MC, and Robertson GA (1998). Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J Physiol 511:3-14.
-
(1998)
J Physiol
, vol.511
, pp. 3-14
-
-
Herzberg, I.M.1
Trudeau, M.C.2
Robertson, G.A.3
-
13
-
-
0017332486
-
Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
-
Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515.
-
(1977)
J Gen Physiol
, vol.69
, pp. 497-515
-
-
Hille, B.1
-
14
-
-
0017726385
-
Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
-
Hondeghem LM and Katzung BG (1977). Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472:373-398.
-
(1977)
Biochim Biophys Acta
, vol.472
, pp. 373-398
-
-
Hondeghem, L.M.1
Katzung, B.G.2
-
15
-
-
0031552362
-
Development and validation of a genetic algorithm for flexible docking
-
Jones G, Willett P, Glen RC, Leach AR, and Taylor R (1997) Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267:727-748.
-
(1997)
J Mol Biol
, vol.267
, pp. 727-748
-
-
Jones, G.1
Willett, P.2
Glen, R.C.3
Leach, A.R.4
Taylor, R.5
-
17
-
-
0035936798
-
Molecular and cellular mechanisms of cardiac arrhythmias
-
Keating MT and Sanguinetti MC (2001) Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104:569-580.
-
(2001)
Cell
, vol.104
, pp. 569-580
-
-
Keating, M.T.1
Sanguinetti, M.C.2
-
18
-
-
0033952902
-
Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
-
Lees-Miller JP, Duan Y, Teng GQ, and Duff HJ (2000) Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites. Mol Pharmacol 57:367-374.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 367-374
-
-
Lees-Miller, J.P.1
Duan, Y.2
Teng, G.Q.3
Duff, H.J.4
-
19
-
-
0038497465
-
Blockade of HERG potassium currents by fluvoxamine: Incomplete attenuation by S6 mutations at F656 or Y652
-
Milnes JT, Crociani O, Arcangeli A, Hancox JC, and Witchel HJ (2003) Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Br J Pharmacol 139:887-898.
-
(2003)
Br J Pharmacol
, vol.139
, pp. 887-898
-
-
Milnes, J.T.1
Crociani, O.2
Arcangeli, A.3
Hancox, J.C.4
Witchel, H.J.5
-
20
-
-
0034710933
-
A structural basis for drug-induced long QT syndrome
-
Mitcheson JS, Chen J, Lin M, Culberson C, and Sanguinetti MC (2000a) A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 97:12329-12333.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12329-12333
-
-
Mitcheson, J.S.1
Chen, J.2
Lin, M.3
Culberson, C.4
Sanguinetti, M.C.5
-
21
-
-
0033818157
-
Trapping of a methanesulfonanilide by closure of the hERG potassium channel activation gate
-
Mitcheson JS, Chen J, and Sanguinetti MC (2000b) Trapping of a methanesulfonanilide by closure of the hERG potassium channel activation gate. J Gen Physiol 115:229-240.
-
(2000)
J Gen Physiol
, vol.115
, pp. 229-240
-
-
Mitcheson, J.S.1
Chen, J.2
Sanguinetti, M.C.3
-
22
-
-
0142091429
-
Molecular determinants of high-affinity drug binding to HERG channels
-
Mitcheson JS and Perry MD (2003) Molecular determinants of high-affinity drug binding to HERG channels. Curr Opin Drug Disc Dev 6:667-674.
-
(2003)
Curr Opin Drug Disc Dev
, vol.6
, pp. 667-674
-
-
Mitcheson, J.S.1
Perry, M.D.2
-
23
-
-
0038743107
-
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches
-
Pearlstein RA, Vaz RJ, Kang J, Chen XL, Preobrazhenskaya M, Shchekotikhin AE, Korolev AM, Lysenkova LN, Miroshnikova OV, Hendrix J, et al. (2003) Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorg Med Chem Lett 13:1829-1835.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 1829-1835
-
-
Pearlstein, R.A.1
Vaz, R.J.2
Kang, J.3
Chen, X.L.4
Preobrazhenskaya, M.5
Shchekotikhin, A.E.6
Korolev, A.M.7
Lysenkova, L.N.8
Miroshnikova, O.V.9
Hendrix, J.10
-
24
-
-
3342988006
-
Structural determinants of HERG channel block by clofilium and ibutilide
-
Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC, and Mitcheson J (2004) Structural determinants of HERG channel block by clofilium and ibutilide. Mol Pharmacol 66:240-249.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 240-249
-
-
Perry, M.1
De Groot, M.J.2
Helliwell, R.3
Leishman, D.4
Tristani-Firouzi, M.5
Sanguinetti, M.C.6
Mitcheson, J.7
-
26
-
-
0027136282
-
Comparative protein modelling by satisfaction of spatial restraints
-
Sali A and Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
-
(1993)
J Mol Biol
, vol.234
, pp. 779-815
-
-
Sali, A.1
Blundell, T.L.2
-
27
-
-
8444244427
-
High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: Resistance to mutations of the S6 residues Y652 and F656
-
Ridley JM, Milnes JT, Witchel HJ, and Hancox JC (2004) High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656. Biochem Biophys Res Commun 325:883-891.
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 883-891
-
-
Ridley, J.M.1
Milnes, J.T.2
Witchel, H.J.3
Hancox, J.C.4
-
29
-
-
0038407463
-
Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain
-
Sanchez-Chapula JA, Ferrer T, Navarro-Polanco RA, and Sanguinetti MC (2003) Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Mol Pharmacol 63:1051-1058.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 1051-1058
-
-
Sanchez-Chapula, J.A.1
Ferrer, T.2
Navarro-Polanco, R.A.3
Sanguinetti, M.C.4
-
30
-
-
0029002969
-
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
-
Sanguinetti MC, Jiang C, Curran ME, and Keating MT (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81:299-307.
-
(1995)
Cell
, vol.81
, pp. 299-307
-
-
Sanguinetti, M.C.1
Jiang, C.2
Curran, M.E.3
Keating, M.T.4
-
31
-
-
14644412444
-
Predicting drug-hERG channel interactions that cause acquired long QT syndrome
-
Sanguinetti MC and Mitcheson JS (2005) Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends Pharmacol Sci 26:119-124.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 119-124
-
-
Sanguinetti, M.C.1
Mitcheson, J.S.2
-
32
-
-
0033082093
-
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
-
Sanguinetti MC and Xu QP (1999). Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol 514 (Pt 3): 667-75.
-
(1999)
J Physiol
, vol.514
, Issue.3 PART
, pp. 667-675
-
-
Sanguinetti, M.C.1
Xu, Q.P.2
-
35
-
-
0034763326
-
Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds
-
Steidl JV and Yool AJ (2001) Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophys J 81:2606-2613.
-
(2001)
Biophys J
, vol.81
, pp. 2606-2613
-
-
Steidl, J.V.1
Yool, A.J.2
-
36
-
-
0031559897
-
Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241
-
Suessbrich H, Schonherr R, Heinemann SH, Lang F, and Busch AE (1997) Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241. FEBS Lett 414:435-438.
-
(1997)
FEBS Lett
, vol.414
, pp. 435-438
-
-
Suessbrich, H.1
Schonherr, R.2
Heinemann, S.H.3
Lang, F.4
Busch, A.E.5
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