Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 10, 2003, Pages 1829-1835

  Pearlstein, Robert A ^a   Vaz, Roy J ^a   Kang, Jiesheng ^a   Chen, Xiao Liang ^a   Preobrazhenskaya, Maria ^b   Shchekotikhin, Andrey E ^b   Korolev, Alexander M ^b   Lysenkova, Ludmila N ^b   Miroshnikova, Olga V ^b   Hendrix, James ^a   Rampe, David ^a  

^a SANOFI   (France)

^b GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; AROMATIC COMPOUND; CATION; CISAPRIDE; DOFETILIDE; FEXOFENADINE; HALOPERIDOL; META TYROSINE; NITROGEN; PEPTIDE; PHENYLALANINE; PIMOZIDE; POTASSIUM CHANNEL; SERTINDOLE; TERFENADINE; VERAPAMIL;

ARTICLE; CHEMICAL MODEL; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; HYDROPHOBICITY; IC 50; INHIBITION KINETICS; MOLECULAR MODEL; MOLECULAR PROBE; PATCH CLAMP; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURAL HOMOLOGY;

EID: 0038743107     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00196-3     Document Type: Article

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