Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241

FEBS Letters

Volumn 414, Issue 2, 1997, Pages 435-438

  Suessbrich, Hartmut ^a   Schönherr, Roland ^b   Heinemann, Stefan H ^b   Lang, Florian ^a   Busch, Andreas E ^a,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Arrhythmia; Clofilium; HERG; K+ channel; Torsades de pointes

Indexed keywords

ANTIARRHYTHMIC AGENT; CLOFILIUM; LY 97421; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; DOSE RESPONSE; FROG; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CATION TRANSPORT PROTEINS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HUMANS; KINETICS; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POINT MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; QUATERNARY AMMONIUM COMPOUNDS; RECOMBINANT PROTEINS; SHAL POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; XENOPUS LAEVIS;

ANURA;

EID: 0031559897     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01030-2     Document Type: Article

References (22)

1. [1] Kopia, G.A., Eller, B.T., Patterson, E., Shea, M.J. and Lucchesi, B.R. (1985) Eur. J. Pharm. 116, 49-61.
2. [2] Arena, J.P. and Kass, R.S. (1988) Mol. Pharmacol. 34, 60-66.
3. [3] Honore, E., Attali, B., Romey, C., Heurteaux, C., Ricard, P., Lesage, F., Lazdunski, M. and Barhanin, J. (1992) EMBO J. 10, 2805-2811.
4. [4] Yamagishi, T., Ishii, K. and Taira, N. (1995) Eur. J. Pharmacol. 281, 151-159.
5. [5] Snyders, D.J. and Yeola, S.W. (1995) Circ. Res. 77, 575-583.
6. [6] Folander, K., Smith, J.F., Antanavage, J., Bennett, C., Stein, R.B. and Swanson, R. (1990) Proc. Natl. Acad. Sci. USA 87, 2975-2979.
7. [7] Busch, A.E., Kopp, H.-G., Waldegger, S., Samarzija, I., Suessbrich, H., Raber, G., Kunzelmann, K., Ruppersberg, J.P. and Lang, F. (1995) J. Physiol. 491, 735-741.
8. [8] Warmke, J.E. and Ganetzky, B. (1994) Proc. Natl. Acad. Sci. USA 91, 3438-3442.
9. [9] Schönherr, R. and Heinemann, S.H. (1996) J. Physiol. 493, 635-642.
10. [10] Murai, T., Kakizuka, A., Takumi, T., Ohkubo, H. and Nakanishi, S. (1989) Biochem. Biophys. Res. Comm. 161, 176-181.
11. [11] Stühmer, W., Stocker, M., Sakmann, B., Seeburg, P., Baumann, A., Grupe, A. and Pongs, O. (1988) FEBS Lett. 242, (1) 199-206.
12. [12] McKinnon, D. (1989) J. Biol. Chem. 264, (14) 8230-8236.
13. [13] Stühmer, W., Ruppersberg, J.P., Schröter, K.H., Sakmann, B., Stocker, M., Giese, K.P., Perschke, A., Baumann, A. and Pongs, O. (1989) EMBO J. 8, (11) 3235-3244.
14. [14] Kamb, A., Weir, M., Rudy, B., Varmus, H. and Kenyon, C. (1989) Proc. Natl. Acad. Sci. USA 86, (12) 4372-4376.
15. [15] Roberds, S.L., Knoth, K.M., Po, S., Blair, T.A., Bennett, P.B., Hartshorne, R.P., Snyders, D.J. and Tamkun, M.M. (1993) J. Cardiovasc. Electrophysiol. 4, 68-80.
16. [16] Fakler, B., Brändle, U., Glowatzki, E., Zenner, H.P. and Ruppersberg, J.P. (1994) Neuron 13, 1413-1420.
17. [17] Liman, E.R., Tytgat, J. and Hess, P. (1992) Neuron 9, 861-871.
18. [18] Sanguinetti, M.C., Jiang, C., Curran, M.E. and Keating, M.T. (1995) Cell 81, 299-307.
19. [19] Malayev, A.A., Nelson, D.J. and Philipson, L.H. (1995) Mol. Pharmacol. 47, (1) 198-205.
20. [20] Suessbrich, H., Schönherr, R., Heinemann, S.H., Attali, B., Lang, F. and Busch, A.E. (1997) Br. J. Pharmacol. 120, 968-974.
21. [21] Suessbrich, H., Waldegger, S., Lang, F. and Busch, A.E. (1996) FEBS Lett. 385, 77-80.
22. [22] Ficker, E., Jarolimek, W., Kiehn, J., Baumann, A. and Brown, A.M. (1997) Biophys. J. 72, A140.