Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels

Journal of Physiology

Volumn 511, Issue 1, 1998, Pages 3-14

  Herzberg, Ian M ^a,b   Trudeau, Matthew C ^a   Robertson, Gail A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV2.1; POTASSIUM CHANNEL M EAG; SHAKER POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; FEMALE; NONHUMAN; ONCOGENE; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; XENOPUS; AMINO ACID SEQUENCE; CONTROLLED STUDY; DRUG SENSITIVITY; ESCHERICHIA COLI; GENE; HERG GENE; IN VIVO STUDY; M EAG GENE; PROTEIN DOMAIN; VOLTAGE CLAMP TECHNIQUE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PIPERIDINES; POINT MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; PYRIDINES; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

EID: 0032529096     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.003bi.x     Document Type: Article

References (47)

1. + channels: II. The components of gating currents and a model of channel activation. Biophysical Journal 66, 1011-1021.
2. BUCK, K. J. & AMARA, S. G. (1994). Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proceedings of the National Academy of Sciences of the USA 91, 12584-12588.
3. CHOI, K. L., ALDRICH, R. W. & YELLEN, G. (1991). Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K channels. Proceedings of the National Academy of Sciences of the USA 88, 5092-5095.
4. CURRAN, M. E., SPLAWSKI, I, TIMOTHY, K. W., VINCENT, G. M., GREEN, E. D. & KEATING, M. T. (1995). A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795-803.
5. DE BIASI, M., HARTMANN, H. A., DREWE, J. A., TAGLIALATELA, M., BROWN, A. M. & KIRSCH, G. E. (1993). Inactivation determined by a single site in K pores. Pflügers Archiv 422, 354-363.
6. DURELL, S. R. & GUY, H. R. (1996). Structural model of the outer vestibule and selectivity filter of the Shaker voltage-gated K channel. Neuropharmacology 35, 761-773.
7. HARTMANN, H. A., KIRSCH, G. E., DREWE, J. A., TAGLIALATELA, M., JOHO, R. H. & BROWN, A. M. (1991). Exchange of conduction pathways between two related K channels. Science 251, 942-944.
8. HOSHI, T., ZAGOTTA, W. N. & ALDRICH, R. W. (1991). Two types of inactivation in Shaker K channels: effects of alterations in the carboxy-terminal region. Neuron 7, 547-556.
9. KAVANAUGH, M. P., VARNUM, M. D., OSBOURNE, P. B., CHRISTIE, M. J., BUSCH, A. E., ADELMAN, J. P. & NORTH, R. A. (1991). Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels. Journal of Biological Chemistry 266, 7583-7587.
10. KIEHN, J., LACERDA, A., WIBLE, B. & BROWN, A. (1996). Molecular physiology and pharmacology of HERG: single channel currents and block by dofetilide. Circulation 94, 2572-2579.
11. LEVIN, L. R. & REED, R. R. (1995). Identification of functional domains of adenylyl cyclase using in vivo chimeras. Journal of Biological Chemistry 270, 7573-7579.
12. + channel. Nature 353, 752-756.
13. + channel determined by construction of multimeric cDNAs. Neuron 9, 861-871.
14. LIU, M., CHEN, T.-Y., AHAMED, B., Li, J. & YAU, K.-W. (1994). Calcium-calmodulin modulation of the olfactory cyclic nucleotidegated cation channel. Science 266, 1348-1354.
15. + channel result in corresponding decreases in gating charge. Neuron 8, 531-540.
16. Kr. Circulation Research 81, 870-878.
17. LOPEZ-BARNEO, J., HOSHI, T., HEINEMANN, S. H. & ALDRICH, R. W. (1993). Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors and Channels 1, 61-71.
18. MACKINNON, R., HEGINBOTHAM, L. & ABRAMSON, T. (1990). Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron 5, 767-771.
19. MACKINNON, R. & MILLER, C. (1989). Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science 245, 1382-1385.
20. MACKINNON, R. & YELLEN, G. (1990). Mutations affecting TEA blockade and ion permeation in voltage-activated K channels. Science 250, 376-279.
21. MOLINA, A., CASTELLANO, A. G. & LOPEZ-BARNEO, J. (1997). Pore mutations in Shaker K channels distinguish between the sites of tetraethylammonium and C-type inactivation. Journal of Physiology 499, 361-367.
22. MOORE, K. W. & BLAKELY, R. D. (1994). Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs. Biotechniques 137, 130-135.
23. PAJOR, A., HIRAYAMA, A. & WRIGHT, E. R. (1992). Molecular evidence for two renal Na/glucose cotransporters. Biochimica et Biophysica Ada 1106, 216-220.
24. PAPAZIAN, D. M., SHAO, X. M., SEOH, S.-A., MOCK, A. F., HUANG, Y. & WAINSTOCK, D. H. (1995). Electrostatic interactions of S4 voltage sensor in Shaker K channels. Neuron 14, 1293-1301.
25. PAPAZIAN, D. M., TIMPE, L. C., JAN, Y. N. & JAN, L. Y. (1991). Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349, 305-310.
26. PEROZO, E., SANTACRUZ-TOLOZA, L., STEFANI, E., BEZANILLA, F. & PAPAZIAN, D. M. (1994). S4 mutations alter gating currents of Shaker K channels. Biophysical Journal 66, 345-354.
27. ROBERTSON, G. A., WARMKE, J. W. & GANETZKY, B. (1996). Potassium currents expressed from Drosophila and Mouse eag cDNAs in Xenopusoocytes. Neuropharmacology 35, 841-850.
28. RUDY, L. & IVERSON, L. E. (1992). Ion Channels. Academic Press, New York.
29. Kr potassium channel. Cell 81, 299-307.
30. SANGUINETTI, M. C. & JURKIEWICZ, N. K. (1990). Two components of cardiac delayed rectifier K current. Journal of General Physiology 96, 195-215.
31. SCHLIEF, T, SCHÖNHERR, R. & HEINEMANN, S. H. (1996). Modification of C-type inactivating Shaker potassium channels by chloramine-T. Pflügers Archiv 431, 483-493.
32. SCHÖNHERR, R. & HEINEMANN, S. H. (1996). Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. Journal of Physiology 493, 635-642.
33. SCHOPPA, N. E., McCORMACK, K., TANOUYE, M. A. & SIGWORTH, F. J. (1992). The size of gating charge in wild-type and mutant Shaker potassium channels. Science 255, 1712-1715.
34. SHIBASAKI, T. (1987). Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. Journal of Physiology 387, 227-250.
35. SMITH, P. L., BAUKROWITZ, T. & YELLEN, G. (1996). The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379, 833-836.
36. SPECTOR, P. S., CURRAN, M. E., KEATING, M. T. & SANGUINETTI, M. C. (1996b). Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier channel. Circulation Research 78, 499-503.
37. Kr channel. Journal of General Physiology 107, 611-619.
38. SUESSBRICH, H., SCHÖNHERR, R., HEINEMANN, S. H., ATTALI, B., LANG, F. & BUSCH, A. E. (1997). The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. British Journal of Pharmacology 120, 968-974.
39. TRUDEAU, M. C., WARMKE, J. W., GANETZKY, B. & ROBERTSON, G. (1995). HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269, 92-95.
40. TRUDEAU, M. C., WARMKE, J. W., GANETZKY, B. & ROBERTSON, G. (1996). HERG sequence correction [letter]. Science 272, 1087.
41. WANG, S., LIU, S., MORALES, M. J., STRAUSS, H. C. & RASMUSSON, R. L. (1997). A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. Journal of Physiology 502, 45-60.
42. WANG, S., MORALES, M. J., LIU, S., STRAUSS, H. C. & RASMUSSON, R. L. (1996). Time, voltage and ionic concentration dependence of rectification of H-ERG expressed in Xenopus oocytes. FEBS Letters 389, 167-173.
43. WARMKE, J., DRYSDALE, R. & GANETZKY, B. (1991). A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 252, 1560-1562.
44. WARMKE, J. W. & GANETZKY, B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proceedings of the National Academy of Sciences of the USA 91, 3438-3442.
45. YELLEN, G., JURMAN, M. E., ABRAMSON, T. & MACKINNON, R. (1991). Mutations affecting internal TEA blockade identify the probable pore-forming region of a K channel. Science 251, 939-942.
46. ZAGOTTA, W. N., HOSHI, T., DITTMAN, J. & ALDRICH, R. W. (1994). Shaker potassium channel gating II: Transitions in the activation pathway. Journal of General Physiology 103, 279-319.
47. ZHOU, Z., GONG, Q., YE, B., FAN, Z., MAKIELSKI, J. C., ROBERTSON, G. A. & JANUARY, C. T. (1998). Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophysical Journal 74, 230-241.