메뉴 건너뛰기




Volumn 2, Issue 2, 2005, Pages 215-230

Synthetic strategies towards O6-substituted guanine derivatives and their application in medicine

Author keywords

AGT inhibitors; Catalysis; O6 substituted guanines; Rearrangement

Indexed keywords


EID: 30444448357     PISSN: 15701794     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570179053545369     Document Type: Review
Times cited : (3)

References (122)
  • 3
    • 0014672640 scopus 로고
    • b) Loveless, A. Nature, 1969, 223, 206.;
    • (1969) Nature , vol.223 , pp. 206
    • Loveless, A.1
  • 48
    • 46249114738 scopus 로고    scopus 로고
    • 18F-alcohol concentration would be extremely substoichiometric.
    • 18F-alcohol concentration would be extremely substoichiometric.
  • 59
    • 46249129230 scopus 로고    scopus 로고
    • Jpn. Kokai Tokkyo Koho JP 05213952 A2 930824 Heisei; Chem. Abstr, 1994, 120, 8412
    • Sato; Jpn. Kokai Tokkyo Koho JP 05213952 A2 930824 Heisei; Chem. Abstr., 1994, 120, 8412.
    • Sato1
  • 60
    • 46249103040 scopus 로고
    • Eur. Pat. Appl. EP 543095 A2 930526;, 180812
    • Igi, T. Hayashi; Eur. Pat. Appl. EP 543095 A2 930526; Chem. Abstr., 1993, 119, 180812.
    • (1993) Chem. Abstr , vol.119
    • Igi, T.H.1
  • 61
    • 46249111986 scopus 로고
    • PCT Int. Appl. WO 92113859 A1 920820;, 233720
    • Hanson, C. PCT Int. Appl. WO 92113859 A1 920820; Chem. Abstr., 1992, 117, 233720.
    • (1992) Chem. Abstr , vol.117
    • Hanson, C.1
  • 62
    • 46249110843 scopus 로고
    • Int. Appl. WO 9315075 A1 930805;, 30779
    • Killen, R. J. PCP Int. Appl. WO 9315075 A1 930805; Chem. Abstr., 1994, 120, 30779.
    • (1994) Chem. Abstr , vol.120
    • Killen, R.J.P.1
  • 64
    • 46249133824 scopus 로고    scopus 로고
    • Unpublished results from our laboratory show that reaction times of more than 2 h lead to a total mono deacetylation in 9-position of the 2-amino-purine (guanine).
    • Unpublished results from our laboratory show that reaction times of more than 2 h lead to a total mono deacetylation in 9-position of the 2-amino-purine (guanine).
  • 67
    • 46249106902 scopus 로고    scopus 로고
    • The authors stated that crystallization of the product set in when the solution was evaporated. To our experience it is essential to evaporate at room temperature because higher temperatures using a vacuum evaporator lead to unwanted side reactions and reduced the yield significantly. In the worst case, no crystallization was observed
    • The authors stated that crystallization of the product set in when the solution was evaporated. To our experience it is essential to evaporate at room temperature because higher temperatures using a vacuum evaporator lead to unwanted side reactions and reduced the yield significantly. In the worst case, no crystallization was observed.
  • 68
    • 46249124105 scopus 로고    scopus 로고
    • Simon, A. B.; Brit. Pat. 767216, 1957; Chem. Abst. 1957, 51, 14796d.
    • Simon, A. B.; Brit. Pat. 767216, 1957; Chem. Abst. 1957, 51, 14796d.
  • 69
    • 46249109639 scopus 로고
    • US 2815346, 6417b
    • Burroughs Wellcome & Co. US 2815346, 1955; Chem. Abst. 1958, 52, 6417b.
    • (1955) Chem. Abst , vol.52
  • 70
    • 46249113609 scopus 로고    scopus 로고
    • These unpublished results were obtained in our laboratory. The reaction time of bubbling chlorine through the solution should not exceed 10 h. It is essential to reduce the of the reaction mixture at room temperature (25°C) by half. Then precipitation of 3 set in.
    • These unpublished results were obtained in our laboratory. The reaction time of bubbling chlorine through the solution should not exceed 10 h. It is essential to reduce the volume of the reaction mixture at room temperature (25°C) by half. Then precipitation of 3 set in.
  • 77
    • 46249087675 scopus 로고    scopus 로고
    • The authors would like to indicate that the published yield of the trimethyl ammonium salt (4) of 79 % can be enhanced up to 95 % by reducing the final DMSO solution by half before adding diethyl ether.
    • The authors would like to indicate that the published yield of the trimethyl ammonium salt (4) of 79 % can be enhanced up to 95 % by reducing the final DMSO solution by half before adding diethyl ether.
  • 79
    • 46249114193 scopus 로고    scopus 로고
    • 6-ether moiety.
    • 6-ether moiety.
  • 103
    • 84977277519 scopus 로고    scopus 로고
    • Thermal processes: a Fuchs, H.; Gottlieb, M.; Pfleiderer, W. Chem. Ber., 1978, 111, 982.;
    • Thermal processes: a) Fuchs, H.; Gottlieb, M.; Pfleiderer, W. Chem. Ber., 1978, 111, 982.;
  • 106
    • 0014711926 scopus 로고    scopus 로고
    • reduction: a Kempter, F. E.; Rokos, H.; Pfleiderer, W. Chem. Ber., 1970, 103, 885.;
    • reduction: a) Kempter, F. E.; Rokos, H.; Pfleiderer, W. Chem. Ber., 1970, 103, 885.;
  • 109
    • 33947482661 scopus 로고    scopus 로고
    • Mannich base: Taylor, E. C. and Garcia, E. E. J. Am. Chem. Soc.; 1964, 86, 4720.;
    • Mannich base: Taylor, E. C. and Garcia, E. E. J. Am. Chem. Soc.; 1964, 86, 4720.;
  • 110
    • 46249109383 scopus 로고    scopus 로고
    • Vilsmeier-Haak reagents: a Yoneda, F.; Higuchi, M.; Matsumura, T.; Senga, K. Bull. Chem. Soc. Jpn., 1973, 1836.;
    • Vilsmeier-Haak reagents: a) Yoneda, F.; Higuchi, M.; Matsumura, T.; Senga, K. Bull. Chem. Soc. Jpn., 1973, 1836.;
  • 112
    • 0016909005 scopus 로고    scopus 로고
    • 1,1-dimethylhydrazones: Yoneda, F.; Nagamatsu, T. J. Chem. Soc., Perkin Trans. 1, 1976, 35, 1547.
    • 1,1-dimethylhydrazones: Yoneda, F.; Nagamatsu, T. J. Chem. Soc., Perkin Trans. 1, 1976, 35, 1547.
  • 116
    • 46249106376 scopus 로고    scopus 로고
    • The temperature should not exceed 80°C and the benzylacohol must be freshly distilled and oxygen free
    • Optimization of this method was achieved in our laboratory, and the benzylacohol must be freshly distilled and oxygen free
    • Optimization of this method was achieved in our laboratory. The temperature should not exceed 80°C and the benzylacohol must be freshly distilled and oxygen free.
  • 117
    • 46249105345 scopus 로고    scopus 로고
    • These observations were made in our laboratory during optimization of the literature procedure
    • These observations were made in our laboratory during optimization of the literature procedure.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.