Synthesis of radiolabeled O6-benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 45, Issue 14, 2002, Pages 1239-1252

  Zheng, Qi Huang ^a   Liu, Xuan ^a   Fei, Xiangshu ^a   Wang, Ji Quan ^a   Ohannesian, David W ^a   Erickson, Leonard C ^a   Stone, K Lee ^a   Martinez, Tanya D ^a   Miller, Kathy D ^a   Hutchins, Gary D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 amino 6 O 11C (methoxymethyl)benzyloxy 9 benzyl purines; Carbon 11; DNA repair protein; O6 alkylguanine DNA alkyltransferase; Positron emission tomography; Radiolabeled O6 benzylguanine derivatives

Indexed keywords

ALKYLATION; BIOSYNTHESIS; CARBON; PHASE SEPARATION; POSITRON EMISSION TOMOGRAPHY; POSITRONS; PROTEINS; REPAIR; TUMORS;

2-AMINO-6-O-[11C]- [(METHOXYMETHYL)BENZYLOXY]-9-BENZYL PURINE; ALKYLTRANSFERASE; CARBON-11; DNA REPAIR PROTEINS; METHOXYMETHYL; O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; RADIOLABELED O6-BENZYLGUANINE DERIVATIVE; RADIOLABELLING; SYNTHESISED; TUMOR IMAGING AGENTS;

DNA;

2 AMINO 6 CHLOROPURINE; 2 AMINO 6 O [(2' METHOXYMETHYL)BENZYLOXY] 9 BENZYLPURINE; 2 AMINO 6 O [(3' METHOXYMETHYL)BENZYLOXY] 9 BENZYLPURINE; 2 AMINO 6 O [(4' METHOXYMETHYL)BENZYLOXY] 9 BENZYLPURINE; BENZYLGUANINE OXYGEN 6; DNA; GUANINE DERIVATIVE; METHYL GROUP; PROTEIN; PURINE DERIVATIVE; TRACER; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; PURIFICATION; RADIOCHEMISTRY; SOLID PHASE EXTRACTION; SYNTHESIS;

EID: 0036941302     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.636     Document Type: Article

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