Modified guanines representing O6-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: Synthesis, stability, and ab initio studies

Chemical Research in Toxicology

Volumn 15, Issue 3, 2002, Pages 380-387

  Balu, Narayanan ^a   Gamcsik, Michael P ^a   Colvin, Michael E ^b   Colvin, O Michael ^a   Dolan, M Eileen ^c   Ludeman, Susan M ^a  

^a DUKE CANCER INSTITUTE   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACROLEIN; CHLOROACETALDEHYDE; CYCLOPHOSPHAMIDE; DIMETHYL SULFOXIDE; DNA; GUANINE DERIVATIVE; IFOSFAMIDE; O 6 (ETHANALYL)GUANINE; O 6 (N PROPANALYL)GUANINE; OXIME DERIVATIVE; PHOSPHATE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CALCULATION; CHEMICAL REACTION; CYCLIZATION; DECOMPOSITION; ENERGY; HALF LIFE TIME; HYDROLYSIS; LEUKEMIA; MOLECULAR STABILITY; PH; QUANTUM MECHANICS; SYNTHESIS; TEMPERATURE DEPENDENCE;

ACETALDEHYDE; ACROLEIN; ALKYLATION; ANTINEOPLASTIC AGENTS, ALKYLATING; CYCLOPHOSPHAMIDE; DNA DAMAGE; GUANINE; HUMANS; LEUKEMIA;

EID: 0036131028     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0101503     Document Type: Article

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