An approach to the evaluation of the activity of the DNA repair enzyme O6-methylguanine-DNA-methyl-transferase in tumor tissue in vivo: Syntheses of 6-benzyloxy-9-(2-[18F]fluoroethyl)-9H-purin-2-yl-amine and 6-benzyloxy-7-(2-[18F]fluoroethyl)-7H-purin-2-yl-amine

Applied Radiation and Isotopes

Volumn 56, Issue 3, 2002, Pages 511-517

  Schirrmacher, Ralf ^a   Nesseler, Esther ^a   Hamkens, Wilhelm ^a   Eichhorn, Uta ^a   Schreckenberger, Mathias ^a   Kaina, Bernd ^a   Rösch, Frank ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

6 benzyloxy 9H purin 2 ylamine; Alkyltransferase; MGMT

Indexed keywords

ALKYLATION; AMINES; CELLS; ENZYMES; TUMORS;

BIODISTRIBUTION;

DNA;

6 BENZYLOXY 7 (2 FLUOROETHYL) 7H PURIN 2 YL AMINE F18; 6 BENZYLOXY 9 (2 FLUOROETHYL) 9H PURIN 2 YL AMINE F18; ANTINEOPLASTIC AGENT; DNA METHYLTRANSFERASE; TRACER; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; EVALUATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET ORGAN; TUMOR; TUMOR RESISTANCE;

ALKYLATING AGENTS; ANIMALS; DNA REPAIR; DRUG RESISTANCE; ENZYME INHIBITORS; FLUORINE RADIOISOTOPES; HELA CELLS; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PURINES; TISSUE DISTRIBUTION;

EID: 0036152457     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(01)00155-5     Document Type: Article

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