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Volumn 43, Issue 22, 2000, Pages 4071-4083

Resistance-modifying agents. 8. Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-alkenyl-, O6-cycloalkenyl-, and O6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O6-(1-cyclopentenylmethyl) guanine

(12) Griffin, R J a Arris, C E b Bleasdale, C a Boyle, F T c Calvert, A H b Curtin, N J b Dalby, C a Kanugula, S d Lembicz, N K a Newell, D R b Pegg, A E d Golding, B T a

a NEWCASTLE UNIVERSITY (United Kingdom)

b NEWCASTLE UNIVERSITY (United Kingdom)

c ASTRAZENECA (United Kingdom)

d PENN STATE COLLEGE OF MEDICINE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O (1 CYCLOBUTENYLMETHYL)GUANINE; 6 O (1 CYCLOPENTENYLMETHYL)GUANINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE INHIBITOR; 6 O BENZYLGUANINE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORECTAL CARCINOMA; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS, ALKYLATING; CELL EXTRACTS; DACARBAZINE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME INHIBITORS; GUANINE; HUMANS; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034597607 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm000961o Document Type: Article

Times cited : (49)

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