Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus

Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2003, Pages 1531-1537

  Chen, Xinchao ^a   Kern, Earl R ^b   Drach, John C ^c   Gullen, Elizabeth ^d   Cheng, Yung Chi ^d   Zemlicka, Jiri ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 (2 HYDROXY)ETHYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 ALLYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 ALLYLOXY 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 BENZYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 CHLOROPURINE METHYLENECYCLOPROPANE; 2 AMINO 6 CYCLOHEXYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 CYCLOPROPYLMETHOXY 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 CYCLOPROPYLMETHYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 ISOPROPYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 PENTYLOXY 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 PENTYLTHIO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 PROPARGYLAMINO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 PROPOXY 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINO 6 PROPYLTHIO 9 [(2 HYDROXYMETHYL)CYCLOPROPYLIDENEMETHYL]PURINE; 2 AMINOPURINE METHYLENECYCLOPROPANE DERIVATIVE; ACICLOVIR; ALKYL GROUP; ALLYL COMPOUND; AMINE; BENZYL DERIVATIVE; CHLORINE; CYCLOPROPANE DERIVATIVE; HYDROXYL GROUP; METHYL GROUP; NUCLEOSIDE ANALOG; PENTANOL; POTASSIUM CARBONATE; PROPANE; PURINE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIVIRAL ACTIVITY; ARTICLE; CATALYST; CELL ASSAY; CELL PROLIFERATION; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EPSTEIN BARR VIRUS; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL; VIRUS REPLICATION;

AMINOPYRINE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS B VIRUS; HERPESVIRIDAE; HUMANS; MICE; PLAQUE ASSAY; PURINE NUCLEOSIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242500884     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0205245     Document Type: Article

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