Synthesis of labelled [15N3]-6-bromopurine, a useful precursor of 15N-labelled O6-alkylguanines, to be used as internal standards for quantitative GC-MS analyses

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 3, 1998, Pages 243-252

  Lolli, Marco ^a,b   Medana, Claudio ^a,b   Romagnano, Stefano ^a,c   Castoldi, Fabio ^a,d   Pozzoli, Stefane ^a   Vago, Fulvio ^a   Fanelli, Roberte ^a   Airoldi, Luisa ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c Zambon Group SpA   (Italy)

^d Isagro Ricerca Srl   (Italy)

Author keywords

6 bromopurine; Nitrogen 15; O6 alkylguanines

Indexed keywords

ISOTOPES; NITROGEN;

6-BROMOPURINE; 6-THIOGUANINE; CYANOGEN BROMIDE; DIAMINOPYRIMIDINE; ETHYL CYANOACETATE; INTERNAL STANDARDS; N ISOTOPES; NITROGEN-15; O6-ALKYLGUANINE; SYNTHESISED;

MASS SPECTROMETRY;

BROMINATED HYDROCARBON; FORMAMIDE; GUANIDINE; GUANINE DERIVATIVE; NITROGEN 15; PRODRUG; PURINE DERIVATIVE; PYRIMIDINE; TIOGUANINE;

ARTICLE; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; ISOTOPE DILUTION ASSAY; ISOTOPE LABELING; MASS SPECTROMETRY; NITROSATION; POLYMERIZATION; REDUCTION; STANDARD;

EID: 0031934819     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199803)41:3<243::AID-JLCR73>3.0.CO;2-H     Document Type: Article

References (20)

1. Miller E. C. and Miller J. A. - Cancer 47: 1055 (1981)
2. Schut H. A.J. and Shiverick K. T. - FASEB. J. 6: 2942 (1992)
3. McCloskey J. A. and Crain P. F. - Int. J. Mass Spectrom. Ion Process 118/119: 593 (1992)
4. Stillwell W. G., Xu H.X., Adkins J. A., Wishnok J. S., and Tannenbaum S. R. - Chem. Res. Toxicol. 2: 94 (1989)
5. Friesen M. D., Garren L., Prevost V., and Shuker D. E. G. - Chem. Res. Toxicol. 4: 102 (1991)
6. Bonfanti M., Magagnotti C., Galli A., Bagnati R., Moret M., Gariboldi P., Fanelli R., and Airoldi L. - Cancer Res. 50: 6870 (1990)
7. Airoldi L., Galli A., Magagnotti C., Bagnati R., Lolli M., and Fanelli R. - Cancer Res. 52: 6699 (1992)
8. Loveless A. - Nature 223: 206 (1969)
9. Singer B. - J. Nat. Cancer Inst. 62: 1329 (1979)
10. Saffhill R., Margison G. P., and O'Connor P. J. - Biochim. Biophys. Acta 823: 111 (1985)
11. Stadler R. H., Staempfli A. A., Fay L. B., Turesky R. J., and Welti D. H. - Chem. Res. Toxicol. 7: 784 (1994)
12. Scheller N., Sangaiah R., Ranasinghe A., Amarnath V., Gold A., and Swenberg J.A. - Chem. Res. Toxicol. 8: 333 (1995)
13. Plentl A. A. and Schoenheimer R. - J. Biol. Chem. 153: 203 (1944)
14. Lazarus R. A., Sulewski M. A., and Benkovic S. J. - J. Labelled Compd. Radiopharm. 19: 1189 (1982)
15. Massefski Jr. W. and Redfield A. - J. Am. Chem. Soc. 112: 5350 (1990)
16. Tomsons U., Avots A., and Kolesnikova I. A. - Khim. Farm. Zh. 19: 206 (1985)
17. Beaman A. G., Gerster J. F., and Robins R. K. - J. Org. Chem. 27: 986 (1962)
18. Balsiger R. W. and Montgomery J. A. - J. Org. Chem. 25: 1573 (1960)
19. Beynon J. H., Hopkinson J. A., and Williams A. E. - Org. Mass Spectrom. 1: 169 (1968).
20. Airoldi L., Magagnotti C., Chiappetta L., Bonfanti M., Pastorelli R. and Fanelli R. -Carcinogenesis, 16: 2247 (1995).