An admonition when measuring the lipophilicity of radiotracers using counting techniques

Applied Radiation and Isotopes

Volumn 54, Issue 2, 2001, Pages 203-208

  Wilson, Alan A ^a   Jin, Li ^a   Garcia, Armando ^a   DaSilva, Jean N ^a   Houle, Sylvain ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Lipophilicity; Log P; QSAR; Radiotracers

Indexed keywords

IMPURITIES; RADIOACTIVITY;

LIPOPHILICITY; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS (QSAR);

RADIOACTIVE TRACERS;

1 [2,3 DIHYDRO 2 OXO 1 PIVALOYLMETHYL 5 (2 PYRIDYL) 1H 1,4 BENZODIAZEPIN 3 YL] 3 [3 (METHYLAMINO)PHENYL]UREA; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; FLUMAZENIL; FLUORODEOXYGLUCOSE F 18; ISOREMOXIPRIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RACLOPRIDE; RADIOACTIVE MATERIAL; ROLIPRAM; RTI 32; SETOPERONE; SKF 82957; TRACER; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG IMPURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIPOPHILICITY; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

1-OCTANOL; ANIMALS; CHEMISTRY, PHYSICAL; DRUG CONTAMINATION; HUMANS; LIPIDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOISOTOPES; SCINTILLATION COUNTING; SOLVENTS; WATER;

EID: 0035255404     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(00)00269-4     Document Type: Article

References (5)

1. The use of in vitro models to predict the distribution of receptor binding radiotracers in vivo
2. (3R)-n-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist