Telomerase regulation: Not just flipping the switch

Current Opinion in Genetics and Development

Volumn 12, Issue 1, 2002, Pages 80-85

  Aisner, Dara L ^a   Wright, Woodring E ^a   Shay, Jerry W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOLOENZYME; TELOMERASE;

ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REVIEW; TELOMERE; TRANSCRIPTION REGULATION;

EID: 0036467499     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(01)00268-4     Document Type: Review

References (56)

1. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
2. Structure and function of telomeres
3. Telomeres shorten during aging of human fibroblasts
4. Specific association of human telomerase activity with immortal cells and cancer
5. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
6. Reverse transcriptase motifs in the catalytic subunit of telomerase
7. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
8. Telomerase activity in human germline and embryonic tissues
9. Telomerase activity in hematopoietic cells is associated with self-renewal potential
10. Creation of human tumour cells with defined genetic elements
11. Extension of life-span by introduction of telomerase into normal human cells
12. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
13. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
14. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
15. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
16. The hTERTα splice variant is a dominant negative inhibitor of telomerase activity
17. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
18. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development
19. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus
20. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
21. Possible regulation of telomerase activity by transcription and alternative splicing of telomerase reverse transcriptase in human melanoma
22. Positive and negative regulation of telomerase access to the telomere
23. Assembly and regulation of telomerase
24. Identification of two RNA-binding proteins associated with human telomerase RNA
25. The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo
26. Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase
27. A telomerase component is defective in the human disease dyskeratosis congenita
28. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end
29. Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p
30. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
31. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
32. Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro
33. hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro
34. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation
35. Functional requirement of p23 and Hsp90 in telomerase complexes
36. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase
37. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues
38. Involvement of 14-3-3 proteins in nuclear localization of telomerase
39. Inactivation of 14-3-3 sigma influences telomere behavior and ionizing radiation-induced chromosomal instability
40. Human telomerase contains two cooperating telomerase RNA molecules
41. Functional multimerization of the human telomerase reverse transcriptase
42. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue
43. Differential regulation of telomerase activity and TERT expression during brain development in mice
44. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells
45. Telomerase is controlled by protein kinase Cα in human breast cancer cells
46. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
47. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
48. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation
49. Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
50. The chromosome ends of Saccharomyces cerevisiae
51. Telomere position effect in human cells
52. Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization
53. Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p
54. Transient expression of human telomerase extends the life span of normal human fibroblasts
55. Differences in telomere length between homologous chromosomes in humans
56. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase