Structure-activity relationships of α-conotoxins targeting neuronal nicotinic acetylcholine receptors

European Journal of Biochemistry

Volumn 271, Issue 12, 2004, Pages 2320-2326

  Millard, Emma L ^a   Daly, Norelle L ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

NMR; Peptide; X ray crystallography

Indexed keywords

ALPHA CONOTOXIN; ALPHA CONOTOXIN AUIB; ALPHA CONOTOXIN IMI; ALPHA CONOTOXIN IMII; ARGINYLASPARTYLPROLYLCYSTEINYLCYSTEINYLSERYLASPARAGINYLPROLYLVALYLCYSTEINYL THREONYLVALYLHISTIDYLASPARAGINYLPROLYLGLUTAMINYLISOLEUCYLCYSTEINE; CONOTOXIN; GLYCYLCYSTEINYLCYSTEINYLSERYLASPARAGINYLPROLYLVALYLCYSTEINYLHISTIDYLLEUCYLG LUTAMYLHISTIDYLSERYLASPARAGINYLLEUCYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLASPARTYLPROLYLARGINYLCYSTEINYLASPARAGINYLMETHI ONYLASPARAGINYLASPARAGINYLPROLYLASPARTYLTYROSYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLHISTIDYLPROLYLALANYLCYSTEINYLALANYLGLYCYLASPAR AGINYLASPARAGINYLGLUTAMINYLHISTIDYLISOLEUCYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLLEUCYLPROLYLPROLYLCYSTEINYLALANYLALANYLASPARAG INYLASPARAGINYLPROLYLASPARTYLTYROSYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLLEUCYLPROLYLPROLYLCYSTEINYLALANYLLEUCYLSERYLAS PARAGINYLPROLYLASPARTYLTYROSYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLTYROSYLPROLYLPROLYLCYSTEINYLPHENYLALANYLALANYL THREONYLASPARAGINYLSERYLASPARTYLTYROSYLCYSTEINE; GLYCYLCYSTEINYLCYSTEINYLSERYLTYROSYLPROLYLPROLYLCYSTEINYLPHENYLALANYLALANYL THREONYLASPARAGINYLSERYLGLYCYLTYROSYLCYSTEINE; GLYCYLGLYCYLCYSTEINYLCYSTEINYLSERYLHISTIDYLPROLYLALANYLCYSTEINYLALANYLALANY LASPARAGINYLASPARAGINYLGLUTAMINYLASPARTYLTYROSYLCYSTEINE; ISOLEUCYLARGINYLASPARTYL GAMMA CYSTEINYLCYSTEINYLSERYLASPARAGINYLPROLYLALANYLCYSTEINYLARGINYLVALYLASPARAGINYLAS PARAGINYLORNITHYLHISTIDYLVALYLCYSTEINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; SNAIL VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; DISULFIDE BOND; DRUG RECEPTOR BINDING; DRUG TARGETING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN TARGETING; RECEPTOR INTRINSIC ACTIVITY; SHORT SURVEY; STRUCTURE ACTIVITY RELATION; TOXIN ANALYSIS; TOXIN STRUCTURE; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; DISULFIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

GASTROPODA; INVERTEBRATA;

EID: 3042566993     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04148.x     Document Type: Short Survey

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