Solution structure of α-conotoxin ImI determined by two-dimensional NMR spectroscopy

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1431, Issue 2, 1999, Pages 384-394

  Gouda, Hiroaki ^a   Hirono, Shuichi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Acetylcholine receptor; Conus imperialis; Neurotoxin; Solution structure; Two dimensional nuclear magnetic resonance

Indexed keywords

ALPHA CONOTOXIN IMI; CONOTOXIN; NEUROTOXIN; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

CONOTOXINS; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLLUSK VENOMS; OLIGOPEPTIDES; RECEPTORS, NICOTINIC; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0032921719     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00065-5     Document Type: Article

References (31)

1. Olivera B.M., McIntosh J.M., Cruz L.J., Luque F.A., Gray W.R. Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry. 23:1984;5087-5090.
2. Olivera B.M., Gray W.R., Zeikus R., McIntosh J.M., Varga J., Rivier J., de Santos V., Cruz L.J. Peptide neurotoxins from fish-hunting cone snails. Science. 230:1985;1338-1343.
3. Gray W.R., Olivera B.M., Cruz L.J. Peptide toxins from venomous Conus snails. Annu. Rev. Biochem. 57:1988;665-700.
4. Shon K.-J., Grilley M.M., Marsh M., Yoshikami D., Hall A.R., Kurz B., Gray W.R., Imperial J.S., Hillyard D.R., Olivera B.M. Purification, characterization, synthesis, and cloning of the lockjaw peptide from Conus purpurascens venom. Biochemistry. 34:1995;4913-4918.
5. Terlau H., Shon K.-J., Grilley M., Stocker M., Stühmer W., Olivera B.M. Strategy for rapid immobilization of prey by a fish-hunting marine snail. Nature. 381:1996;148-151.
6. Gray W.R., Luque A., Olivera B.M., Barrett J., Cruz L.J. Peptide toxins from Conus geographus venom. J. Biol. Chem. 256:1981;4734-4740.
7. McIntosh M., Cruz L.J., Hunkapiller M.W., Gray W.R., Olivera B.M. Isolation and structure of a peptide toxin from the marine snail Conus magus. Arch. Biochem. Biophys. 218:1982;329-334.
8. Fainzilber M., Hasson A., Oren R., Burlingame A.L., Gordon D., Spira M.E., Zlotkin E. New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry. 33:1994;9523-9529.
9. Cartier G.E., Yoshikami D., Gray W.R., Luo S., Olivera B.M., McIntosh J.M. A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 271:1996;7522-7528.
10. Martinez J.S., Olivera B.M., Gray W.R., Craig A.G., Groebe D.R., Abramson S.N., McIntosh J.M. α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 34:1995;14519-14526.
11. McIntosh J.M., Yoshikami D., Mahe E., Nielsen D.B., River J.E., Gray W.R., Olivera B.M. A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J. Biol. Chem. 269:1994;16733-16739.
12. Guddat L.W., Martin J.A., Shan L., Edmundson A.B., Gray W.R. Three-dimensional structure of the α-conotoxin GI at 1.2 Å resolution. Biochemistry. 35:1996;11329-11335.
13. Hu S.-H., Gehrmann J., Guddat L.W., Alewood P.F., Craik D.J., Martin J.L. The 1.1 Å crystal structure of the neuronal acetylcholine receptor antagonist, α-conotoxin PnIA from Conus pennaceus. Structure. 4:1996;417-423.
14. Hu S.-H., Gehrmann J., Alewood P.F., Craik D.J., Martin J.L. Crystal structure at 1.1 Å resolution of α-conotoxin PnIB: comparison with α-conotoxins PnIA and GI. Biochemistry. 36:1997;11323-11330.
15. 1H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water. Biochim. Biophys. Acta. 1343:1997;327-334.
16. Shon K.-J., Koerber S.C., Rivier J.E., Olivera B.M., McIntosh J.M. Three-dimensional solution structure of α-conotoxin MII, an α3β2 neuronal nicotinic acetylcholine receptor-targeted ligand. Biochemistry. 36:1997;15693-15700.
17. 1H NMR spectra of proteins via double quantum filtering. Biochem. Biophys. Res. Commun. 117:1983;479-485.
18. Bax A., Davis D.G. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy. J. Magn. Reson. 65:1985;355-360.
19. Macura S., Huang Y., Suter D., Ernst R.R. Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins. J. Magn. Reson. 43:1981;259-281.
20. Bax A., Davis D.G. Practical aspects of two-dimensional transverse NOE spectroscopy. J. Magn. Reson. 63:1985;207-213.
21. Griesinger C., Sørensen O.W., Ernst R.R., Practical Aspects of the E. COSY technique. Measurement of scalar spin-spin coupling constants in peptides. J. Magn. Reson. 75:1987;474-492.
22. States D.J., Haberkorn R.A., Ruben D.J. A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants. J. Magn. Reson. 48:1982;286-292.
23. Cheetham J.C., Smith D.M., Aoki K.H., Stevenson J.L., Hoeffel T.J., Syed R.S., Egrie J., Harvey T.S. NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nat. Struct. Biol. 5:1998;861-866.
24. Wüthrich K., Billeter M., Brawn W. Pseudo-structures for the 20 common amino acids for use in studies of protein conformations by measurements of intramolecular proton-proton distance constraints with nuclear magnetic resonance. J. Mol. Biol. 169:1983;949-961.
25. A.T. Brünger, X-PLOR Manual, Version 3.1, Yale University, New Haven, CT, 1993.
26. Nilges M., Clore G.M., Gronenborn A.M. Determination of three-dimensional structures of proteins from interproton distance data by hybrid distance geometry-dynamical simulated annealing calculations. FEBS Lett. 229:1988;317-324.
27. Nilges M., Clore G.M., Gronenborn A.M. Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. FEBS Lett. 239:1988;129-136.
28. M. Nilges, J. Kuszewski, A.T. Brünger, in: J.C. Hoch (Ed.), Computational Aspects of the Study of Biological Macromolecules by NMR, Plenum Press, New York, 1991.
29. K. Wüthrich, NMR of Proteins and Nucleic Acids, John Wiley, New York, 1986.
30. Quiram P.A., Sine S.M. Structural elements in α-conotoxin ImI essential for binding to neuronal α7 receptors. J. Biol. Chem. 273:1998;11007-11011.
31. Sargent P.B. The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16:1993;403-443.