Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1266-1272

  Blanchfield, Joanne T ^a   Dutton, Julie L ^a   Hogg, Ronald C ^a   Gallagher, Oliver P ^a   Craik, David J ^a   Jones, Alun ^a   Adams, David J ^a   Lewis, Richard J ^a   Alewood, Paul F ^a   Toth, Istvan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINODODECANOIC ACID; ALPHA CONOTOXIN MII DERIVATIVE; AMINO ACID DERIVATIVE; ASPARAGINE; CONOTOXIN; LAURIC ACID DERIVATIVE; LIPOAMINO ACID; NICOTINIC RECEPTOR BLOCKING AGENT; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN CACO 2; CONJUGATE; CONTROLLED STUDY; CONUS MAGUS; CYTOPATHOGENIC EFFECT; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MONOLAYER CULTURE; OXIDATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SNAIL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CACO-2 CELLS; CONOTOXINS; GANGLIA, PARASYMPATHETIC; HEMOLYSIS; HUMANS; LAURIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR SEQUENCE DATA; NEURONS; NICOTINIC ANTAGONISTS; PATCH-CLAMP TECHNIQUES; PEPTIDES, CYCLIC; PERMEABILITY; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344406263     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020426j     Document Type: Article

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