A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 48849-48857

  Dutton, Julie L ^a   Bansal, Paramjit S ^a   Hogg, Ron C ^a   Adams, David J ^a   Alewood, Paul F ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CHEMICAL BONDS; ISOMERS; NEUROLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BIOLOGICAL ACTIVITY;

PROTEINS;

ALPHA CONOTOXIN AUIB; CONOTOXIN; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; DRUG SYNTHESIS; ISOMER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASYMPATHETIC GANGLION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; DISULFIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0037073683     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208842200     Document Type: Article

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