Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor

Journal of Physiology Paris

Volumn 92, Issue 2, 1998, Pages 101-105

  Sine, Steven M ^a   Bren, Nina ^a   Quiram, Polly A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Curare; Molecular dissection; Subunit interfaces; conotoxins

Indexed keywords

ALPHA BUNGAROTOXIN I 125; CHIMERIC PROTEIN; CHOLINERGIC RECEPTOR; CONOTOXIN; CURARE; CYSTEINE; DIMETHYLTUBOCURARINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; SEROTONIN RECEPTOR;

BINDING AFFINITY; BINDING SITE; CHOLINERGIC SYSTEM; COMPLEX FORMATION; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; LIGAND BINDING; POINT MUTATION; PROTEIN LOCALIZATION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR SENSITIVITY; STRUCTURE ACTIVITY RELATION;

EID: 0032464958     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(98)80145-9     Document Type: Conference Paper

References (6)

1. [1] Bren N., Sine S.M., Identification of residues in the adult nicotinic acetylcholine receptor that confer selectivity for curariform antagonists, J. Biol. Chem. 272 (1997) 30793-30798.
2. [2] Prince R.J., Sine S.M., Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of residues that determine agonist selectivity, J. Biol. Chem. 271 (1996) 25770-25777.
3. 7 receptors, J. Biol. Chem. 273 (1998) 11007-11011.
4. [4] Sine S.M., Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of residues that determine curare selectivity, Proc. Natl. Acad. Sci. USA 90 (1993) 9436-9440.
5. [5] Sine S.M., Kreienkamp H.-J., Bren N., Maeda R., Taylor P., Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity, Neuron 15 (1995) 205-211.
6. [6] Sine S.M., Identification of equivalent residues in the γ, δ, and ε subunits of the nicotinic receptor that contribute to α-btx binding, J. Biol. Chem. 272 (1997) 23521-23527.