The 1.1 Å Resolution crystal structure of [Tyr15]EpI, a novel α- Conotoxin from Conus episcopatus, solved by direct methods

Biochemistry

Volumn 37, Issue 33, 1998, Pages 11425-11433

  Hu, Shu Hong ^a   Loughnan, Marion ^a   Miller, Russ ^b,c   Weeks, Charles M ^c   Blessing, Robert H ^c   Alewood, Paul F ^a   Lewis, Richard J ^a   Martin, Jennifer L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b the State University of New York   (United States)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; CONOTOXIN; ION CHANNEL; ALPHA CONOTOXIN EPI; ALPHA-CONOTOXIN EPI; MOLLUSC VENOM; NEUROPEPTIDE; SOLVENT; TYROSINE;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG RECEPTOR BINDING; ENVENOMATION; LIGAND BINDING; NEUROMUSCULAR SYSTEM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; CRYSTALLIZATION; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

CONUS EPISCOPATUS; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; CONOTOXINS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLLUSK VENOMS; NEUROPEPTIDES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOLVENTS; TYROSINE;

EID: 0032543962     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9806549     Document Type: Article

References (47)

1. Olivera, B. M., Rivier, J., Clark, C., Ramilo, C. A., Corpuz, G. P., Abogadie, F. C., Mena, E. E., Woodward, S. R., Hillyard, D. R., and Cruz, L. J. (1990) Science 249, 257-263.
2. Kohn, A. J., and Nybakken, J. W. (1975) Mar. Biol. (Berlin) 29, 211-234.
3. Olivera, B. M., McIntosh, J. M., Cruz, L. J., Luque, F. A., and Gray, W. R. (1984) Biochemistry 23, 5087-5090.
4. Olivera, B. M., Gray, W. R., Zeiku, R., McIntoch, J. M., Varga, J., River, J., de Santos, V., and Cruz, L. J. (1985) Science 230, 1338-1343.
5. Fainzilber, M., Nakamura, T., Gathon, A., Lodder, J. C., Kits, K. S., Burlingame, A. L., and Zlotkin, E. (1995) Biochemistry 34, 8649-8656.
6. Shon, K.-J., Grilley, M., Marsh, M., Yoshikami, D., Hall, A. R., Kurz, B., Gray, W. R., Imperial, J. S., Hillyard, D. R., and Olivera, B. M. (1995) Biochemistry 34, 4913-4918.
7. Terlau, H., Shon, K.-J., Grilley, M., Stocker, M., Stühmer, W., and Olivera, B. M. (1996) Nature 381, 148-151.
8. Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995) Nature 376, 514-516.
9. Holladay, M. W., Lebold, S. S., and Lin, N.-H. (1995) Drug Dev. Res. 35, 191-213.
10. Galzi, J.-L., Revah, F., Besis, A., and Changeux, J.-P. (1991) Annu. Rev. Pharmacol. 31, 37-72.
11. Barchan, D., Ovadia, M., Kochva, E., and Fuchs, S. (1995) Biochemistry 34, 9172-9176.
12. Gray, W. R., Luque, A., Olivera, B. M., Barrett, J., and Cruz, L. J. (1981) J. Biol. Chem. 256, 4734-4740.
13. McIntosh, J. M., Ghomashchi, F., Gelb, M. H., Dooley, D. J., Stoehr, S. J., Giordani, A. B., Naisbett, S. R., and Olivera, B. M. (1995) J. Biol. Chem. 270, 3518-3526.
14. Zafaralla, G. C., Ramilo, C. A., Gray, W. R., Karlstron, R., Olivera, B. M., and Cruz, L. J. (1988) Biochemistry 27, 7102-7105.
15. Myers, R. A., Zafaralla, G. C., Gray, W. R., Abbot, J., Cruz, L. J., and Olivera, B. M. (1991) Biochemistry 30, 9370-9377.
16. Ramilo, C. A., Zafaralla, G. C., Nadasdi, L., Hammerland, L. G., Yoshikami, D., Gray, W. R., Kristipati, R., Ramachandran, J., Miljanich, G., Olivera, B. M., and Cruz, L. J. (1992) Biochemistry 31, 9919-9926.
17. Martinez, J. S., Olivera, B. M., Gray, W. R., Craig, A. G., Groebe, D. R., Abramson, S. N., and McIntosh, J. M. (1995) Biochemistry 34, 14519-14526.
18. Fainzilber, M., Hasson, A., Oren, R., Burlingame, A. L., Gordon, D., Spire, M. E., and Zlotkin, E. (1994) Biochemistry 33, 9523-9529.
19. McIntosh, J. M., Yoshikami, D., Mahe, E., Nielsen, D. B., Rivier, J. E., Gray, W. R., and Olivera, B. M. (1994) J. Biol. Chem. 269, 16733-16739.
20. Cartier, G. E., Yoshikami, D., Gray, W. R., Luo, S., Olivera, B. M., and McIntosh, J. M. (1996) J. Biol. Chem. 271, 7522-7528.
21. Loughnan, M., Bond, T., Atkins, A., Jones, A., Gehrmann, J., Cuevas, J., Adams, D. J., Broxton, N., Livett, B., Down, J., Alewood, P. F., and Lewis, R. J. (1998) J. Biol. Chem. 273, 15667-15674.
22. Hopkins, C., Grilley, M., Miller, C., Shon, K.-J., Cruz, L. J., Gray, W. R., Dykert, J., River, J., Yoshikami, D., and Olivera, B. M. (1995) J. Biol. Chem. 270, 22361-22367.
23. Jacobsen, R., Yoshikami, D., Ellison, M., Martinez, J., Gray, W. R., Cartier, G. E., Shon, K.-J., Groebe, D. R., Abramson, S. N., Olivera, B. M., and McIntosh, J. M. (1997) J. Biol. Chem. 272, 22531-22537.
24. Guddat, L. W., Martin, J., Shan, L., Edmundson, A. B., and Gray, W. R. (1996) Biochemistry 35, 11329-11335.
25. Hu, S.-H., Gehrmann, J., Guddat, L. W., Alewood, P. F., Craik, D. J., and Martin, J. L. (1996) Structure 4, 417-423.
26. Hu, S.-H., Gehrmann, J., Alewood, P. F., Craik, D. J., and Martin, J. L. (1997) Biochemistry 36, 11323-11330.
27. Matthew, B. W. (1968) J. Mol. Biol. 33, 491-497.
28. Minor, W. (1993) XDIPLAYF Program, Purdue University, West Lafayette, IN.
29. Otwinowski, Z. (1993) in Proceeding of the CCP4 Study Weekend: Data Collection and Processing (Sawyer, L., Issacs, N., and Bailey, D., Eds.) pp 55-62. SERC Daresbury Laboratory, Warrington, U.K.
30. Miller, R., Gallo, S. M., Khalak, H. G., and Weeks, C. M. (1994) J. Appl. Crystallogr. 27, 613-621.
31. Weeks, C. M., and Miller, R. (1997) Direct methods for solving macromolecular structures, Kluwer, Dordrecht, The Netherlands.
32. Blessing, R. H., Guo, D. Y., and Langs, D. A. (1996) Acta Crystallogr. D52, 257-266.
33. Brünger, A. T. (1992) X-PLOR (version 3.1) Manual, Yale University Press, New Haven, CT.
34. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
35. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A47, 392-400.
36. Sheldrick, G. M. (1997) SHELXL97, A program for crystal structure refinement, University of Göttingen, Göttingen, Germany.
37. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
38. Nicholls, A., Bharadwaj, R., and Honing, B. (1993) Biophys. J. 64, 116.
39. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
40. Luzzati, V. (1952) Acta Crystallogr. 5, 802-810.
41. Richardson, J. S. (1981) Adv. Protein Chem. 34, 1-109.
42. Srinivasan, N., Sowdhamini, R., Ramakrishnan, C., and Balaram, P. (1990) Int. J. Pept. Protein Res. 36, 147-155.
43. Janin, J., Miller, S., and Chothia, C. (1988) J. Mol. Biol. 204, 155-164.
44. Shon, K. J., Koerber, S. C., Rivier, J. E., Olivera, B. M., and McIntosh, J. M. (1997) Biochemistry 36, 15693-15700.
45. Ealick, S. E. (1997) Structure 5, 469-472.
46. Han, K.-H., Hwang, K.-J., Kim, S.-M., Kim, S.-K., Gray, W. R., Olivera, B. M., River, J., and Shon, K.-J. (1997) Biochemistry 36, 1669-1677.
47. Brünger, A. T. (1992) Nature 355, 472-475.