Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides

Neuropharmacology

Volumn 41, Issue 7, 2001, Pages 801-810

  Klein, Rebecca C ^a   Warder, Scott E ^a   Galdzicki, Zygmunt ^b   Castellino, Francis J ^a   Prorok, Mary ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Carboxyglutamic acid; Antagonism; Conantokins; Electrophysiology; Kinetics; N methyl D aspartate receptor

Indexed keywords

4 CARBOXYGLUTAMIC ACID; CONANTOKIN DERIVATIVE; CONANTOKIN R; CONANTOKIN T; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PEPTIDE DERIVATIVE; SARCOSINE; SPERMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; EMBRYO; ENZYME INHIBITION; ENZYME KINETICS; FETUS; HIPPOCAMPUS; MOUSE; NERVE CELL CULTURE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN VARIANT; RAT; RECEPTOR BLOCKING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; CONOTOXINS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FETUS; HIPPOCAMPUS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MOLLUSK VENOMS; NEURONS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; RECEPTORS, N-METHYL-D-ASPARTATE; SPERMINE;

EID: 0034783460     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00119-8     Document Type: Article

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